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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 3 | Farming for metals显示文摘 | Nicks L J Chambers M F | 1995 | Mining Environmental Management1995，3，3： | 1 |
| 4 | Environmental policy,innovation and performance:new insights on the Porter hypothesis显示文摘 | PAUL L JEREMY L NICK L | 2011 | Journal of Economics&Management Strategy2011，20，3： | 1 |
| 5 | Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia显示文摘 | KEITH SJ PANI L NICK B | 2004 | Psychiatr Serv2004，55，55： | 1 |
| 6 | Digital watermarking using complex wavelets显示文摘 | PATRICK L NICK K | 2000 | IEEE Transactions on Signal Processing2000，2，3： | 1 |
| 7 | Activation of NADPH oxidase during progression of cardiac hypertrophy to failure显示文摘 | Jian-Mei L Nick PG David JG | 2002 | Hypertension2002，40，： | 1 |
| 8 | Prostatitis:Lessons from the 20th Century显示文摘 | Nicke l JC | 2000 | BJU Int2000，85，： | 1 |
| 9 | Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer显示文摘 | HEASLEY L E THALER S NICKS M | 1997 | J Biol Chem1997，272，14： | 1 |
| 10 | Practical application of pharmacothe- rapy with long - acting rispefidone for patients with schizophrenia 显示文摘 | Keith SJ Pani L Nick B | 2004 | Psychiatr Serv2004，55，： | 1 |
| 11 | Mobile IP: internet speed bump显示文摘 | | 1998 | Data Communication1998，27，14： | 1 |
| 12 | Farming for metal显示文摘 | Nicks L J Chambers M F | 1995 | Mining environmental management1995，，3： | 1 |
| 13 | Pharmacokinetics of florfenicol after intravenous and intramuscular dosing in llamas显示文摘 | Rebecca L Pentecost Andrew J Niehaus Nick A Werle | 2013 | Research in Veterinary Science2013，，2： | 1 |
| 14 | Genomic regions determining resistance to leaf stripe (Pyrenophora graminea ) in barley显示文摘 | Arru L Nicks R E Lindhout P | 2002 | Genome2002，45，： | 1 |
| 15 | Phyto-mining显示文摘 | Brooks R R Chambers M F Nicks L J | 1998 | Trends in Plant Sci1998，3，： | 1 |
| 16 | Genetic variation for phenotypically invariant traits detected in teosinte: implications for the evolution of novel forms 显示文摘 | Nick L John D | 2002 | Genetics2002，160，： | 1 |
| 17 | Activation of NADPH oxidase during progression of cardiac hypertrophy to failure显示文摘 | JIAN M L NICK P G DAVID J G | 2002 | Hypertension2002，40，4： | 1 |
| 18 | Paraneoplastie thromboey- tosis in ovarian cancer 显示文摘 | Stone R L Nick A M MeNeish I A | 2012 | N Engl J Meal2012，，366： | 1 |
| 19 | Grid services for distributed system integration显示文摘 | Foster l Kesselman C Nick J | 2002 | Computer2002，35，6： | 1 |
| 20 | Hypoplasia of the aortic root: The problem of nortiv valve replacement显示文摘 | NICKS R CARTMILL T BERNSTEIN L | 1970 | Thorax1970，25，： | 1 |
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