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| 1 | Analysis of aerodynamic and thermodynamic parameters on the grassy marshland surface of Tibetan Plateau | TSUKAMOTO Osamu ISHIKAWA Hirohiko TAMAGAWA Ichiro | 2002 | Progress in Natural Science:Materials International2002，12，1： | 34 |
| 2 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 3 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 4 | 据于矢耳石Sr/Ca值的长江日本鳗鲡迁移格局多样性分析(英文)显示文摘长江口是中国日本鳗鳗苗的主要产区和仅存的成鳗渔业水域。日本鳗自长江河口至上游金沙江近3000km干流及许多支流中都有分布,但其迁移行为却不为人了解。该文分析了2008年9~11月采自长江靖江段(31o30′N,120o42′E)的153尾银色鳗样本的生物学特征,测定了其中27尾标本的矢耳石Sr/Ca值。结果显示,153尾样本中有雌性85尾、雄性68尾,雌雄性比1:0.8。雌性由3~7(平均5.52)龄组成,平均体长(669±80)mm,体重(555±229)g,丰满度1.77±0.22,性腺指数(GSI)1.32±0.31。雄性由3~5(平均4.38)龄组成,平均体长(518±51)mm,体重(234±76)g,丰满度1.62±0.18,GSI0.21±0.11。雌性的这些生物学参数均显著大于雄性(P<0.05)。依据矢耳石线鳗标志轮平均Sr/Ca值(7.99±1.05)×10-3进行判断,有17尾(即62.96%个体)为'淡水型',10尾(即37.04%个体)为'河口型'。16尾雌性中有13尾(即81.25%)为'淡水型',3尾为'河口型'。11尾雄性中仅36.36%为'淡水型',63.64%为'河口型'。对每个生长层组的Sr/Ca值分析表明,雌雄间2龄时无显著差异,但3龄、4龄和洄游龄组都有显著或极显著的差异,预示着2龄时两者的栖息水域比较一致,但后来出现了明显栖息地分化。 | 郭弘艺 郑怡 唐文乔 沈皓 魏凯 谢正丽 Katsumi Tsukamoto | 2011 | Zoological Research2011，32，4： | 10 |
| 5 | 直肠癌直肠系膜切除术联合或者不联合侧方淋巴结清扫的随机试验长期随访(JCOG 0212)显示文摘背景:日本临床肿瘤学组(Japanese Clinical Oncology Group,JCOG)0212(ClinicalTrials.gov NCT00190541)试验是一个关于无侧方淋巴结肿大的Ⅱ~Ⅲ期直肠癌的Ⅲ期非劣效性临床试验。该试验比较了单纯直肠系膜切除术(mesorec⁃tal excision,ME)和ME联合侧方淋巴结清扫术(lateral lymph node dissection,LLND)的效果,其主要终点是无复发生存率(RFS),5年初步结果分析未能证实单纯ME非劣效于ME联合LLND。本研究的目的是通过JCOG 0212的长期随访数据来分析单纯ME是否非劣效于ME联合LLND。 | 梁逸超 TSUKAMOTO S FUJITA S OTA M | 2020 | 结直肠肛门外科2020，26，3： | 9 |
| 6 | Remote sensing parameterization of the processes of energy and water cycle over desertification areas显示文摘In order to understand the processes of land surface-atmosphere interaction over de-sertification area, it is indispensable to utilize of satellite remote sensing. Two scenes of LandsatTM were used to produce a set of maps of surface reflectance, MSAVI, vegetation coverage, sur-face temperature, net radiation, soil heat flux, sensible heat flux and latent heat flux. Statisticalanalysis based on these maps revealed some quantitative significant land surface characteristics.Future developments of the method are also discussed. | 马耀明 Tsukamoto Osamu Ishikawa Hirohiko | 2002 | Science China Earth Sciences2002，45，z1： | 9 |
| 7 | Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma显示文摘Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated patients.Gastrectomy with lymph node dissection followed by chemotherapy is the treatment of choice.Regimens used for gastric adenocarcinoma are usually selected.However,median survival remains less than six months.In this case report,we describe a case of primary gastric choriocarcinoma with a clinical complete response to multidisciplinary treatment including surgery,chemotherapy,and radiofrequency ablation(RFA).The patient was originally referred for general malaise.Esophagogastroduodenoscopy demonstrated a large tumor occupying the fornix,and total gastrectomy with lymph node dissection was performed.Seven days later,multiple liver metastatic recurrences with high serum levels of beta-human chorionic gonadotropin(β-hCG) were recognized.Chemotherapy with a gonadal choriocarcinoma regimen consisting of etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA/CO),was initiated.After three cycles,serum β-hCG decreased markedly and the tumors disappeared.Six months later,multiple lung metastatic recurrences were found.After one cycle of EMA/CO,only one nodule remained.Computed tomography-guided RFA was performed for this oligometastatic tumor.The patient has been alive with no evidence of disease for 10 