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| 1 | Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients显示文摘AIM To investigate the prospective importance of serum micro(mi)RNAs(mi R-125 b, mi R-138 b, mi R-1269, mi R-214-5p, mi R-494, mi R375 and mi R-145) as early biomarkers for the diagnosis of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS Two-hundred and fifty HCV4 a patients, 224 HCV4 aHCC patients, and 84 healthy controls were enrolled in the study. Expression levels of mi R214-5p, mi R-125 b, mi R-1269 and mi R-375 were quantified using quantitative real-time PCR.RESULTS Expression of the selected mi RNAs in serum wassignificantly lower in HCC patients than in the healthy controls, except for mi R-1269 and mi R-494. There was a significant difference between HCC and HCV patients, in particular for HCC and late stage fibrosis, rather than HCV patients and early fibrosis. It is obvious that mi R-1269 was significantly upregulated in HCC cases compared to hepatic fibrosis cases. Each mi RNA can show HCC progression. Multivariate logistic regression analysis indicated that the tested panel of mi RNAs(mi R214-5p, mi R-125 b, mi R-1269 and mi R-375) represent accurate and specific indictors of HCC development.CONCLUSION This study presents a panel of mi RNAs with strong power as putative diagnostic and prognostic biomarkers for HCV-induced HCC. Moreover, mi R-214-5p and mi R-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to HCC. | Moustafa Nouh Elemeery Ahmed Noah Badr Marwa Anwar Mohamed Doaa Ahmed Ghareeb | 2017 | World Journal of Gastroenterology2017，23，21： | 20 |
| 2 | Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals显示文摘线粒体为精力新陈代谢和反应的氧种类(ROS ) 的生产是必要的。在未经触动的房间,呼吸线粒体展览自发的 “ superoxide flashes”,对短暂 mitochondrial 渗透转变(tMPT ) 结果的 quantal 生产 ROS 事件。这里,我们在表示 superoxide 生物传感器 mt-cpYFP 的生活老鼠在 mitochondrial superoxide 闪光和 tMPT 活动的 vivo 成像执行第一,并且表明他们联合到整个身体的葡萄糖新陈代谢。柔韧的 tMPT/superoxide 闪光活动发生在骨胳的肌肉和 anesthetized 的臀部的神经转基因的老鼠。在骨胳的肌肉,成像 tMPT/superoxide 闪光揭示了线粒体的迷宫的三维的网络同时地操作。tMPT/superoxide 闪光活动响应全身的葡萄糖挑战或胰岛素刺激澎湃,以一种显然调制频率的方式并且也在 tMPT 的 gating 模式包含移动。因此,在 tMPT 依赖的 mitochondrial ROS 的 vivo 成像,信号和 metabolism-tMPT-superoxide 的发现闪光联合标记为 mitochondrial 功能并且 ROS 处于健康和疾病发信号的学习的重要工艺、概念的进展。 | Huaqiang Fang Min Chen Yi Ding Wei Shang Jiejia Xu Xing Zhang Wanrui Zhang Kaitao Li Yao Xiao Feng Gao Shujiang Shang Jing-Chao Li Xiao-Li Tian Shi-Qiang Wang Jingsong Zhou Noah Weisleder Jianjie Ma Kunfu Ouyang Ju Chen Xianhua Wang Ming Zheng Wang Wang Xiuqin Zhang Heping Cheng | 2011 | Cell Research2011，21，9： | 11 |
| 3 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 4 | Peptide-based targeting of immunosuppressive cells in cancer显示文摘Cancer progression is marked by the infiltration of immunosuppressive cells,such as tumor-associated macrophages(TAMs),regulatory T lymphocytes(Tregs),and myeloid-derived suppressor cells(MDSCs).These cells play a key role in abrogating the cytotoxic T lymphocyte-mediated(CTL)immune response,allowing tumor growth to proceed unabated.Furthermore,targeting these immunosuppressive cells through the use of peptides and peptide-based nanomedicine has shown promising results.Here we review the origins and functions of immunosuppressive cells in cancer progression,peptide-based systems used in their targeting,and explore future avenues of research regarding cancer immunotherapy.The success of these studies demonstrates the importance of the tumor immune microenvironment in the propagation of cancer and the potential of peptide-based nanomaterials as immunomodulatory agents. | Noah T.Trac Eun Ji Chung | 2020 | Bioactive Materials2020，5，1： | 7 |
| 5 | Sodium lanthanide fluoride core-shell nanocrystals: A general perspective on epitaxial shell growth显示文摘理解结构的特征和生长机制为与特殊性质产生核心壳 nano-heterostructures 是必要的。特别在基于 lanthanide 的 nanocrystals,核心壳作文的合理设计能被利用提高 / 调节最后的 nanostructure 的光性质,或能被用来集成多重功能的应用程序(例如,光 / 磁性) 。在这篇文章,我们在钠 lanthanide 在我们取向附生的壳生长的当前的理解考察进步氟化物(NaLnF4 ) nanocrystals。以便理解取向附生的壳生长核心 nanocrystals 不得不一致,并且标明日期高质量的近一致的尺寸 / 形状分散的合成基于 lanthanide 的 nanocrystals 的控制合成主要与 nanocrystals 的这个班被完成了。在在 nanocrystals (NaLnF4 ) 的这个班上的核心壳合成和取向附生的壳生长机制的进步被考察,并且一个一般观点基于不同描述技术在核心壳形态学上被提供。当在在各种各样的功能的应用程序学习核心壳结构的影响有巨大的进步时,在我们看来,这评论也加亮控制核心壳形态学的方法的仍然有限的理解,它强调尚待被探讨最大化他们的性能的一些重要、未答复的问题。 | Noah J. J. Johnson Frank C. J. M. van Veggel | 2013 | Nano Research2013，6，8： | 5 |
