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| 1 | Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration显示文摘End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps,compared to repairs with a graft.However,grafts are typically used to enable a tension-free repair for moderate to large gaps,as excessive tension can cause repairs to fail and catastrophically impede recovery.In this study,we tested the hypothesis that unloading the repair interface by redistributing tension away from the site of repair is a safe and feasible strategy for end-to-end repair of larger nerve gaps.Further,we tested the hypothesis that such an approach does not adversely affect structural and functional regeneration.In this study,we used a rat sciatic nerve injury model to compare the integrity of repair and several regenerative outcomes following end-to-end repairs of nerve gaps of increasing size.In addition,we proposed the use of a novel implantable device to safely repair end-to-end repair of larger nerve gaps by redistributing tension away from the repair interface.Our data suggest that redistriubution of tension away from the site of repair enables safe end-to-end repair of larger gap sizes.In addition,structural and functional measures of regeneration were equal or enhanced in nerves repaired under tension – with or without a tension redistribution device – compared to tension-free repairs.Provided that repair integrity is maintained,end-to-end repairs under tension should be considered as a reasonable surgical strategy.All animal experiments were performed under the approval of the Institutional Animal Care and Use Committee of University of California,San Diego(Protocol S11274). | Holly M.Howarth Turki Alaziz Brogan Nicolds Shawn O'Connor Sameer B.Shah | 2019 | Neural Regeneration Research2019，14，7： | 2 |
| 2 | Acute ethanol treatment decreases intracellular calcium-ion transients in mouse single skeletal muscle fibers in vitro显示文摘 | Cofdn M Nicolds JM Ferndndez-sold J | 2000 | Alcohol Alcoholism2000，35，2： | 1 |
| 3 | Solution of temperature fields in hydrodynamics bearing by the nu-merical network method显示文摘 | Nicolds J A M De le6n Hijes F C G Alhama F | | 0，，01： | 1 |
| 4 | Epidemiological typing of clinically signi{icant strains of coagulase-negative staphylococci 显示文摘 | Martin de Nicolds M M Vindel A Offez Nieto J A | 1995 | Journal o{ Hospital Infection1995，29，1： | 1 |
| 5 | Transpiration and canopy conductance in young apricot (Prunus armenica L,) trees subjected to different PAR levels and water stress 显示文摘 | Barradas V L Nicolds E Torrecillas A | 2005 | Agricultural Water Management2005，77，1： | 1 |
| 6 | Characterization of metallocene EPDM terpolymers with high diene and propylene content crosslinkedby di- cumyl peroxide and β-radiation显示文摘 | Javier Nicold Jorge Ani hal Ressia Enrique Marcelo Valle | 2004 | Macromolecular Chemis- try and Physics2004，，205： | 1 |
| 7 | Water splitting proton-barriers for mineral mem- brane fouling control and their optimization by accurate pulsed modes of electrodialysis显示文摘 | Nicolds Cifuentes-Araya Gfrald Pourcelly Laurent Ba- zinet | 2013 | J Membr Sci2013，447，22： | 1 |
| 8 | Prone position for the treatment of acute respiratory distress syndrome: A review of current literature显示文摘 | oscar Martinez Nicolds Nin Andres Esteban | 2009 | Arch Bronconeumol2009，45，6： | 1 |
| 9 | Sap flow and trunk diameter fluctuations of young lemon trees under water stress and rewatering显示文摘 | Ortufio M F Alarcon J J Nicolds E | 2005 | Environmental and Exper- imental Botany2005，54，2： | 1 |
| 10 | Interpreting trunk diameter changes in young lemon trees under deficit irriaation显示文摘 | Ortufio M F Alarcon J J Nicolds E | 2004 | Plant Science2004，167，2： | 1 |
| 11 | Environmental factors affecting yield variability in spring and winter rapeseed genotypes cul- tivated in the southeastern Argentine Pampas显示文摘 | Nicolds E T Drborah P R Laura E P | | European Journal of Agronomy0，48，： | 1 |
| 12 | Bowenoid papulosis of penis显示文摘 | Bhojwani A Bitani CS Nicold A | 1997 | British J Urology1997，80，： | 1 |
| 13 | Androgens and androgen receptors in breast cancer 显示文摘 | Nicolds Dfaz-Chico B Germdn Rodriguez F Gonzdlez A | 2007 | J SteroidBiochem Mol Biol2007，105，15： | 1 |
| 14 | Recovery of infectious foot and-mouth disease virus from suckling mice after direct inoculation with in vitro-transcribed RNA显示文摘 | Eric B Nicolds Molina J I Nunez | 2003 | J Virol2003，77，11： | 1 |
| 15 | Pneumonia in ventilated head trauma patients: the role of thiopental therapy显示文摘 | Nadal P Nicolds JM Font C | 1995 | Eur J Emerg Med1995，2，1： | 1 |
| 16 | Ursodeoxyeholie acid treatment shortens the course of cholestasis in two patients with benign recurrent intrahepatic cholestasis显示文摘 | Nicolds I Ports J A Vargas A | 2003 | Gastroen- terol Hepatol2003，26，7： | 1 |
| 17 | Simvastatin inhibits the migration and adhesion of monocytie cells and disorganizes the cytoskeleton of activated endothelial cells显示文摘 | Pozo M de Nicolds R Egido J | 2006 | Eur J Pharmacol2006，548，13： | 1 |
| 18 | The plugging behaviour of driven and jacked piles in sand显示文摘 | NICOLD A RANDOLPH M F | 1997 | Geoteehnique1997，47，4： | 1 |
| 19 | Scaling up data mining algorithms: Review and taxonomy 显示文摘 | Nicolds Garcia Pedrajas Aida de Haro-Garcia | 2012 | Progress in Artificial Intelligence2012，1，1： | 1 |
| 20 | The plugging behaviour of driven and jacked piles in sand显示文摘 | NICOLD A RANDOLPH M F | 1997 | Geotechnique1997，47，4： | 1 |
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