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| 1 | Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling显示文摘 | Albert W Cheng Nathaniel Jillette Phoebe Lee Dylan Plaskon Yasuhiro Fuj iwara Wenbo Wang Aziz Taghbalout Haoyi Wang | 2016 | Cell Research2016，26，2： | 19 |
| 2 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 3 | Foote; Eric Matson; Nicholas Rudd, Managing the Knowledge Manager 显示文摘 | Nathaniel W | 2001 | The Mckinsey Quarterly2001，3，： | 1 |
| 4 | Renewable-resource Thermoplastic Elastomers Based on Poly- lactide and Polymenthide显示文摘 | Carolyn L W Leslie E O Nathaniel A L | 2007 | Biomacromolecules2007，，8： | 1 |
| 5 | An Octahedral Template Based on a New Molecular Turn:Synthesis and Structure of a Model Complex and a Reactive,Diphenolic Ligand and Its Metal Complexes显示文摘 | Andrew L V Nathaniel W A Joseph A H | 1998 | Inorg Chem1998，37，： | 1 |
| 6 | Foote; Eric Matson; Nicholas Rudd, Managing the Knowledge Manager 显示文摘 | Nathaniel W | 2001 | The Mckinsey Quarterly2001，3，： | 1 |
| 7 | Measuring the self-stigma associated with seeking psychological help显示文摘 | Vogel D L Nathaniel G W Haake S | 2006 | Journal of Counse-ling Psychology2006，53，3： | 1 |
| 8 | Quantitation of Human Left Ventricular Mass and Volume by Two-dimensional Echocardiography: In Vitro Anatomic Validation显示文摘 | JOSEPH W HELAK NATHANIEL REICHEK | 1981 | Circulation1981，，6： | 1 |
| 9 | Foote; Eric Matson; Nicholas Rudd, Managing the Knowledge Manager 显示文摘 | Nathaniel W | 2001 | The Mckinsey Quarterly2001，3，： | 1 |
| 10 | Activation of NFKB is inhibited by curcurain and related enones 显示文摘 | WEBER W M HUNSAKER L A NATHANIEL R C | 2006 | Bioorg Med Chem2006，14，7： | 1 |
| 11 | Entrepreneurial orientation and market orientation as drivers of product innova- tion success: A study of exporters from a developing economy显示文摘 | Nathaniel B Cadogan J W | 2012 | International Small Business Journal2012，11，3： | 1 |
| 12 | Malignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurine显示文摘 | Burton I Korelitz Felice J Mirsky Mark R Fleisher Jonathan I Warman Nathaniel Wisch Gilbert W Gleim | 1999 | The American Journal of Gastroenterology1999，，11： | 1 |
| 13 | Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B显示文摘 | Young-Oh Kweon Zachary D Goodman Jules L Dienstag Eugene R Schiff Nathaniel A Brown Elmar Burkhardt Robert Schoonhoven David A Brenner Michael W Fried | 2001 | Journal of Hepatology2001，，： | 1 |
| 14 | Methods for estimating the optimal dividend barrier and the probability of ruin Insurance显示文摘 | GERBER H U SHIU E S W NATHANIEL S | 2008 | Mathematics and Economics2008，42，2： | 1 |
| 15 | Role of the Natriuretic peptide system in cardiorenal protection显示文摘 | Smay L Nathaniel W James SR | 2003 | Archives of Int Med2003，163，22： | 1 |
| 16 | Assessing mobility and Redistribution Patterns of Sand and Oil Agglomerates in the Surf zone显示文摘 | PSoupy Dalyander Joseph W Long Nathaniel G Plant | 2014 | Marine Pollution bulletin2014，80，1： | 1 |
| 17 | A new criterion of phase separation : the effect of diamine chain extenders on the properties of polyurethaneureas 显示文摘 | Can B H Robert S W Nathaniel S S | 1982 | Journal of Applied Polymer Science1982，27，6： | 1 |
| 18 | A critical review of the risks to water resources from unconventional shale gas development and hydraulic fracturing in the United States 显示文摘 | AVNER V JACKSON R B NATHANIEL W eta/ | 2014 | Environmental Science & Technology2014，48，15： | 1 |
| 19 | Entrepreneurial Orientation, Market Orientation, Network Ties, and Performance: Study of Entrepreneurialfirms in a Developing Economy 显示文摘 | Boso Nathaniel Vicky M Story John W Cadogan | 2013 | Journal of Business Venturing2013，28，： | 1 |
| 20 | The ABCs of eye color in Tribolium castaneum:orthologs of the Drosophila white,scarlet,and brown genes显示文摘 | NATHANIEL G SUE H BEEMAN R W | 2015 | Genetics2015，199，3： | 1 |
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