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| 1 | Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study显示文摘AIM To assess the relationship between serum levels of insulin-like growth factor-1(IGF1)/IGF-binding protein-3(IGFBP3)and the risk of esophageal carcinoma.METHODS We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective,nested case-control study of participants from the Japan Collaborative Cohort Study.A baseline survey was conducted from 1988 to 1990.Of the 110585 enrolled participants,35%donated blood samples.Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies.A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.RESULTS Thirty-one cases and 86 controls were eligible for the present assessment.The molar ratio of IGF1/IGFBP3,which represents the free and active form of IGF1,was not correlated with the risk of esophageal carcinoma.A higher molar difference between IGFBP3and IGF1,which estimates the free form of IGFBP3,was associated with a decreased risk of esophageal carcinoma(P=0.0146),and people in the highest tertile had the lowest risk(OR=0.107,95%CI:0.017-0.669).After adjustment for body mass index,tobacco use,and alcohol intake,the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma(P=0.0150).CONCLUSION The free form of IGFBP3,which is estimated by this molar difference,may be inversely associated with esophageal cancer incidence. | Yasushi Adachi Masanori Nojima Mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi | 2017 | World Journal of Gastroenterology2017，23，19： | 4 |
| 2 | Distributed Flow Shop Scheduling with Sequence-Dependent Setup Times Using an Improved Iterated Greedy Algorithm显示文摘To meet the multi-cooperation production demand of enterprises,the distributed permutation flow shop scheduling problem(DPFSP)has become the frontier research in the field of manufacturing systems.In this paper,we investigate the DPFSP by minimizing a makespan criterion under the constraint of sequence-dependent setup times.To solve DPFSPs,significant developments of some metaheuristic algorithms are necessary.In this context,a simple and effective improved iterated greedy(NIG)algorithm is proposed to minimize makespan in DPFSPs.According to the features of DPFSPs,a two-stage local search based on single job swapping and job block swapping within the key factory is designed in the proposed algorithm.We compare the proposed algorithm with state-of-the-art algorithms,including the iterative greedy algorithm(2019),iterative greedy proposed by Ruiz and Pan(2019),discrete differential evolution algorithm(2018),discrete artificial bee colony(2018),and artificial chemical reaction optimization(2017).Simulation results show that NIG outperforms the compared algorithms. | Xue Han Yuyan Han Qingda Chen Junqing Li Hongyan Sang Yiping Liu Quanke Pan Yusuke Nojima | 2021 | Complex System Modeling and Simulation2021，1，3： | 4 |
| 3 | High Th1/Th2 ratio in patients with multiple myeloma显示文摘 | Hatsue Ogawara Hiroshi Handa Tohru Yamazaki Takuma Toda Kensuke Yoshida Natsumi Nishimoto Wedad Hamdi Saleh Al-ma’Quol Yoriaki Kaneko Takafumi Matsushima Norifumi Tsukamoto Yoshihisa Nojima Morio Matsumoto Morio Sawamura Hirokazu Murakami | 2004 | Leukemia Research2004，，2： | 3 |
| 4 | Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis显示文摘We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type. | Motoko Sasaki Ichiro Araki Toshiaki Yasui Masaru Kinoshita Keita Itatsu Takayuki Nojima Yasuni Nakanuma | 2009 | World Journal of Gastroenterology2009，15，5： | 3 |
