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| 1 | Epigallocatechin-3-gallate (EGCG) attenuates nflammation in MRL/Ipr mouse mesangial cells显示文摘 | Abigail Peairs Rujuan Dai Lu Gan Samuel Shimp M Nichole Rylander Liwu Li Christopher M Reilly | 2010 | Cellular & Molecular Immunology2010，7，2： | 12 |
| 2 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 3 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 4 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 5 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 6 | Performances of Concrete under Elevated Curing Temperature显示文摘The behaviors of concrete at elevated curing temperature were studied. The test results show that when concrete is cured at elevated temperature, a harmful consequence occurs.The later strength decreases significantly compared to that under normal curing condition. Incorporating silica fume, fly ash and slag or lowering w/c ratio can effectively alleviate this harmful consequence. Comparatively, incorporation of silica fume is the most efficient means to decrease the later strength reduction. The harmful consequence is not caused by the difference in degree of hydration since the degree of hydration is similar between elevated curing temperature and normal curing condition. The SEM analysis shows that it is the uneven distribution of hydration products caused by elevated curing temperature that leads to the later strength reduction of concrete. | 谭克锋 John M Nichols | 2004 | Journal of Wuhan University of Technology(Materials Science)2004，19，3： | 2 |
| 7 | Twentieth century trends in climate extremes over the Australian region and New Zealand 显示文摘 | Plummer N Salinger M J Nicholls N | 1999 | Climatic Change1999，42，1： | 1 |
| 8 | Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice显示文摘 | Chou M W Yan J Nichols J | 2003 | Cancer Lett2003，193，： | 1 |
| 9 | Possible spin polarization in a one-dimensional electron gas 显示文摘 | THOMAS K J NICHOLLS J T SIMMONS M Y | 1996 | Physical Review Letters1996，77，1： | 1 |
| 10 | Separation of Eperythrozoon ovis from erythrocytes显示文摘 | Lang F M Ferrier G R Nicholls T J | 1986 | Vet Rec1986，119，： | 1 |
| 11 | Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb 显示文摘 | Li Yan Nichols M A Shay J W | 1994 | Cancer Res1994，54，23： | 1 |
| 12 | Intrauterine lidocaine infusion for pain management in first-trimester abortions显示文摘 | EDELMAN A NICHOLS M D LECLAIR C | 2004 | Obstet Gynecol2004，103，6： | 1 |
| 13 | Glueoeortiecid regulation of glial responses during hippocampal neurodegeneration and regeneration显示文摘 | Nichols NR Agolley D Zieba M | | 0，，： | 1 |
| 14 | Effect of two intensive statin regimens on progression of coronary disease 显示文摘 | NICHOLLS S J BALLANTYNE C M BARTER P J | 2011 | N Engl J Med2011，365，22： | 1 |
| 15 | Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis显示文摘 | Balamuth NJ Nichols KE Paessler M | 2007 | J Pediatr Hematol Oncol2007，29，： | 1 |
| 16 | 查看详情显示文摘 | Renoncourt A Bauduin P Nicholl E Touraud D Verbavatz J.M Dubois M Drechsler M Kunz W | | 0，，： | 1 |
| 17 | A comparisonbetween the erosion behaviour of thermal spray andelectron beam physical vapour deposition thermal barriercoatings显示文摘 | Nicholls J R Deakin M J Rickerby D S | 1999 | Wear1999，，233235： | 1 |
| 18 | Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: a pooled analysis of 5 intravascular ultrasound trials显示文摘 | Nicholls S J Tuzcu E M Kalidindi S Wolski K Moon K W Sipahi I | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 19 | Contribution of posture to anorectal manometric measurements:are the measurements in left-lateral position physiologic?显示文摘 | Thekkinkattil D K Lim M K Nicholls M J | 2007 | Dis Colon Rectum2007，50，12： | 1 |
| 20 | Reducing medical errors through barcoding at the point of care显示文摘 | Nichols JH Bartholomew C Bmnton M | 2004 | Clin Leadersh Manag Rev2004，18，6： | 1 |
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