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| 1 | The role of Interleukin - 1 in acuteneurodegeneration and stroke: Pathophysiological and therapeutic implications 显示文摘 | Nancy R Stuart A Sylvie T | 1997 | J Clin Invest1997，100，1： | 1 |
| 2 | Changes in nutrient structure of river-dominated coastal waters:Stoichiometric nutrient balance and its consequences显示文摘 | DUBRAVKO N R JUSTIC R E NANCY T | 1995 | Esturarine Coastal and Shelf Science1995，40，3： | 1 |
| 3 | The importance of glycemic control in wound healing显示文摘 | Nancy C Fapwca R T | | 0，，13： | 1 |
| 4 | Analysis of imprinted messenger RNA expression during bovine preirnplantation development显示文摘 | Nancy T R Katrina J W Melissa A C | 2004 | Bio Reprod2004，70，： | 1 |
| 5 | Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential 显示文摘 | Rieko T Almudena R Nancy K | 2007 | Biooganic &Medicinal Chemistry2007，15，： | 1 |
| 6 | Management of child and adolescent obe-sity:attitudes,barriers,skills,and training needs among health careprofessionals显示文摘 | Mary T Dianne R Nancy E | 2002 | Pediatrics2002，110，： | 1 |
| 7 | Changes in nutrient structure of river-dominated coastal waters: Stoichiometric nutrient balance and its consequences显示文摘 | DUBRAVKO N R JUSTIC R E NANCY T | 1995 | Esturarine Coastal and Shelf Science1995，40，3： | 1 |
| 8 | Heart disease and stroke statistics显示文摘 | Thomas T Nancy H Wayne R | 2006 | Circulation2006，113，6： | 1 |
| 9 | Insurer policies create barriers to health care access and consumer choice显示文摘 | Hansen T T Ann R Nancy R | 2006 | Nurs Econo2006，24，4： | 1 |
| 10 | An introduction to input/output automata显示文摘 | Mark R T | 1989 | CWI-Quarterly1989，，： | 1 |
| 11 | Changes in nutrient structure of river-dominated coastal waters: Stuichiometric nutrient balance and its consequences 显示文摘 | DU BRAVKO N R JUSTIC R E NANCY T | 1995 | Esturarine Coastal and Shelf Science1995，40，3： | 1 |
| 12 | Management of child and adolescent obesity: attitudes, barriers, skills, and training needs among health care professionals 显示文摘 | Mary T Dianne R Nancy E | 2002 | Pediatrics2002，110，： | 1 |
| 13 | A distinct lineage of influenza A virus from bats 显示文摘 | Suxiang Tong Yah Li Pierre Rivailler Christina Con- rardy Danilo A Alvarez Castillo Li-Mei Chen Sergio Recuenco James A Ellison Charles T Davis Ian A York Amy S Turmelle David Moran Shannon Rog- ers Mang Shi Ying Tao Michael R Weil Kevin Tang Lori A Rowe Scott Sammons Xiyan Xu Mi- chael Frace Kim A Lindblade Nancy J Cox Larry J Anderson Charles E Rupprecht Ruben O Donis | 2012 | PANS U S A2012，109，11： | 1 |
| 14 | Avian influenza (HSN1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals显示文摘 | Taronna R Maines Xui Hua Lu Steven M Erb Lind- say Edwards Jeannette Guarner Patrieia W Greer Doan C Nguyen Kristy J Szretter Li-Mei Chen Prance Thawatsupha Malinee Chittaganpitch Sunthareeya Waicharoen Diep T Nguyen Tung Nguyen Hanh H T Nguyen Jae-Hong Kim Long T Hoang Chun Kang Lien S Phuong Wilina Lim Sherif Zaki Ruben O Do- nis Nancy J Cox Jacqueline M Katz Terrence M Tumpey | 2005 | J Virol2005，79，11： | 1 |
| 15 | Sequence Variations within PrfA DNA Binding Sites and Effects on Listeria monocytogenes Virulence Gene Expression显示文摘 | James R W Chetna T Nancy E F | 2000 | Journal of Bacteriology2000，182，3： | 1 |
| 16 | The potential induced in anisotropic tissue by the ultrasonically-induced lorentz force显示文摘 | Nancy T Bradley J R | 2008 | Medical and Biological Engineeringand Computing2008，46，2： | 1 |
| 17 | Utility of the low-accelerating-dose regimen in 182 liver recipients with recurrent hepatitis C virus显示文摘AIM: To describe our experience using a low-acceleratingdose regimen(LADR) with pegylated interferon alpha-2a and ribavirin in treatment of hepatitis C virus(HCV) recurrence. METHODS: From 2003, a protocolized LADR strategy was employed to treat liver transplant(LT) recipients with recurrent HCV at our institution. Medical records of 182 adult patients with recurrent HCV treated with LADR between 1/2003 and 1/2011 were reviewed. Histopathology from all post-LT liver biopsies were reviewed in a blinded fashion. Paired recipient and donor IL28 B status were assessed. A novel technique was employed to ascertain recipient and donor IL28B(rs12979860) Gt data using DNA extracted from archival FFPE tissue from explanted native livers and donor gallbladders respectively. The primary endpoint was SVR; secondary endpoints examined include(1) patient and graft survival;(2) effect of anti-viral therapy on liver histology(fibrosis and inflammation);(3) incidence of on-treatment development of ACR, CDR, or PCH;(4) association of recipient and donor IL28 B genotype with SVR; and(5) incidence of antiviral therapy-associated adverse events(anemia, leukopenia, thrombocytopenia, depression) and hepatic decompensation.RESULTS: The overall SVR rate was 38%(29% Gt1, 67% Gt2, 86% Gt3 and 58% Gt4). HCV Gt(P < 0.0001), donor age(P = 0.003), cytomegalovirus mismatch(P = 0.001), baseline serum bilirubin(P = 0.002), and baseline viral load(P = 0.04) were independent predictors for SVR. SVR rates were significantly higher in the recipient-CC/donor-non CC pairs(P = 0.007). Neither baseline fibrosis nor change in fibrosis stage after anti-viral therapy were associated with SVR. Fibrosis progressed in 72% of patients despite SVR. Median graft survival was 91 mo. Five-year patient survival was superior in patients who achieved SVR(97% vs 82%, P = 0.001). Pre-treatment ALP ≥ 150 U/L(P = 0.01), total bilirubin ≥ 1.5 mg/d L(P = 0.001) and creatinine ≥ 2 mg/d L(P = 0.001) were independently associated with patient survival. Only 13% of patients achieving SVR died during the followup period. Treatment discontinuation and treatmentrelated mortality occurred in 35% and 2.2% of patients, respectively. EPO, G-CSF and blood transfusion were needed in 89%, 40% and 23% of patients, respectively. Overall hospitalization rate for treatment-related serious adverse events was 21%. Forty-six(25%) of the patients were deceased; among those who died, 25(54%) were due to liver-related complications, and 4 deaths(9%) occurred while receiving therapy(2 patients experienced hepatic decompensation and 2 sepsis). CONCLUSION: LADR strategy remains relevant in managing post-LT recurrent HCV where access to DAAs is limited. SVR is associated with improved survival, but fibrosis progression still occurs. | Kieron BL Lim Hamid R Sima M Isabel Fiel Viktoriya Khaitova John T Doucette Maria Chernyiak Jawad Ahmad Nancy Bach Charissa Chang Priya Grewal Leona Kim-Schluger Lawrence Liu Joseph Odin Ponni Perumalswami Sander S Florman Thomas D Schiano | 2015 | World Journal of Gastroenterology2015，21，20： | 0 |
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