|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of Matricaria chamomilla Hydroalcoholic Extract on Cisplatin-induced Neuropathy in Mice显示文摘AIM: Cisplatin-based chemotherapy is a mainstay for the treatment of solid tumors, especially colorectal, ovarian, testicular, bladder, and lung cancer. Studies have shown that cisplatin could have painful effects on human and animal models. Matri-caria chamomilla (MC) has analgesic and anti-inflammatory effects. The aim of this study was to investigate the effects of MC hydro-alcoholic extract on cisplatin-induced peripheral neuropathy and to compare with morphine in mice. METHODS: Experiments were performed on 60 NMRI male mice weighed 25 g to 30 g which have been divided into 6 groups. The first group received normal saline; the second group received MC hydroalcoholic extract; the third group received cisplatin; the fourth group received MC hydroalcoholic extract and cisplatin, 96 hours before formalin test; the fifth group received morphine and the sixth group received cisplatin and mor-phine. The time of injected hind paw biting and licking time were measured in 5-minute interval for an hour. RESULTS: Results showed that formalin induced significant (P < 0.05) pain response (the first phase: 0-5 min and the second phase: 15-40 min after injection). Administration of MC extract before formalin injection showed significant (P < 0.05) decrease of pain responses in the first and second phase. Administration of cisplatin produced significant (P < 0.05) increase in pain response in both phases of formalin test. Injection of MC extract and cisplatin together have shown that MC is able to decrease the second phase of cisplatin-induced pain sig-nificantly (P < 0.05). Morphine decreased cisplatin-induced pain in the first and second phase of formalin test significantly ( P < 0.05). In comparison morphine has analgesic effects in the first phase and MC extract has anti inflammatory effects in the second phase of formalin test significantly (P < 0.05). CONCLUSION: MC and cisplatin have analgesic and painful neuropathic respective effects, and MC hydroalcoholic extract is able to decrease cisplatin-induced pain and inflammation better than morphine. | A. Namvaran Abbas Abad M.H. Kayate Nouri A. Gharjanie F. Tavakoli | 2011 | 中国天然药物2011，9，2： | 3 |
| 2 | Effect of Salvia officinalis Hydroalcoholic Extract on Vincristine-induced Neuropathy in Mice显示文摘AIM:Vincristine is one of the most commonly used chemotherapeutic drugs to treat a variety of malignant diseases,including leukemia and lymphoma.Studies have shown that vincristine cause painful effects,whereas Salvia officinalis(SO) showed analgesic and anti-inflammatory effects.The aim of this study is to investigate the effects of the SO hydro-alcoholic extract on vincristine-induced peripheral neuropathy in mice in comparison with morphine.METHODS:Experiments were performed on 60 NMRI male mice weighing 25-30 g divided into six groups.The individual groups received normal saline,SO hydro-alcoholic extract,vincristine,SO hydro-alcoholic extract and vincristine(12 days before formalin test),morphine,and vincristine and morphine,respectively.The injected hind paw biting and licking was measured in a 5-minute interval for one hour.RESULTS:The results showed that formalin induce significant(P < 0.05) pain responses(the first phase:0-5 min and the second phase:15-40 min after injection).Administration of SO extract before formalin test showed significant(P < 0.05) decrease of pain response in the second phase.Administration of vincristine caused significant(P < 0.05) increase in the second phase of pain response.Injections of SO extract and vincristine showed that SO significantly(P < 0.05) decrease the second phase of vincristine-induced pain.Morphine decreased vincristine-induced pain in the first and second phase of formalin test significantly(P < 0.05).In comparison,morphine showed analgesic effects in the first phase and SO extract showed significant(P < 0.05) anti-inflammatory effects in the second phase of formalin test.CONCLUSION:Both SO and vincristine showed analgesic and painful neuropathic effects,suggesting that SO extract could be useful in the treatment of vincristine-induced peripheral neuropathic pain. | Ali Namvaran Abbas Abad Mir Hadi Khayate Nouri Farzaneh Tavakkoli | 2011 | 中国天然药物2011，9，5： | 3 |
| 3 | Polymorph-ism of adiponectin (45T/G) and adiponectin receptor-2 (795G/A) in an Iranian population:relation with insulin' resistance and response to treatment with pioglitaz0ne in patients with type 2 diabetes mellitus显示文摘 | Namvaran F Rahimi-Moghaddam P Azarpira N | 2012 | Molecular Biology Reports2012，，5： | 1 |
| 4 | Polymorph-ism of adiponectin (45T/G) and adiponectin receptor -2 ( 795G/A) in an Iranian population: relation with insulin resistance and re-sponse to treatment with pioglitazone in patients with type 2 diabetesmellitus显示文摘 | Namvaran F Rahimi-Moghaddam P Azarpira N | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 5 | Polymorphism of peroxisome proliferator-activated re-ceptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglita- zone in type 2 diabetes 显示文摘 | Namvaran F Azarpira N Rahimi-Moghaddam P Dabbaghmane- sh MH | 2011 | Eur J Pharmacol2011，671，13： | 1 |
| 6 | Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: Relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes显示文摘 | Fatemeh Namvaran Negar Azarpira Parvaneh Rahimi-Moghaddam Mohammad Hossein Dabbaghmanesh | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 7 | Road safety data collection systems in Iran: A comparison based on relevant organizations显示文摘Purpose:Various organizations and institutions are involved in road traffic injury(RTI)and crash registration such as police,forensic medicine organization,hospitals and emergency medical services.But there is a substantial uncertainty in interpreting the data,duplicated data collection and missing data in relation to RTI in most systems.This study aims to identify data sources for RTI surveillance in Iran and to explore traffic safety data source domains,data elements and detailed information by each data source.Methods:This is a qualitative study which was conducted in 2017 in Iran.Data were collected employing semi-structured interviews with informants in road safety organizations in relation to traffic safety including Police,Ministry of Health and Medical Education as well as Forensic Medicine Organization and other authorities-in-charge.For completing the preliminary extraction information,the minimum data set was used and compared in each system.Results:Eight different organizations relevant to road traffic safety were identified.The main domain of data provided by each one consists of Emergency Medical System form,Police KAM114 form,Ministry of Transport and Road Administration,Red Crescent Organization/Disaster Management Information System,Ministry of Health and Medical Education,Forensic Medicine Organization,Insurance Company and Ministry of Justice.Each system has its own database,based upon its scope and mainly at crash and postcrash status and little on pre-crash circumstance.Conclusion:All current registry systems are not surveillance systems for RTI prevention.Huge data have been collected in various registry systems in Iran,but most of the collected variables are duplicated in each system.On the other hand,some variables like alcohol and substance abuse,child seat belt,helmet use in relation to RTI prevention are missed in all systems.Accordingly,it is a critical need to integrate and establish a comprehensive surveillance system,with focus on the goal of each system and collection of minimum data in each organization,which currently is underway. | Homayoun Sadeghi-Bazargani Sakineh Sharifian Davoud Khorasani-Zavareh Raana Zakeri Mehdi Sadigh Mina Golestani Mousa Amiri Reza Masoudifar Farzad Rahmani Nasser Mikaeeli Javad Namvaran Khalil Pour-Ebrahim Mahdi Rezaei Babak Arabzadeh Bahram Samadirad Aliashraf Seyffarshad Fariba Mirza-Mohammadi-Teimorloue Shahin Kazemnezhad Soudabe Marin Saeede Sheikhi Reza Mohammadi | 2020 | Chinese Journal of Traumatology2020，23，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员