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| 1 | Molecular genetics and targeted therapeutics in biliary tractcarcinoma显示文摘The primary malignancies of the biliary tract, cholangio-carcinoma and gallbladder cancer, often present at an advanced stage and are marginally sensitive to radiation and chemotherapy. Accumulating evidence indicates that molecularly targeted agents may provide new hope for improving treatment response in biliary tract carcinoma(BTC). In this article, we provide a critical review of the pathogenesis and genetic abnormalities of biliary tract neoplasms, in addition to discussing the current and emerging targeted therapeutics in BTC. Genetic studies of biliary tumors have identified the growth factors and receptors as well as their downstream signaling pathways that control the growth and survival of biliary epithelia. Target-specific monoclonal antibodies and small molecules inhibitors directed against the signaling pathways that drive BTC growth and invasion have been developed. Numerous clinical trials designed to test these agents as either monotherapy or in combination with conventional chemotherapy have been completed or are currently underway. Research focusing on understanding the molecular basis of biliary tumorigenesis will continue to identify for targeted therapy the key mutations that drive growth and invasion of biliary neoplasms. Additional strategies that have emerged for treating this malignant disease include targeting the epigenetic alterations of BTC and immunotherapy. By integrating targeted therapy with molecular profiles of biliary tumor, we hope to provide precision treatment for patients with malignant diseases of the biliary tract. | Eric I Marks Nelson S Yee | 2016 | World Journal of Gastroenterology2016，22，4： | 13 |
| 2 | Immunotherapeutic approaches in biliary tract carcinoma:Current status and emerging strategies显示文摘For biliary tract carcinoma(BTC),complete surgical resection of tumor is only feasible in a minority of patients,and the treatment options for patients with unresectable or metastatic disease are limited.Advances in cancer immunology have led to identification of tumor-infiltrating immune cells as indicators of prognosis and response to treatment in BTC.This has also facilitated development of immunotherapy that focuses on enhancing the immune system against biliary tumors.This includes peptide- and dendritic cell-based vaccines that stimulate in-vivo immune responses against tumorspecific antigens.Adoptive immunotherapy,which entails the ex-vivo expansion of tumor-infiltrating immune cells for subsequent reintroduction,and cytokinebased therapies have been developed in BTC.Clinical studies indicate that this type of therapy is generally well tolerated.Combination therapy with dendritic cell-based vaccines and adoptive immunotherapy has shown particularly good potential.Emerging strategies through discovery of novel antigen targets and by reversal of tumor-associated immunosuppression are expected to improve the efficacy of immunotherapy in BTC.Collaborative efforts by integration of targeted immunotherapeutics with molecular profiling of biliary tumor will hopefully make a positive impact on advancing towards the goal of developing precision treatment of patients with this highly lethal disease. | Eric I Marks Nelson S Yee | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 11 |
| 3 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 4 | The evolution of epidemic influenza 显示文摘 | Nelson M I Holmes E C | 2007 | Nat Rev Genet2007，8，3： | 1 |
| 5 | Ignition properties of thermally thin thermoplastic-the effectiveness of inert additives in reducing flammability显示文摘 | Nelson M I Brindley J McIntosh A C | 1996 | Polym Degrad Stab1996，54，23： | 1 |
| 6 | Illinois process for preparation of soymilk显示文摘 | Nelson A I Steinberg M P Wei L S | 1976 | Food Sci1976，41，1： | 1 |
| 7 | Vascular lesions in pigs experimentally infected with porcine circovirus type 2 serogroup B显示文摘 | Langohr I M Stevenson G W Nelson E A | 2010 | Vet Pathol2010，47，1： | 1 |
| 8 | Dynamic seismic analysis of long segmented lifeline显示文摘 | Nelson I Weidlinger P | 1979 | J of Pressure Vessel Technology1979，101，1： | 1 |
| 9 | Ignition of thermally thin thermoplastics-the effectiveness of inert additives in reducing flammability 显示文摘 | Nelson M I Brindley J Mc Intosh A C | 1996 | Polym Degrad Stab1996，54，： | 1 |
| 10 | Home delivery of heat-stable vaccines in Indonesia:outreach immunization with a prefilled,singe-use injection device显示文摘 | Suatnato A Suarnawa I M Nelson C M | 1999 | Bull WHO1999，77，2： | 1 |
| 11 | Pyrosequencing the transcriptome of the greenhouse whitefly,trialeurodes vaporariorum reveals multiple transcripts encoding insecticide targets and detoxifying enzymes显示文摘 | Karatolos N Pauchet Y Wilkinson P Chauhan R Denholm I Gorman K Nelson D R Bass C Ffrench-Constant R H Williamson M S | | 0，，： | 1 |
| 12 | Continuing warfarin thera-py is superior interrupting warfarin with or without bridging anti- coagulation therapy in patients undergoing pacemaker and defib- rillator implantation显示文摘 | Ahmed I Genner E Nelson WB | 2010 | Heart Rhythm2010，7，： | 1 |
| 13 | The pipeline embolization device for the intracranial treatment of aneurysms trial显示文摘 | Nelson PK Lylyk P Szikora I | 2011 | AJNR Am J Neuroradiol2011，32，1： | 1 |
| 14 | The formation of pyrene: cyclomalto-oligosaccharide complexes in the presence of non-ionic surfactants显示文摘 | NELSON G WARNER I M | 1989 | Carbohydr Res1989，192，： | 1 |
| 15 | Serotonin(5-hydroxytryptamine)transporter inhibition causes bone loss in adult mice independently of estrogen deficiency显示文摘 | Warden S J Nelson I R Fuchs R K | 2008 | Menopause2008，15，6： | 1 |
| 16 | Climate change and hazard zonation in the Circum-Arctic permafrost regions 显示文摘 | Nelson F E Anisimov O A Shiklomanov N I | 2002 | Natural Hazards2002，26，： | 1 |
| 17 | Validation of cardiovascu- lar magnetic resonance assessment of pericardial adipose tissue vol- ume显示文摘 | Nelson A J Worthley M I Psahis P J | 2009 | J Cardiovasc Magn Reson2009，11，： | 1 |
| 18 | Home delivery of heat-stable vaccines in Indonesia ;outreach immunization with a prifilled,single-use injection device显示文摘 | Sutanto A Suarnawa I M Nelson C M | 1999 | Bull WHO1999，77，2： | 1 |
| 19 | Treods and Random Walks in Macroeconomic Time Series:Some Evidence and Implications 显示文摘 | Nelson C R Plosser C I | 1982 | Journal of Monetary Economics1982，，10： | 1 |
| 20 | Frequency-narrowed diode array bar 显示文摘 | E Babcock B Chann I A Nelson | 2005 | Applied Optics2005，44，15： | 1 |
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