| 6 | Easy removing of phenol from wastewater using vegetable oil-based organic solvent in emulsion liquid membrane process显示文摘Phenol is considered as pollutant due to its toxicity and carcinogenic effect.Thus,variety of innovative methods for separation and recovery of phenolic compounds is developed in order to remove the unwanted phenol from wastewater and obtain valuable phenolic compound.One of potential method is extraction using green based liquid organic solvent.Therefore,the feasibility of using palm oil was investigated.In this research,palm oil based organic phase was used as diluents to treat a simulated wastewater containing 300×10^(-6) of phenol solution using emulsion liquid membrane process(ELM).The stability of water-in-oil(W/O) emulsion on diluent composition and the parameters affecting the phenol removal efficiency and stability of the emulsion;such as emulsification speed,emulsification time,agitation speed,surfactant concentration,pH of external phase,contact time,stripping agent concentration and treat ratio were carried out.The results of ELM study showed that at ratio7 to 3 of palm oil to kerosene,5 min and 1300 r·min^(-1) of emulsification process the stabile primary emulsion were formed.Also,no carrier is needed to facilitate the phenol extraction.In experimental conditions of500 r·min^(-1) of agitation speed,3%Span 80,pH 8 of external phase,5 min of contact time,0.1 mol·L^(-1) NaOH as stripping agent and 1:10 of treat ratio,the ELM process was very promising for removing the phenol from the wastewater.The extraction performance at about 83%of phenol was removed for simulated wastewater and an enrichment of phenol in recovery phase as phenolate compound was around 11 times. | Norasikin Othman Norul Fatiha Mohamed Noah Lim Yin Shu Zing-Yi Ooi Norela Jusoh Mariani Idroas Masahiro Goto | 2017 | Chinese Journal of Chemical Engineering2017，25，1： | 4 |
| 7 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 8 | Photo tourism显示文摘 | Noah Snavely Steven M. Seitz Richard Szeliski | 2006 | ACM Transactions on Graphics (TOG)2006，，3： | 3 |
| 9 | MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes显示文摘BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(T2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among T2DM patients is important to reduce the morbidity and mortality of this disease.MicroRNA(miRNA)is considered a key player in HCC and T2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic tool.AIM To investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic patients.METHODS Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,RT-qPCR was used to validate significantly altered miRNAs between the two groups.Candidate miRNAs were tested in serum samples of 200 T2DM patients,270 LC patients,200 HCC patients,and 225 healthy control subjects.Additionally,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+T2DM).RESULTS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive T2DM patients.Two miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC patients.Analysis of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic patients.The study recommends further research to shed light on a possible role of c-Met in T2DM-associated HCC via the miRNA regulatory pathway. | Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa Ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa Ahmed Noah Badr Doaa Ahmed Ghareeb Cheol-Ho Pan | 2019 | World Journal of Gastroenterology2019，25，42： | 3 |
| 10 | Update on novel endoscopic therapies to treat gastroesophageal reflux disease: A review显示文摘Endoscopic treatments for gastroesophageal reflux disease(GERD) have become increasingly popular in recent years. While surgical intervention with the Laparoscopic Nissen Fundoplication remains the gold standard, two endoscopic interventions, specifically, are gaining traction in clinical use(Esophy X and Stretta). The Esophy X(Endo Gastric Solutions, Inc., Redmond, WA, United States) was developed as a method of restoring the valve at the GE junction through an endoluminal fundoplication(ELF) technique. Long-term data suggests that transoral incisional fundoplication(TIF) with Esophy X may be effective for symptom control and proton pump inhibitor reduction or cessation for up to 2-6 years. There is no evidence that Esophy X is more