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| 1 | Natural history of hepatic metastases from colorectal cancer-pathobiological pathways with clinical significance显示文摘Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process.This process starts with a series of mutations in colonic epithelial cells,continues with their detachment from the large intestine,dissemination through the blood and/or lymphatic circulation,attachment to the hepatic sinusoids and interactions with the sinusoidal cells,such as sinusoidal endothelial cells,Kupffer cells,stellate cells and pit cells.The metastatic sequence terminates with colorectal cancer cell invasion,adaptation and colonisation of the hepatic parenchyma.All these events,termed the colorectal cancer invasion-metastasis cascade,include multiple molecular pathways,intercellular interactions and expression of a plethora of chemokines and growth factors,and adhesion molecules,such as the selectins,the integrins or the cadherins,as well as enzymes including matrix metalloproteinases.This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting. | Konstantinos A Paschos Ali W Majeed Nigel C Bird | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | Bacterial resistance modifying agents from Lycopus europaeus显示文摘 | Simon Gibbons Moyosoluwa Oluwatuyi Nigel C Veitch | | 0，，01： | 1 |
| 3 | Flavonol tetraglycosides and other constituents from leaves of Styphnolobiumjaponicum (Leguminosae) and related taxa显示文摘 | Geoffrey C Kite Charlotte A Sroneham Nigel C Veitch | 2007 | Phytochemistry2007，68，10： | 1 |
| 4 | Enhanced antibody response to liposome-associated protein antigens,preferential stimulation of IgG 2a/b production显示文摘 | Nigel P C Andrew E | 1992 | Vaccine1992，10，3： | 1 |
| 5 | Three-dimensional seismic geomorphology of a deep water slope channel system: The Sequoia field, offshore west Nile Delta, Egypt 显示文摘 | Nigel E C Alan C Robert J C | 2009 | AAPG Bulletin2009，93，8： | 1 |
| 6 | Flavonolignans from Hyparrhenia hirta显示文摘 | Mohamed B Nigel C | 2002 | Phytochemistry2002，60，： | 1 |
| 7 | Descriptive models of creative design: application to an example 显示文摘 | NIGEL C | 1997 | Design Studies1997，18，4： | 1 |
| 8 | Developing managerial learning styles in the context of the strategic application of information and communications technologies 显示文摘 | CLIVE H NIGEL C | 2001 | International Journal of Training & Development2001，5，1： | 1 |
| 9 | Diabetes-and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care : Continuous longitudinal monitoring using a standard method 显示文摘 | Ronan J Nigel C Villiam F | 2008 | Diabetes Care2008，31，3： | 1 |
| 10 | Editorial forty years of design research显示文摘 | NIGEL C | 2007 | Design Studies2007，28，1： | 1 |
| 11 | Idenrification of a plant nitric oxide synthase gene involved in hormonal signaling显示文摘 | GUO F Q MAMORU OKAMOTO NIGEL M C | 2003 | Science2003，302，： | 1 |
| 12 | The cyclic activated sludge system for resort area wastewater treatment显示文摘 | Goronsz M C Nigel S Dennis K | 1995 | Water Science Technology1995，32，9： | 1 |
| 13 | 3-D seismic geomorpholo-gy of a deepwater slope channel system:The Sequoia Field,Off-shore West Nile Delta,Egypt显示文摘 | Nigel E C Alan C Robert J C | 2009 | AAPG Bulletin2009，93，8： | 1 |
| 14 | Structure and regulation of acetyl-CoA carboxyiase genes of metazoa显示文摘 | MICHAEL C B NIGEL T P MAUREEN T T | 2005 | Biochimica Biophysica Acta2005，1733，： | 1 |
| 15 | Flavonol tetraglycosides from fruits of Styphnolobium japonicum(Leguminosae)and the authentication of Fructus Sophorae and Flos Sophorae显示文摘 | Geoffrey C Nigel C | 2009 | Phytochemistry2009，70，： | 1 |
| 16 | Protein quantification in the presence of poly (ethylene glycol) and dextran using the Bradford method 显示文摘 | Helder Barbosa Nigel K H Slater JoSo C Marcos | 2009 | Analytical Biochemistry2009，395，： | 1 |
| 17 | Flavonolignans from Hyparrhenia hirta显示文摘 | Mohamed B Nigel C V Renee J G | 2002 | Phytochemistry2002，60，： | 1 |
| 18 | High incidence of anticardiolipin antibodies in relatives of patients with systemic lupus erythematosus 显示文摘 | Charles MY John C Nigel H | 1987 | Rheumatol1987，14，： | 1 |
| 19 | Effect of thermal processing on anthocyanin stability in foods: mechanisms and kinetics of degradation 显示文摘 | ANK1T P NIGEL P BRUNTONA C | 2010 | Trends in Food Science & Technology2010，21，1： | 1 |
| 20 | Identifying managerial influences on exporting: Past research and future directions显示文摘 | eonidou L Katsikeas C Constantine S and Piercy Nigel F | 1998 | Journal of International Marketing1998，6，2： | 1 |
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