| 5 | Laparoscopic-extracorporeal surgery performed with a fixation device for adnexal masses complicating pregnancy: Report of two cases显示文摘The potential complications associated with an adnexal mass discovered during early pregnancy call for surgical treatment. Ideally, surgery is performed after gestational week 12, but uterine expansion after the first trimester makes surgery difficult. We report two pregnancies complicated by adnexal masses for which we used an organ fixation device for safe performance of single-site umbilical laparoscopic surgery. Pelvic magnetic resonance imaging depicted a dichorionic, diamniotic twin pregnancy and 60-mm right adnexal mass in the first patient and bilateral adnexae in the second. All three masses were suspected mature cystic teratomas. Both patients underwent laparoscopic surgery during gestational week 14. With use of an organ fixation device, traction was applied until the mass reached the umbilicus; tumor resection was performed extracorporeally. In the second patient, the second mass was simply aspirated because adhesions were encountered. Our single-site laparoscopicextracorporeal technique proved to be a safe approach to an otherwise high-risk situation. | Hanako Kasahara Iwaho Kikuchi Aya Otsuka Yoko Tsuzuki Michio Nojima Koyo Yoshida | 2017 | World Journal of Methodology2017，7，4： | 3 |
| 6 | Heparin bridge therapy and post-polypectomy bleeding显示文摘AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants. | Toshiyuki Kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura Masanori Nojima Hiroshi Nakase | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 7 | Realtime PD identification in diagnosis of gis using symmetric and asymmetric UHF sensors显示文摘 | Toshihiro Hoshino Kenichi Nojima Masahiro Hanai | 2004 | IEEE Trans on Power Delivery2004，19，3： | 1 |
| 8 | Gt and S-phase checkpoints, chromosome instability and cancer 显示文摘 | Nojima H | 2004 | Methods Mol Biol2004，280，1： | 1 |
| 9 | Osteosarcoma Resembling Osteoblastoma AndIts Heterotransplantation Into Nude Mice显示文摘 | Nojima T Yamaaguchi H Nagashima K | 1992 | Acta Pathol Japn1992，42，： | 1 |
| 10 | Genome-wide expression changes in Saccharomyces cerevisiae in response to high-LET ionizing radiation显示文摘 | Mizukami-Murata S Iwahashi H Kimura S Nojima K Sakurai Y Saitou T | 2010 | Appl Biochem Biotechnol2010，162，3： | 1 |
| 11 | Very fast transients in 1 000 kV gas insulated switchgear 显示文摘 | Yamagata Y Nakada Y Nojima K | 1999 | 1EEE Power Engineering Society Transmission and Distribution Conference1999，，5： | 1 |
| 12 | Science显示文摘 | Nojima S Schal C Webster F X Santangelo R G Roelofs W L | 2005 | 307:11042005，307，： | 1 |
| 13 | Antimicrobial susceptibility by Etest of Bartonella henselae isolated from cats and human in Japan显示文摘 | Tsuneoka H Yanagihara M Nojima J | 2010 | J Infect Chemother2010，16，6： | 1 |
| 14 | High efficiency transformation of Escherichia coli with plasmids显示文摘 | Inoue H Nojima H Okayama H | 1990 | Gene1990，96，1： | 1 |
| 15 | Histone deacetylase 1 regulates retinal neurogene- sis in zebrafish by suppressing Wnt and Notch signaling path- ways 显示文摘 | Yamaguctd M Tonou-Fujimori N Komori A Maeda R Nojima Y IA H | 2005 | Development2005，132，13： | 1 |
| 16 | Discovery of immu- nostimulatory CpG-DNA and its application to tuberculosis vaccine development显示文摘 | Yamamoto S Yamamoto T Nojima Y | 2002 | Jpn J Infect Dis2002，55，2： | 1 |
| 17 | Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells显示文摘 | Takayuki Nojima Fumitaka Nakamura Masatsugu Ishikura Kazuaki Inoue Kazuo Nagashima Hiroyuki Kato | 1993 | International Journal of Pancreatology1993，，3： | 1 |
| 18 | Involvement of renal progenitor tubular cells in epithelial-to-mesenchymal transition in fibrotic rat kidneys显示文摘 | Yamashita S Maeshima A Nojima Y | 2005 | J Am Soc Nephrol2005，16，7： | 1 |
| 19 | Investigation of responders and non-responders to long-term donepezil treatment显示文摘 | Inoue J Hoshino R Nojima H | 2010 | Psychogeriatrics2010，10，： | 1 |
| 20 | An electrochemical double-layer capacitor using an activated carbon electrode with gel electrolyte binder显示文摘 | Osaka T Liu X Nojima M | 1999 | J Electrochem Soc1999，146，5： | 1 |
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