|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | Molecular overview of progressive familial intrahepatic cholestasis显示文摘Cholestasis is a clinical condition resulting from the imapairment of bile flow.This condition could be caused by defects of the hepatocytes,which are responsible for the complex process of bile formation and secretion,and/or caused by defects in the secretory machinery of cholangiocytes.Several mutations and pathways that lead to cholestasis have been described.Progressive familial intrahepatic cholestasis(PFIC)is a group of rare diseases caused by autosomal recessive mutations in the genes that encode proteins expressed mainly in the apical membrane of the hepatocytes.PFIC 1,also known as Byler’s disease,is caused by mutations of the ATP8B1 gene,which encodes the familial intrahepatic cholestasis 1 protein.PFIC 2 is characterized by the downregulation or absence of functional bile salt export pump(BSEP)expression via variations in the ABCB11 gene.Mutations of the ABCB4 gene result in lower expression of the multidrug resistance class 3 glycoprotein,leading to the third type of PFIC.Newer variations of this disease have been described.Loss of function of the tight junction protein 2 protein results in PFIC 4,while mutations of the NR1H4 gene,which encodes farnesoid X receptor,an important transcription factor for bile formation,cause PFIC 5.A recently described type of PFIC is associated with a mutation in the MYO5B gene,important for the trafficking of BSEP and hepatocyte membrane polarization.In this review,we provide a brief overview of the molecular mechanisms and clinical features associated with each type of PFIC based on peer reviewed journals published between 1993 and 2020. | Sriram Amirneni Nils Haep Mohammad A Gad Alejandro Soto-Gutierrez James E Squires Rodrigo MFlorentino | 2020 | World Journal of Gastroenterology2020，26，47： | 17 |
| 3 | Management of flexibility in projects 显示文摘 | Nils O E Olsson | 2006 | International Journal of Project Management2006，24，1： | 1 |
| 4 | Copolymerization of methyl acrylate with norbomene derivatives by atom transfer radical polymerization显示文摘 | Sharon E B Nils G Ayusman S | 2002 | Macromolecules2002，35，： | 1 |
| 5 | Critical evaluation of the Global TODS Expansion Plane显示文摘 | Donald A Enarson Nils E Billo | 2007 | Bulletin of the World Health Organization2007，85，5： | 1 |
| 6 | Magnesium:An update on physiological,clinical and analytical aspects显示文摘 | Nils E L Eero M Heikki K | 2000 | Clinica Chimica Acta2000，294，： | 1 |
| 7 | The patent asset index-a new approach to benchmark patent portfolios显示文摘 | HOLGER E NILS O | | 0，，01： | 1 |
| 8 | Group decision making in infrastructure safety planning显示文摘 | Nils Rosmullera Giampiero E G Beroggib | 2004 | Safety Science2004，42，4： | 1 |
| 9 | The Patent Asset Index--A New Approach to Benchmark Patent Portfolios 显示文摘 | Holger E Nils O | 2011 | World Patent Information2011，33，1： | 1 |
| 10 | Mathematical Modeling of Scroll Compressors - part II : overall Scroll Compressor显示文摘 | Yu Chen Nils P Halm James E Braun | 2002 | International Journal of Refrigeration2002，，25： | 1 |
| 11 | Free radical initiators as source of water - or lipid - soluble peroxyl radicals 显示文摘 | Nil E | 1990 | Methods Enzymol1990，186，： | 1 |
| 12 | Copolymerization ofmethyl acrylate with norbomene derivatives by atomtransfer radical polymerization显示文摘 | Sharon E B Nils G Ayusman S | 2002 | Macromolecules2002，35，： | 1 |
| 13 | Influence of reference points inexpost evaluations of rail infrastructure projects显示文摘 | Nils O E Olsson Hans Petter Krane AsbjφrnRolstad(a)s Mads Veiseth | | 0，，04： | 1 |
| 14 | Long-term quality of life and uncertainty in patients living with an implantable car- dioverter defibrillator显示文摘 | INGER F NILS E HANSI H | 2005 | Heart Lung2005，34，： | 1 |
| 15 | The Use of Virtual Reality for Needle-Related Procedural Pain and Distress in Children and Adolescents in a Paediatric Oncology Unit显示文摘 | Nil sson S Finnstrm B Kokinsky E | 2009 | Eur J Oncol Nurs2009，13，2： | 1 |
| 16 | Severe hypertriglyeeridemia and pancreatitis:presentation and management显示文摘 | Nils E Hardt PD Hans-Ulrich K | 2009 | Current Opin- ion in Lipidology2009，20，6： | 1 |
| 17 | Resistance to the Chemo sensitizer Verapamil in a multi - drug - resistan (MDR) human multiple myeloma cell Line 显示文摘 | Mohammad R Abbaszadegan Nils E | 1996 | Int J Cane1996，66，： | 1 |
| 18 | Group decision making in infrastructure safety planning显示文摘 | Rosmuller Nils Beroggi Giampiero E G | 2004 | ety Science2004，42，4： | 1 |
| 19 | Learning and executing generalized robot plans 显示文摘 | Richard E Fikes Peter E Hart Nils J Nilsson | 1972 | Artificial Intelligence1972，，3： | 1 |
| 20 | Bone histology of the ribs of the archaeocetes ( Mammalia: Cetacea) 显示文摘 | De BUFFRI~NIL V De RICQLI~S A RAY C E | 1990 | Journal of Vertebrate Paleontology1990，10，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员