effective than surgical intervention. TIF may be most effective for patients with HH < 2 cm and Hill Grade I/II valves. Stretta(Mederi Therapeutics, Greenwich, CT, United States) was approved by the Food and Drug Administration in 2000. It delivers radiofrequency energy to the lower esophageal sphincter and gastric cardia. Published reviews of the literature are conflicted in their recommendations of Stretta in the management of GERD. The literature suggests that the Stretta procedure has an acceptable safety profile and may be effective in reducing symptom burden and quality of life scores up to 8 years post-intervention. However, there does not appear to be any sustained improvement in objective outcomes and there is no evidence that Stretta results in improved outcomes as compared to surgical intervention. Treatment modalities for GERD, as a field, suffer from a lack of standardization in primary and secondary outcomes. Although many studies have looked at health related quality of life, the tools used to do so are markedly heterogeneous. Future directions for the endoscopic treatment of GERD include novel techniques like endoscopic submucosal dissection. | Jessica Hopkins Noah J Switzer Shahzeer Karmali | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，11： | 2 |
| 11 | Narrowing the phase window width in prospectively ECG-gated single heart beat 320-detector row coronary CT angiography显示文摘 | Michael L. Steigner Hansel J. Otero Tianxi Cai Dimitrios Mitsouras Leelakrishna Nallamshetty Amanda G. Whitmore Hale Ersoy Noah A. Levit Marcelo F. Di Carli Frank J. Rybicki | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 2 |
| 12 | Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review显示文摘 | Soni C. Chawla Noah Federman Di Zhang Kristen Nagata Soujanya Nuthakki Michael McNitt-Gray M. Ines Boechat | 2010 | Pediatric Radiology2010，，： | 2 |
| 13 | The COVID-19 pandemic and physical activity显示文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article. | Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji | 2020 | Sports Medicine and Health Science2020，2，2： | 2 |
| 14 | Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure显示文摘 | Noah J. Marcus Rodrigo Rio Evan P. Schultz Xiao‐Hong Xia Harold D. Schultz | 2014 | The Journal of Physiology2014，，： | 2 |
| 15 | The spatiotemporal form of urban growth: measurement, analysis and modeling显示文摘 | Martin Herold Noah C. Goldstein Keith C. Clarke | 2003 | Remote Sensing of Environment2003，，3： | 2 |
| 16 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 17 | Superconductivity in antiperovskites显示文摘We present a comprehensive theoretical study of conventional superconductivity in cubic antiperovskites materials with composition XYZ_(3) where X and Z are metals,and Y is H,B,C,N,O,and P.Our starting point are electron–phonon calculations for 397 materials performed with density-functional perturbation theory.While 43%of the materials are dynamically unstable,we discovered 16 compounds close to thermodynamic stability and with T_(c) higher than 5 K.Using these results to train interpretable machine-learning models,leads us to predict a further 57(thermodynamically unstable)materials with superconducting transition temperatures above 5 K,reaching a maximum of 17.8 K for PtHBe3.Furthermore,the models give us an understanding of the mechanism of superconductivity in antiperovskites.The combination of traditional approaches with interpretable machine learning turns out to be a very efficient methodology to study and systematize whole classes of materials and is easily extendable to other families of compounds or physical properties. | Noah Hoffmann Tiago F.T.Cerqueira Jonathan Schmidt Miguel A.L.Marques | 2022 | npj Computational Materials2022，，1： | 2 |
| 18 | Copolymerization of peptide derived monomers and methyl methacrylate 显示文摘 | Birchall A C Bush S M Noah M | 2001 | Polymer2001，42，： | 1 |
| 19 | Dynamic T1- weighted ,magnetic resonance imaging and positron emission tomography in patients with lung cancer: Correlating vscular physiology with glucose metabolism显示文摘 | George JH Leena MH Noah C | 1998 | Clinical Cancer Research1998，4，： | 1 |
| 20 | Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus显示文摘 | Noah TL Becker S | 2000 | Clin Immunol2000，97，1： | 1 |
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