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| 1 | Antibiotic susceptibility profiling and virulence potential of Campylobacter jejuni isolates from different sources in Pakistan显示文摘Objective:To determine antibiotic resistance patterns and virulence potential of Campylobacter jejuni(C.jejuni) isolates from clinical human diarrheal infections,cattle and healthy broilers.Methods:Antibiotic sensitivity patterns of C.jejuni isolates were determined by Kirby Bauer Disc Diffusion assay.These isolates were then subjected to virulence profiling for the detection of map A(membrane-associated protein).cadF(fibronectin binding protein).wlaN(beta-1.3-galaclosyltransferase) and neu AB(sialic acid biosynthesis gene).Further C.jejuni isolates were grouped by random amplification of polymorphic DNA(RAPD) profiling.Results:A total of436 samples from poultry(n=88).cattle(n=216) and humans(n=132) from different locations were collected.Results revealed percentage of C.jejuni isolates were 35.2%(31/88).25.0%(54/216) and 11.3%(15/132) among poultry,cattle and clinical human samples respectively.Antibiotic susceptibility results showed that similar resistance patterns to cephalothin was ie.87.0%,87.1%and 89%among humans,poultry and cattle respectively,followed by sulfamethoxazolc+trimcthoprim 40.0%,38.7%and 31.0%in humans,poultry and cattle and Ampicillin 40%,32%and 20%in humans,poultry and cattle respectively.Beta-lactamase activity was detected in 40.00%humans.20.37%cattle and 32.25%in poultry C.jejuni isolates.CadF and mapA were present in all poultry,cattle and human C jejuni isolates.wlauN was not detected in any isolate and neu AB was found in 9/31(36%) poultry isolates.RAPD profiling results suggested high diversity of C.jejuni isolates.Conclusions:Detection of multidrug resistant C.jejuni strains from poultry and cattle is alarming as they can be potential hazard to humans.Moreover,predominant association of virulence factors,cadF and map A(100%each) in C.jejuni isolates from all sources and neuAB(36%) with poultry isolates suggest the potential source of transmission of diverse types of C.jejuni to humans. | Fariha Masood Siddiqui Muhammad Akram Nighat Nourccn Zobia Noreen Habib Bokhari | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，3： | 2 |
| 2 | New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids显示文摘 | Atta-ur-Rahman Khalid Asaad Sultana Nighat | 2006 | Journal of Enzyme Inhibition and Medicinal Chemistry2006，21，6： | 1 |
| 3 | Evaluation of antioxidant and antimicrobial activities of bergenin and its derivatives obtained by chemoenzymatic synthesis显示文摘 | Nighat Nazir Surrinder Koul Mushtaq Ahmad Qurishi | 2011 | Eur J Med Chem2011，46，： | 1 |
| 4 | Copyright for web content using invisible text wa- termarking 显示文摘 | Nighat Mir | 2014 | Computers in Human Behavior2014，，30： | 1 |
| 5 | Looking to the future:electrical stimulation for obesity显示文摘 | Thomas LA Anil M Nighat AP | 2006 | Am J Med Sci2006，331，4： | 1 |
| 6 | Immunomodulatory effect of bergenin and norbergenin against adjuvantinduced arthritis-A flow cytometric study 显示文摘 | Nighat Nazir Surrinder Koul Mushtaq A Qurishi | 2007 | Journal of Ethnopharmacology2007，112，2： | 1 |
| 7 | Prevalence and factors related to dental caries among pre-school children of saddar town,Karachi,Pakistan:a cross-sectional study显示文摘 | Narendar dawani Nighat nisar | | 0，，12： | 1 |
| 8 | MGMT gene silencing by promoter hypermethylation in gastric cancer in a high incidence area显示文摘 | Adfar Yousuf Mohammad Younis Bhat Arshad A. Pandith Dil Afroze Nighat P. Khan Khursheed Alam Parveen Shah M. Amin Shah Syed Mudassar | 2014 | Cellular Oncology2014，，4： | 1 |
| 9 | Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis 显示文摘 | Nighat Nazir Surrinder Koul Mushtaq Ahmad Qurishi | 2011 | European Journal of Medicinal Chemistry2011，46，6： | 1 |
| 10 | Withdrawal of inhaled corticosteroids in individuals with COPD - a systematic review and comment on trial methodology 显示文摘 | Nighat J N Stephanie JCT Sandra ME | 2011 | Respiratory Research2011，12，： | 1 |
| 11 | New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids显示文摘 | Atta-ur -Rahman Asaad Khalid Nighat Sultana M. Nabeel Ghayur M. Ahmed Mesaik M. Riaz Khan Anwar H. Gilani M. Iqbal Choudhary | 2006 | Journal of Enzyme Inhibition and Medicinal Chemistry2006，，6： | 1 |
| 12 | Triterpene and Coumarins from Skimmia Laureola显示文摘 | Nighat Sultana M. Riaz Khan M. Iqbal Choudhary | 2002 | Natural Product Research2002，，5： | 1 |
| 13 | Antioxidant and urease inhibitory C-glycosylflavonoids from Celtis africana显示文摘 | Shagufta Perveen AzzaMuhammed El-Shafae Areej Al-Taweel GhadaAhmed Fawzy Abdul Malik Nighat Afza Mehreen Latif Lubna Iqbal | 2011 | Journal of Asian Natural Products Research2011，，9： | 1 |
| 14 | Coumarin and quinoline alkaloids from Skimmia laureola显示文摘 | Sultana Nighat Afza Nighat Atta- ur- Rahman | 2004 | Science Inter- national ( Lahore Pakistan)2004，16，4： | 1 |
| 15 | Triterpene and coumarins from Skimmia laureola显示文摘 | Atta - ur - Rahman Sultana Nighat Khan M Riaz | 2002 | Natural Product Letters2002，16，5： | 1 |
| 16 | Tyrosinase inhibitor fatty ester and a quinoline alkaloid from Skimmia laureola 显示文摘 | Sultana Nighat Atta - ur - Rahman Khan Tariq H | 2005 | Zeitschrift fuer Naturforschung B : Chemical Sciences2005，60，11： | 1 |
| 17 | A convenient synthesis of 4-hydroxybenzaldehyde-carbonyl-14C 显示文摘 | Holland Herbert L Sullana nighat | 1981 | J Iabelled Compd Ra- diopharm1981，18，7： | 1 |
| 18 | Efficient regeneration and antioxidant potential in regenerated tissues of Piper nigrum L.显示文摘 | Nisar Ahmad Hina Fazal Bilal Haider Abbasi Muhammad Rashid Tariq Mahmood Nighat Fatima | 2010 | Plant Cell Tissue and Organ Culture (PCTOC)2010，，1： | 1 |
| 19 | Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis显示文摘 | Nighat Nazir Surrinder Koul Mushtaq Ahmad Qurishi Muzaffar Hussain Najar Mohammed Iqbal Zargar | 2011 | European Journal of Medicinal Chemistry2011，，6： | 1 |
| 20 | Protein glycation inhibitory activities of Lawsonia inermis and its active principles显示文摘 | Nighat Sultana Muhammed Iqbal Choudhary Ambrin Khan | 2009 | Journal of Enzyme Inhibition and Medicinal Chemistry2009，24，1： | 1 |
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