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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | High-dose intravenous immunoglobulin for the treatment of MuSK antibody-positive seronegatire myasthenia gravis显示文摘 | Hirokatsu T Naoki K Yuko N | 2006 | Neurol Sci2006，247，： | 1 |
| 3 | Impact of decreased estimated glo- merular filtration rate on japanese acute stroke and its subtype显示文摘 | Junko C Naoki N Maki K | 2012 | Intern Med2012，51，13： | 1 |
| 4 | Determination of ochratoxin A in ready-to-drink coffee by im- munoaffinity cleanup and liquid chromatogra- phy-tandem mass spectrometry 显示文摘 | Shigekuni N Atsuo U Naoki M | 2009 | Journal of A- gricultural and Food Chemistry2009，57，1： | 1 |
| 5 | Effects of thymectomy on lateonset myasthenia gravis without thymoma显示文摘 | Naoki K Satoshi K Yuko N | 2007 | Clin Neuro and Neurosur2007，109，： | 1 |
| 6 | Enhanced production of L(+)lactic acid from corn starch in culture of Rhizopus oryzae using an air-lift bioreactor显示文摘 | Yin P Naoki N Kosakai Y | 1997 | J of Fermentation and Bioengineering1997，84，3： | 1 |
| 7 | Suger-mimicglycosidase in- hibitors: natural occurrence, biological activity and prospects for therapeutic application 显示文摘 | Naoki A Robert J N Russell J | 2000 | Tetrahedron Asymmetry2000，11，8： | 1 |
| 8 | Revision of the genus Girella (Gi- rellidae) from East Asia 显示文摘 | NAOKI Y TETSUJI N | 1999 | Ichthyol Res1999，47，2： | 1 |
| 9 | Quantitative detective of micrometastases in the lymph nodes of gastric cancer patients with real-time RT-PCR,A comparative study with immunohistochemistry显示文摘 | Keisuk K Hayan N Naoki H | 2003 | Int J Cancer2003，105，2： | 1 |
| 10 | Evolutionary trend in feeding habits of Girella显示文摘 | NAOKI Y TETSUJI N | 2003 | Ichthyol Res2003，50，： | 1 |
| 11 | Synthesis of sulfated oligosaccharide glycosides having high anti-HIV activity and the relationship between activity and chemical structure 显示文摘 | Kaname K Hideki N Naoki Y | 1999 | Carbohydr Res1999，315，34： | 1 |
| 12 | Central role of endogenous Toll-like receptor-2 activation in regulating inflammation,reactive oxygen species production,and subsequent neointimal formation after vascular injury显示文摘 | TETSURO S NAOKI N HIROKI T | 2006 | Biochem Biophys Res Commun2006，345，： | 1 |
| 13 | Case of bilateral chylothorax with systemic lupus eythematosus complicated by steroid-/immunosuppressant-resistant pleural effusion 显示文摘 | Narita Y Naoki K Hida N | 2008 | Nihon Kokyuki Gakkai Zasshi2008，46，： | 1 |
| 14 | Identification of genes coding enzymes for ascomycin tetra-hydropyranose ring formation显示文摘 | Takafumi U Fumihiro F Naoki N | | 0，，： | 1 |
| 15 | CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptasepolymerase chain reaction显示文摘 | Yoichi Y Naoki I Hisashi N | 2003 | Oncology Reports2003，10，6： | 1 |
| 16 | Transduction of KAll/CD82 cD- NA promotes hematogenous spread of human lung cancer cells in natural killer cell depleted SCID mice显示文摘 | Tsutomu S Naoki N Masaki H | 2001 | Cancer2001，94，： | 1 |
| 17 | Factors influencing the outcome of deep infection following total knee arthroplasty显示文摘 | Naoki N Tomoyuki M Kazunari I | 2015 | Knee2015，22，4： | 1 |
| 18 | Low and high frequency acupunctrue stimulations mental stress - induced sweating in humans via different mechanisms 显示文摘 | Kihiro O Junichi S Naoki N | 2005 | Autonomic Neurosci2005，118，12： | 1 |
| 19 | Selective reactions using allylic metals显示文摘 | YAMAMOTO Y NAOKI ASAO N | 1993 | Chem Rev1993，93，6： | 1 |
| 20 | Survivin as a predictor of cis-diamminedichloroplatinum sensitivity in gastric cancer patients显示文摘 | MASASHI N NAOKI T KOICHI A | | 0，，01： | 1 |
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