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| 1 | 在心血管的疾病的先进 glycation 结束产品的角色显示文摘 Advanced glycation end products(AGEs) are produced through the non enzymatic glycation and oxidation of proteins,lipids and nucleic acids.Enhanced formation of AGEs occurs particularly in conditions associated with hyperglycaemia such as diabetes mellitus(DM).AGEs are believed to have a key role in the development and progression of cardiovascular disease in patients with DM through the modif ication of the structure,function and mechanical properties of tissues through crosslinking intracellular as well as extracellular matrix proteins and through modulating cellular processes through binding to cell surface receptors [receptor for AGEs(RAGE)].A number of studies have shown a correlation between serum AGE levels and the development and severity of heart failure(HF).Moreover,some studies have suggested that therapies targeted against AGEs may have therapeutic potential in patients with HF.The purpose of this review is to discuss the role of AGEs in cardiovascular disease and in particular in heart failure,focussing on both cellular mechanisms of action as well as highlighting how targeting AGEs may represent a novel therapeutic strategy in the treatment of HF. | Zeinab Hegab Stephen Gibbons Ludwig Neyses Mamas A Mamas | 2012 | World Journal of Cardiology2012，4，4： | 58 |
| 2 | Ca^(2+) signalling in cardiovascular disease:the role of the plasma membrane calcium pumps显示文摘The plasma membrane calcium ATPases(PMCA) are a family of genes which extrude Ca2+from the cell and are involved in the maintenance of intracellular free calcium levels and/or with Ca2+signalling,depending on the cell type.In the cardiovascular system,Ca2+ is not only essential for contraction and relaxation but also has a vital role as a second messenger in signal transduction pathways.A complex array of mechanisms regulate intracellular free calcium levels in the heart and vasculature and a failure in these systems to maintain normal Ca2+homeostasis has been linked to both heart failure and hypertension.This article focuses on the functions of PMCA,in particular isoform 4(PMCA4) ,in the heart and vasculature and the reported links between PMCAs and contractile function,cardiac hypertrophy,cardiac rhythm and sudden cardiac death,and blood pressure control and hypertension.It is becoming clear that this family of calcium extrusion pumps have essential roles in both cardiovascular health and disease. | Elizabeth J.CARTWRIGHT Delvac OCEANDY Clare AUSTIN Ludwig NEYSES | 2011 | Science China(Life Sciences)2011，54，8： | 12 |
| 3 | Atrial fibrillation in heart failure: The sword of damocles revisited显示文摘Heart failure (HF) and atrial fibrillation (AF) frequently coexist and have emerged as major cardiovascular epidemics. There is growing evidence that AF is an independent prognostic marker in HF and affects patients with both reduced as well as preserved LV systolic function. There has been a general move in clinical practice from a rhythm control to a rate control strategy in HF patients with AF, although recent data suggests that rhythm control strategies may provide better outcomes in selected subgroups of HF patients. Furthermore, various therapeutic modalities including pace and ablate strategies with cardiac resynchronisation or radio-frequency ablation have become increasingly adopted, although their role in the management of AF in patients with HF remains uncertain. This article presents an overview of the multidimensional impact of AF in patients with HF. Relevant literature is highlighted and the effect of various therapeutic modalities on prognosis is discussed. Finally, while novel anticoagulants usher in a new era in thromboprophylaxis, research continues in avariety of new pathways including selective atrial anti-arrhythmic agents and genomic polymorphisms in AF with HF. | Muhammad A Khan Fozia Ahmed Ludwig Neyses Mamas A Mamas | 2013 | World Journal of Cardiology2013，5，7： | 4 |
