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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure显示文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P<0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation. | Necdet Guler Omer Unalp Ayse Guler Onur Yaprak Murat Dayangac Murat Sozbilen Murat Akyildiz Yaman Tokat | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 9 |
| 3 | The Effect of Atmospheric Pressure Plasma Corona Discharge on pH, Lipid Content and DNA of Bacterial Cells显示文摘Effect of plasma corona discharges on the pH,whole cell lipids and DNA of bacteriais investigated.Results showed an increase in the acidity levels of water due to plasma reactivespecies which,however,were not responsible for bacterial cell death.No changes in the wholecell lipid contents were observed,while DNA after plasma treatment showed deterioration ofthe amplified sequences,indicating the possible occurrence of DNA degradation.In conclusion,reactive species produced by plasma discharges affects DNA,possibly contributing to cell death. | May KORACHI Necdet ASLAN | 2011 | Plasma Science and Technology2011，13，1： | 3 |
| 4 | Major complications of adult right lobe living liver donors显示文摘BACKGROUND:The right lobe of the liver is generally preferred for living donor liver transplantation in adult patients with end-stage liver disease.It is important to know the preoperative factors relating to the major postoperative complications.We therefore evaluated the possible risk factors for predicting postoperative complications in right lobe liver donors.METHODS:Data from 378 donors who had undergone | Necdet Guler Onur Yaprak Yusuf Gunay Murat Dayangac Murat Akyildiz Fisun Yuzer Yildiray Yuzer Yaman Tokat | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 5 | Horizontal transmission of hepatitis B virus in children with chronic hepatitis B显示文摘AIM: To determine the possible routes of intrafamilial transmission pattern in pediatric cases of chronic hepatitis B virus (HBV) infection.METHODS: In this descriptive retrospective study, 302 children with chronic HBV infection from 251 families and their parents attending the Social Security Children's Hospital and Doctor Sami Ulus Children's Hopsital in Ankara between December 1998 and May 2000, were enrolled in. Screenings and diagnosis of chronic HBV infections were established according to the Consensus 2000.RESULTS: In the studied 302 children with chronic HBV infection, mothers of 38% and fathers of 23% were HBsAg positive. The HBsAg positivity in at least two siblings of the same family was 61% when both parents were HBsAg positive.CONCLUSION: It is well known that horizontal transmission is quite common in countries where Hepatitis B Virus is moderately endemic. To our best knowledge, this is the largest series observed regarding the horizontal transmission in pediatric chronic HBV infection in Turkey. It is necessary to expand the preventive programs to target not only the newborn period but also all stages of childhood. | Tumay Doganci Gulnar Uysal Tayfun Kir Arzu Bakirtas Necdet Kuyucu Levent Doganci | 2005 | World Journal of Gastroenterology2005，11，3： | 2 |
| 6 | Water quality monitoring network design:A problem of multi-objective decision making显示文摘 | Nilgun B Harmancioglu Necdet Alpaslan | 1992 | Water Resources Bulletin1992，28，1： | 1 |
| 7 | Pathological and ultrastructural studies on mucoid enteropathy in New Zealand rabbits显示文摘 | MEHMET H OZLEM O NECDET D | 2009 | J Exot Pet Medi2009，18，3： | 1 |
| 8 | Stress and Displacement Distribu- tions on Cylindrical Roller Bearing Rings Using FEM 显示文摘 | Necdet D Bahattin K | 2008 | Mechanics Based Design of Structures and Ma - chines: An International Journal2008，36，1： | 1 |
| 9 | Impact of sex hormonal changes on tension-type headache and migraine:a cross-sectional population-based surveyin 2600 women显示文摘 | Necdet Karl覦 Betu Baykan Mustafa Ertas | | 0，，： | 1 |
| 10 | Micro push-out bond strengths of four fiber-reinforced composite post systems and 2 luting materials显示文摘 | Ayse D. Kececi B. Ureyen Kaya Necdet Adanir | 2008 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2008，，1： | 1 |
| 11 | cis-{ - ) -Methyl phenylglycidates inthe asymmetric synthesis of taxol side chain 显示文摘 | Mustafa Er Necdet Coskun | 2009 | ARKIVOC2009，12，： | 1 |
| 12 | Substituent Effect on the asymmetricinduction with ( lfi,2S, 5R )-and ( 15, 2R, 5S ) -mentholAuxiliaries显示文摘 | Mustafa Er Necdet Coskun | 2010 | J Chen Soc Pak2010，32，2： | 1 |
| 13 | Preschool education in Turkey in the European process 显示文摘 | Didem Kilic Gulsun Atanur Baskan Necdet Saglam | 2010 | Procedia Social and Behavioral Sciences2010，，9： | 1 |
| 14 | Heat transfer and thermal stress analysis in grooved tubes显示文摘 | VEYSEL O NECDET A | 2005 | Academy Proceedings in Engineering Sciences2005，30，4： | 1 |
| 15 | Neuroprotective effects of infliximab in experimental spinal cord ischemic injury显示文摘 | Cagatay Guven Alp Ozgun Borcek Berker Cemil Gokhan Kurt Zuhal Yildirim Nese Lortlar Ucankus Nedret Kilic Necdet Ceviker | 2010 | Journal of Clinical Neuroscience2010，，12： | 1 |
| 16 | Neuroprotective effects of infliximab in experimental spinal cord injury显示文摘 | G?khan Kurt Ertan Ergün Berker Cemil Alp ?zgün B?rcek Pelin B?rcek ?zlem Gülbahar Necdet ?eviker | 2009 | Surgical Neurology2009，，3： | 1 |
| 17 | Stress Analysis of a Maxillary Central Incisor Restored with Different Posts显示文摘 | Necdet Adanir Sema Belli etal | 2007 | European Journal of Dentistry2007，4，1： | 1 |
| 18 | On some properties of digamma and polygamma functions 显示文摘 | Necdet Batir | 2007 | Journal of Mathematical Analysis and Applications2007，328，1： | 1 |
| 19 | Aricuhural recycling of treatment - plant sludge : a case study for a vegetable processing factory 显示文摘 | Deniz dolgen M Necdet Alpaslan Nafiz Delen | 2007 | Journal Environmental Management2007，84，： | 1 |
| 20 | Stress and displacement distributions on cylindrical roller bearing rings using FEM显示文摘 | Necdet D Bahattin K | 2008 | Mechanics Based Design of Structures & Machines2008，36，1： | 1 |
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