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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 3 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 4 | New blocking antibodies impede adhesion,migrationand survival of ovarian cancer cells,highlighting MFGE8 as a potential therapeutic target of human Ovarian Carcinoma显示文摘 | Tibaldi L Leyman S Nicolas A | 2013 | PloS One2013，8，72： | 1 |
| 5 | 显示文摘 | Trouillet L Nicola A D Guillerez S | 2000 | Chem Mater2000，12，6： | 1 |
| 6 | Deformation by a kink mechanism in high temperature materials显示文摘 | NICOLAOU P D SEMIATIN S L | 1999 | Acta Materialia1999，47，： | 1 |
| 7 | Measurements and correlations of cis-1, 3, 3, 3-tetrafluoroprop-l-ene (R1234ze (Z)) subcooled liquid density and vapor-phase PvT显示文摘 | Fedele L Brown J S Di Nicola G | 2014 | International Journal of Thermophysics2014，35，8： | 1 |
| 8 | An analysis of the effect of continuous nucleation and coalescence on cavitation during hot tension testing显示文摘 | NICOLAOU P D SEMIATIN S L | 2000 | Acta Materialia2000，48，： | 1 |
| 9 | Essential role for caspase-8 in Toll-like receptors and NF kappa B signaling显示文摘 | Benedicte L Leonardo S Nicolas B | 2007 | Biol Chem2007，282，： | 1 |
| 10 | Surface versus bulk nucleation of dislocations during contact显示文摘 | Nicola L Bower A F Kim K S | 2007 | Journal of the mechanics and physics of solids2007，55，： | 1 |
| 11 | Adsotption of ala- chlor by humic acids from sewage sludge and amended and non-amended soils 显示文摘 | Nicola S Gennaro B Polo L C | 1994 | Soil Science1994，157，3： | 1 |
| 12 | New Interspinous Implant Evaluation Using an In Vitro Biomechanical Study Combined With a Finite-Element Analysis 显示文摘 | Virginie L Nicolas G Jacques S | 2007 | SPINE2007，32，16： | 1 |
| 13 | Progesterone treatment of spinal cord injury:Effects on receptors,neurotrophins,and myelination显示文摘 | DE NICOLA A F GONZALEZ S L LABOMBARDA F | 2006 | J Mol Neurosci2006，28，1： | 1 |
| 14 | A Practical Criterion for the Rapid Detection of Single‐Loop and Double‐Loop Reentry Tachycardias显示文摘 | NICK W.F. LINTON STEPHEN B. WILTON DANIEL SCHERR ASHOK J. SHAH NICOLAS DERVAL FREDERIC SACHER MATTHEW WRIGHT MéLèZE HOCINI MARK D. O’NEILL MICHEL HA?SSAGUERRE PIERRE JA?S | 2013 | J Cardiovasc Electrophysiol2013，，5： | 1 |
| 15 | Design of Symmetric Conic--section Flexure Hinges Based on Closed-form Compliance Equations显示文摘 | Nicolae L Jeffrey S N P Ephrahim G | 2002 | Mechanism and Machine Theory2002，37，5： | 1 |
| 16 | Some Recent Advancesin the Design and the Use of Miniaturized Droplet-BasedContinuous Process:Applications in Chemistry and High-Pressure Microflows显示文摘 | Nicolas L Flavie S Pierre G | 2011 | Lab on a Chip2011，11，： | 1 |
| 17 | 查看详情显示文摘 | Geng J Mantovani G Tao L Nicolas J Chen G Wallis R Mitchell D A Johnson B R G Evans S D Haddleton D M | | 0，，49： | 1 |
| 18 | Stoichiometric interpretations of C: N: P Ratios in organic waste materials显示文摘 | Diego-Mcglone M L S Smith S V Nicolas V F | 2000 | Marine pollution bulletin2000，40，4： | 1 |
| 19 | Interactions of abscisic acid and sugar signalling in the regulation of leaf senescence显示文摘 | Nathalie Pourtau Magali Marès Sarah Purdy Nicolas Quentin Alexandra Ru?l Astrid Wingler | 2004 | Planta2004，，5： | 1 |
| 20 | Feline antioxidant enzyme activity:The effect of sample storage on stability显示文摘 | MARK D M SAMANTHA L W NICOLA D S | 2002 | The Journal of Nutrition2002，132，： | 1 |
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