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| 1 | Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. | Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo | 2001 | World Journal of Gastroenterology2001，7，2： | 2 |
| 2 | 日粮磷脂对大西洋鲑鱼早期发育和生长性能的影响显示文摘研究旨在证实大西洋鲑鱼对日粮磷脂的需求,更好地确定其需要水平和时期。因此,通过给大西洋鲑鱼提供磷虾或大豆卵磷脂探讨磷脂对其的影响。首先饲喂鱼苗含蛋白质55%和脂肪17%的饲粮,通过添加磷虾油或大豆磷脂补充脂肪.根据回归分析设计5个水平,分别为总磷脂1.5%(未添加)、2.6%、3.2%、3.6%和4.2%。在1g(受精后1400°dpf)、2.5g(1990°ape)、5g(2350°dpf)、10-20g(2850°dpf)和二龄鲑(3800°dpf)时进行取样。整体存活率高,说明存活率和饲粮磷脂添加水平呈正相关(r2=0.59—0.72)。磷脂促进了鱼苗的生长,且饲喂磷虾磷脂2.6%和大豆磷脂3.6%的鱼增长最快。鱼苗达到2.5g之前与之后生长模式不同,0-2.5g鱼补充磷虾磷脂2.6%和大豆磷脂3.6%后的生长速率(SGR)显著高于基础日粮(P〈0.05),而2.5g-二龄鲑期间,各处理之间没有差异。饲喂未补充磷脂的日粮,2.5g时发现鱼肠道脂肪变性,患病率达20%,饲喂低水平大豆磷脂日粮的鱼肠道脂肪变性患病率达10%,而喂食磷虾油和高水平大豆磷脂(≥3.2%)后以及在后期阶段,肠邋脂肪变性情况开始消失。在生命早期阶段,鲑鱼对日粮磷脂的要求是一致的。 | Taylor J F Martinez-Rubio L Pozo J D Walton J M Tinch A E Migaud H Tocher D R | 2015 | 饲料博览2015，0，8： | 2 |
| 3 | Treatment of anaerobic sludge digester effluents by the CANON process in an air pulsing SBR显示文摘 | J.R. Vázquez-Padín M.J. Pozo M. Jarpa M. Figueroa A. Franco A. Mosquera-Corral J.L. Campos R. Méndez | 2008 | Journal of Hazardous Materials2008，，1： | 2 |
| 4 | Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF kappaB显示文摘 | Pozo Guisado E Merino J M Mulero-Navarro S el al | 2005 | Int J Cancer2005，115，1： | 1 |
| 5 | Immunobiology of vasoactive intestinal peptide (VIP) 显示文摘 | Pozo D Delgado M Martinez M | 2000 | Immunol Today2000，21，1： | 1 |
| 6 | Treatment of anaerobic sludge digester effluents by the CANON process in an air pulsing SBR显示文摘 | Vazquez-Padin J R Pozo M J Jarpa M | 2009 | Journal of Hazardous Materials2009，166，1： | 1 |
| 7 | Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year r prospective study显示文摘 | Calvo C Pozo F Garcia-Garcia M L | 2010 | Acta Paediatrica2010，99，6： | 1 |
| 8 | Activa- tion of Racl by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression 显示文摘 | TZIMA E DEL POZO M A KIOSSES W B | 2002 | EMBO J2002，21，24： | 1 |
| 9 | A structural damage detection indicator based on principal component analysis and statistical hypothesis testing 显示文摘 | Mujica L E Ruiz M Pozo F | 2014 | Smart Materials and Structures2014，23，2： | 1 |
| 10 | A new energy-integrated pervaporation distillation approach显示文摘 | Del Pozo GOMEZ M T KLEIN A REPKE J | 2008 | Desalination2008，224，： | 1 |
| 11 | Microbial cooperation in the rhizosphere显示文摘 | BAREA J M POZO M J AZCON R | 2005 | Journal of Experimental Botany2005，56，417： | 1 |
| 12 | Tvbgn3,a beta-1, 6-glucanase from the biocontrol fungus Trichoderma virens, is in- volved in mycoparasitism and control of Pythium ultimum显示文摘 | DJONOVI C S POZO M J KENERLEY C M | 2006 | Ap- plied and Environmental Microbiology2006，72，12： | 1 |
| 13 | Characterization of a natural larger form of the antifungal protein (AFP) from Aspergillus giganteus显示文摘 | Martinez-Ruix A Martinez del Pozo A Lacadena J Mancheno J M Onaderra M Gavilanes J G | 1997 | Biochim Biophys Acta1997，1340，1： | 1 |
| 14 | Arabidopsis E2Fc functions in cell division and is degraded by the ubiquitin-SCF(At SKP2) pathway in response to light显示文摘 | DEL POZO J C BONIOTTI M B GUTIERREZ C | 2002 | Plant Cell2002，14，： | 1 |
| 15 | Functional analysis of tvspl,a serine protease-encoding gene in the biocontrol agent Trichoderma virens显示文摘 | Pozo M J Baek J M García J M | 2004 | Fungal Genet Biol2004，41，： | 1 |
| 16 | Three-dimensional finite element analysis of human temporomandibular joint with and without disc displacement during jaw opening 显示文摘 | Tanaka E del Pozo R Tanaka M | 2004 | Med Eng Phys2004，26，6： | 1 |
| 17 | Treatment of anaerobic sludge digester effluents by the CANON process in an air pulsing SBR 显示文摘 | Vazquez-Padin J R Pozo M J Jarpa M | 2009 | Journal of Hazardous Materials2009，166，1： | 1 |
| 18 | Application of mercury porosimetry to the study of xerogels used as stone consolidants显示文摘 | MOSQUERA M J POZO J ESQUIVIAS L | 2002 | Journal of Non -CrystaUine Solids2002，311，2： | 1 |
| 19 | Monitoring changes in the volatile profile of cheese crackers during storage using GC-MS and PTR-MS显示文摘 | POZO BAYON M A MARTIN ALVAREZ P J REINECCIUS G A | 2009 | Flavour and Fragrance Journal2009，24，3： | 1 |
| 20 | The significance of vasoactive intestinal peptide in immunomodulation 显示文摘 | Delgado M Pozo D Ganea D | 2004 | Pharmacol Rev2004，56，2： | 1 |
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