years after the initial diagnosis.To the best of our knowledge,this patient with recurrent primary gastric choriocarcinoma has achieved the longest survival.The present case is the first report of choriocarcinoma metastatic to the lung successfully treated with RFA.From our retrospective analysis of recurrent or unresectable primary gastric choriocarcinoma,we propose that gonadal choriocarcinoma regimens can be considered as first-line for primary gastric choriocarcinoma. | Kazuhiro Takahashi Shigeki Tsukamoto Ken Saito Nobuhiro Ohkohchi Katsu Hirayama | 2013 | World Journal of Gastroenterology2013，19，31： | 6 |
| 8 | Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese显示文摘AIM: To examine an association between the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis (UC) and Crohn's disease (CD) in the Japanese.METHODS: We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms (SNPs)in CTLA4, such as C-318T in the promoter region, A+49G in exon 1 and G+6230A in the 3' untranslated region (3'-UTR) by a PCR-restriction fragment length polymorphism method, and to an (AT)n repeat polymorphism in 3'-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using χ2 and Fisher exact tests.RESULTS: The frequency of 'A/A' genotype at the G+6230A SNP site was statistically lower in UC patients than in controls (3.7% vs 11.0%, P= 0.047, odds ratio (OR) = 0.311). Moreover, the frequency of'G/G' genotype at the A+49G SNP site was significantly higher in CD patients with fistula (48.6%) than those without it (26.2%)(P = 0.0388, OR=2.67).CONCLUSION: The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese. | Haruhisa Machida Kazuhiro Tsukamoto Chun-Yang Wen Yukiko Narumi Saburou Shikuwa Hajime Isomoto Fuminao Takeshima Yohei Mizuta Norio Niikawa Ikuo Murata Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，27： | 4 |
| 9 | Comparison of percutaneous radiofrequency ablation and CyberKnife®for initial solitary hepatocellular carcinoma:A pilot study显示文摘AIM To compare therapeutic outcomes and adverseevents in initial solitary hepatocellular carcinoma(HCC) treated with radiofrequency ablation (RFA) andCyberKnife?.METHODS: Seventy three consecutive patients withinitial solitary HCC treated with RFA (38 patients;RFA group) and CyberKnife (35 patients; CK group)were enrolled in this study. Background factorswere compared between the two groups. Local andintrahepatic distant recurrence control, and cumulativesurvival rates were compared between the two groups.These were determined using the Kaplan-Meier method,and the significance of differences was analyzed by log-rank test. The presence of more grade 3 on CTCAE ver.4.0 early and late adverse events was investigated.RESULTS: In background factors, age was significantlyhigher (P = 0.005) and the tumor diameter wassignificantly larger (P = 0.001) in the CK group. The1-year local recurrence control rates were 97.4%and 97.1% in the RFA and CK groups, respectively (P= 0.71); the 1-year intrahepatic distant recurrencecontrol rates were 85.6% and 86.1%, respectively (P= 0.91); and the 1-year cumulative survival rates were100% and 95.2%, respectively (P = 0.075), showingno significant difference in any rate between the twogroups. There were no late adverse event in the RFAgroup, but 11.4% in the CK group had late adverseevents. In the CK group, the Child-Pugh score at 12 moafter treatment was significantly higher than that in theRFA group (P = 0.003) and significantly higher than thescore before treatment (P = 0.034).CONCLUSION: The occurrence of adverse events is aconcern, but CyberKnife treatment is likely to becomean important option for local treatment of early HCC. | Kazue Shiozawa Manabu Watanabe Takashi Ikehara Yasushi Matsukiyo Michio Kogame Yui Kishimoto Yusuke Okubo Hiroyuki Makino Nobuhiro Tsukamoto Yoshinori Igarashi Yasukiyo Sumino | 2015 | World Journal of Gastroenterology2015，21，48： | 4 |
