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| 1 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 2 | Clinical significance of alphafetoproteinmRNA in blood of patients with hepatocellular carcinoma显示文摘 | Cillo U Navaglia F Vitale A | 2004 | Clin Chim Acta2004，347，12： | 1 |
| 3 | Pro-and anti-inflammatory eytokines gene polymorphisms and Heli- cobacter pylori infection : interactions influence outcome 显示文摘 | CARLO-F ZAMBON DANIELA BASSO FILIPPO NAVAGLIA et al | 2005 | Cytokine2005，29，4： | 1 |
| 4 | Clinical evaluation of seven tumor markers in lung cancer diagnosis : can any combination improve the results 显示文摘 | Plebani M Basso D Navaglia F | 1995 | Br J Cancer1995，72，1： | 1 |
| 5 | ME-PCR for the identification of mutated K-ras in serum and bile of pancreatic cancer patients: an unsatisfactory technique for clinical applications显示文摘 | Carlo-Federico Zambon Filippo Navaglia Daniela Basso Nicoletta Gallo Eliana Greco Maria Grazia Piva Paola Fogar Claudio Pasquali Sergio Pedrazzoli Mario Plebani | 2000 | Clinica Chimica Acta2000，，1： | 1 |
| 6 | Pro-and anti-inflammatory eytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome显示文摘 | Zambon CF Basso D Navaglia F | 2005 | Cytokine2005，29，4： | 1 |
| 7 | Clinical evaluation of seven tumour markers in lung cancer diagnosis: can any combination improve the results显示文摘 | Plebani M Basso D Navaglia F | 1995 | Br J Cancer1995，72，1： | 1 |
| 8 | Pro-and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection:interactions influence outcome显示文摘 | Zambon CF Basso D Navaglia F | 2005 | Cytokine2005，29，4： | 1 |
| 9 | Non-invasive diagnosis of Helicobacter pylori infection: simplified 13Curea breath test,stool antigen testing or DNA PCR in human faeces in a clinical laboratory setting显示文摘 | Zambon CF Basso D Navaglia F Mazza S Razetti M Fogar P | 2004 | Clin Biochem2004，37，4： | 1 |
| 10 | Pro- and anti-in- flammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome显示文摘 | Zambon CF Basso D Navaglia F | 2005 | Cytokine2005，29，4： | 1 |
| 11 | Clinial evaluation of seven tumour markers in ling cancer diagnosis:can any combination improve the results显示文摘 | Plebani M Basso D Navaglia F | 1995 | Br J cancer1995，72，1： | 1 |
| 12 | Clinical evaluation of seven tumor markers in lung cancer diagnosis:Can any combina- tion improve the results 显示文摘 | Plebani M Basso D Navaglia F | 2005 | Br J Cancer2005，72，1： | 1 |
| 13 | Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome显示文摘 | Carlo-F. Zambon Daniela Basso Filippo Navaglia Claudio Belluco Alessandra Falda Paola Fogar Eliana Greco Nicoletta Gallo Massimo Rugge Francesco Di Mario Mario Plebani | 2004 | Cytokine2004，，4： | 1 |
| 14 | Pro-and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection:interactions influence outcome显示文摘 | Zambon CF Basso D Navaglia F | 2005 | Cytokine2005，29，4： | 1 |
| 15 | Clinial evalution of seven tumour markers in lung cancer diagnosis: can any combination im prove the results显示文摘 | Plebani M Basso D Navaglia F | 1995 | Br J Cancer1995，72，1： | 1 |
| 16 | Interleukin 12 gene polymorphisms enhance gastric cancer risk in Helicobacter pylori infected individuals显示文摘 | Navaglia F Basso D Zambon CF | 2005 | J Med Genet2005，42，6： | 1 |
| 17 | Antigastric autoantibodies inHelicobacter pylori infection: role in gastric mucosal inflammation显示文摘 | D. Basso N. Gallo C. -F. Zambon M. Baron F. Navaglia E. Stockreiter F. Mario M. Rugge M. Plebani | 2000 | International Journal of Clinical & Laboratory Research2000，，4： | 1 |
| 18 | CEA mRNA identification in peripheral blood is feasible for colorectal, but not for gastric or pancreatic cancer staging显示文摘 | Piva MG Navaglia F Basso D | 2000 | Oncology2000，59，4： | 1 |
| 19 | Pro-and anti -inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome 显示文摘 | Zambon CF Basso D Navaglia F | 2005 | C ytokine2005，29，4： | 1 |
| 20 | Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of- flight mass spectrometry显示文摘 | Navaglia F Fogar P Basso D | 2009 | Clin Chem Lab Med2009，47，： | 1 |
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