| 4 | Calcium transport in cardiovascular health and disease-the sarcolemmal calcium pump enters the stage显示文摘 | Cartwright EJ Schuh K Neyses L | 2005 | J Mol Cell Cardiol2005，39，： | 1 |
| 5 | Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria显示文摘 | Jazbutyte V Kehl F Neyses L | | 0，，： | 1 |
| 6 | Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet显示文摘 | Oceandy D Cartwright EJ Neyses L | 2009 | Trends Cardiovasc Med2009，19，8： | 1 |
| 7 | Combined SSCP and heteroduplex analysis of the human plasma membrane Ca\{2+\}-ATPase isoform 1 in patients with essential hypertension显示文摘 | Benkwitz C Oberdorf MS Neyses L | 1999 | Biochem Biophys Res Commun1999，261，： | 1 |
| 8 | Diuretic usage in heart failure: a continuing conundrum in 2005显示文摘 | Gupta S Neyses L | 2005 | Eur Heart J2005，26，7： | 1 |
| 9 | The molecular basis of myocardial hypertrophy and heart failure显示文摘 | Ritter O Neyses L | 2003 | Trends Moi Med2003，9，7： | 1 |
| 10 | Diuretic usage in heart failure:a continuing conundrum in 2005显示文摘 | Gupta S Neyses L | 2005 | Eur Heart J2005，26，7： | 1 |
| 11 | Targeting the sarcolemmal calcium pump: a potential novel strategy for the treatment of cardiovascular disease 显示文摘 | OCEANDY D MAMAS M A NEYSES L | 2007 | Cardiovase Hematol Agents Med Chem2007，5，4： | 1 |
| 12 | Action of atrial natriuretic peptide and angiotensin II on the myocardium:studies in isolated rat ventricular cardiomyocytes显示文摘 | Neyses L Vetter H | 1989 | Biochem Biophys Res Commun1989，163，： | 1 |
| 13 | Diuretic usage in heart failure: a continuing conundrum in 2005 显示文摘 | Gupta S Neyses L | 2005 | Eur Heart J2005，26，7： | 1 |
| 14 | The biological cascade leading to cardiac hypertrophy显示文摘 | Neyses L Pelzer T | 1995 | Eur Heart J1995，16，： | 1 |
| 15 | The molecular basis of myocardial hypertrophy and heart failure 显示文摘 | Ritter O Neyses L | 2003 | Trends Mol Med2003，9，7： | 1 |
| 16 | Cyclohexane oxidation withtertiary-butylhydroperoxide catalysed iron-phthalocyanines homogeneously and occluded in Y zeolite显示文摘 | Parton R F Peere G J Neys P E | | 0，，： | 1 |
| 17 | Plasma membrane calcium ATPase proteins as novel regulators of signal transduction pathways显示文摘Emerging evidence suggests that plasma membrane calcium ATPases (PMCAs) play a key role as regulators of calcium-triggered signal transduction pathways via interaction with partner proteins. PMCAs regulate these pathways by targeting specific proteins to cellular sub-domains where the levels of intracellular freecalcium are kept low by the calcium ejection properties of PMCAs. According to this model, PMCAs have been shown to interact functionally with the calcium-sensitive proteins neuronal nitric oxide synthase, calmodulindependent serine protein kinase, calcineurin and endothelial nitric oxidase synthase. Transgenic animals with altered expression of PMCAs are being used to evaluate the physiological significance of these interactions. To date, PMCA interactions with calcium-dependent partner proteins have been demonstrated to play a crucial role in the pathophysiology of the cardiovascular system via regulation of the nitric oxide and calcineurin/nuclear factor of activated T cells pathways. This new evidence suggests that PMCAs play a more sophisticated role than the mere ejection of calcium from the cells, by acting as modulators of signaling transduction pathways. | Mary Louisa Holton Michael Emerson Ludwig Neyses Angel L Armesilla | 2010 | World Journal of Biological Chemistry2010，1，6： | 1 |
| 18 | The role of metabolites andmetaholomics in clinically applicable biomarkers of disease 显示文摘 | Mamas M Dunn WB Neyses L | 2011 | Arch Toxicol2011，85，1： | 1 |
| 19 | Combined SSCP and beteroduplex analysis of the human plasma membrane isoform 1 in patients with essential hypertension 显示文摘 | Benkwitz C Oberdorf MS Neyses L | 1999 | Biochem Biophys Res Commun1999，261，： | 1 |
| 20 | Estrogen effects in the heart显示文摘 | Pelzer T Shamim A Neyses L | 1996 | Mol Cell Biochem1996，，： | 1 |
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