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| 1 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 2 | Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial显示文摘AIM: To evaluate the safety and efficacy of oral administration of AlequelTM, an autologous proteincontaining colon extract.a randomized,placebo-controlled,double-blind trial.Patients were orally administered with autologous protein-containing colon extract three doses of autologous study drug per week for 15 wk,for a total of45 doses.Patients were followed for safety parameters.Remission was defined as a Crohn’s disease activity index(CDAI)score of less than or equal to 150.All patients were followed for changes in subsets of T cells by fluorescence-activated cell sorting analysis.RESULTS:Analysis was performed on a total number of evaluable patients of 14 in the study drug group and15 in the placebo group.Treatment was well tolerated by all patients.No major treatment-related adverse events were reported or observed in any of the treated patients during the feeding or follow-up periods.Between weeks 6 and 9 of the study,six of the 14(43%)evaluable subjects who received the study drug achieved a CDAI of 150 or lower.In contrast,five of the 15(33%)evaluable subjects in the placebo group achieved remission.Between weeks 9 and 12,the remission rates were 50%and 33%for the drug group and placebo group,respectively.Among the drug-treated subjects who achieved remission,the effect of the drug was judged as stable in eight of the 14 subjects as measured by at least two CDAI scores indicating remission in the 15-wk treatment period.A decreased percentage of peripheral natural killer T regulatory cells(a decrease of 28%vs an increase of 16%)and an increased ratio of CD4+/CD8+T lymphocytes(an increase of 11%vs a decrease of9%)were noted in subjects with a significant clinical response.CONCLUSION:Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease. | Eran Israeli Ehud Zigmond Gadi Lalazar Athalia Klein Nilla Hemed Eran Goldin Yaron Ilan | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 3 | Comparative analysis of rice MADS-box genes expressed during flower development显示文摘 | Nilla Pelucchi Fabio Fornara Cristina Favalli Simona Masiero Clara Lago Enrico M. Pè Lucia Colombo Martin M. Kater | 2002 | Sexual Plant Reproduction2002，，3： | 1 |
| 4 | The rice StMADSll-like genes OsMADS22 and OsMADS47 cause floral reversions in Arabidopsis without complementing the svp and ag124 mutants 显示文摘 | FABIO FORNARA VERONICA GREGIS NILLA PELUCCHI | 2008 | J Exp Bot2008，59，： | 1 |
| 5 | Treatment of Chronic Hepatitis C Virus Infection via Antioxidants: Results of a Phase I Clinical Trial显示文摘 | Alla Melhem Mirela Stern Oren Shibolet Eran Israeli Zvi Ackerman Orit Pappo Nilla Hemed Mina Rowe Hana Ohana George Zabrecky Robert Cohen Yaron Ilan | 2005 | Journal of Clinical Gastroenterology2005，，8： | 1 |
| 6 | Children of divoreein the 1990s :A meta-analysis显示文摘 | REIFMAN A NILLA L C AMAAS J A | 2003 | Journal of Divorce and Remarriage2003，36，： | 1 |
| 7 | Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis 显示文摘 | Nillas S Michael P J Jennifer L O | 2011 | Pain2011，152，： | 1 |
| 8 | Age-associated changes in hearts of male Fischer 344/Brown Norway F1 rats 显示文摘 | Walker EM Jr Nillas MS Mangiarua EI | 2006 | Ann Clin Lab Sci2006，36，4： | 1 |
| 9 | Manganese toxicity:free amino acids in the striatum and olfactory bulb of the mouse显示文摘 | nilla E Arrieta A Castro F | 1994 | Invest Clin1994，35，： | 1 |
| 10 | Role of motility and chemotaxis in the pathogenesis of Dickeya dadantii 3937 (ex Erwinia chrysanthemi 3937) 显示文摘 | Antunez-Lamas M Cabrera-Ordonez E Lopez-Sola- nilla E | 2009 | Microbiology2009，155，2： | 1 |
| 11 | Age-associated changes in hearts of male Fischer 344/Brown Norway F1 rats 显示文摘 | Walker EM Jr Nillas MS Mangiarua EI | 2006 | Ann Clin Lab Sci2006，36，4： | 1 |
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