| 10 | Effect of heparin on high glucose induced proliferation and expression of matrix metalloproteinases in normal human mesangial cells显示文摘Background The pathogenesis of diabetic nephropathy (DN) is a complex pathophysiological process.Its precise mechanism is not fully known. In recent years it has been recognized that synthesis of various extracelluar matrix (ECM) components may increase, and that degradation of ECM may decrease in DN. It was reported heparin could inhibit mesangial cells proliferation in vitro. The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells. Methods The medium contained either low glucose (5 mmol/L) or high glucose (25 mmol/L). The concentrations of heparin in the culture medium were 0, 25, 50,100, 200 or 400 μg/mL. A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells. Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium. They showed a 1.93 fold expansion after 72 h in high glucose in contrast to a 1.63 fold expansion in low glucose. In the presence of heparin, mesangial cells proliferation was inhibited, which was more obvious at high glucose concentrations than at low glucose concentrations. In high glucose, with heparin concentration of 50, 100, 200 and 400 μg/mL, the mesangial cells showed a 0. 61 fold, 0.52 fold, 0.52 fold and 0.41 fold reductions in cell number compared to cells grown without heparin. In low glucose, only concentrations of 200 μg/mL and 400 μg/mL showed reduction in cell number, namely 0.54 fold and 0.45 fold, when compared to cells grown without heparin. In Western blot analysis,MMP1, MMP2, MMP3 and MMP9 was expressed by mesangial cells expressed in both high and low glucose concentrations, which was more prominent in high glucose medium. Incubation of heparin further increased expression of MMP1, MMP2, MMP3 and MMP9. Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations. Higher glucose concentrations led to increased MMP expression, which may take part in the regulation of mesangial matrix synthesis and degradation. Addition of heparin resulted in a corresponding increase in MMP expression, most notably at high glucose concentrations, indicating a potentially renoprotective role in DN. | ZHOU Qiao-ling Yasumoto Yuichiro Tsukamoto Masatoshi Nozaki Tsuyoshi Sogabe Atsushi Harada Kouji ZHANG Yi-xiang LIN Xiao-yan ZHANG Yang-de Arima Terukatsu | 2005 | Journal of Central South University of Technology2005，12，z1： | 3 |
| 11 | Dual-shot dynamics and ultimate frequency of all-optical magnetic recording on GdFeCo显示文摘Although photonics presents the fastest and most energy-efficient method of data transfer,magnetism still offers the cheapest and most natural way to store data.The ultrafast and energy-efficient optical control of magnetism is presently a missing technological link that prevents us from reaching the next evolution in information processing.The discovery of all-optical magnetization reversal in GdFeCo with the help of 100fs laser pulses has further aroused intense interest in this compelling problem.Although the applicability of this approach to high-speed data processing depends vitally on the maximum repetition rate of the switching,the latter remains virtually unknown.Here we experimentally unveil the ultimate frequency of repetitive all-optical magnetization reversal through time-resolved studies of the dual-shot magnetization dynamics in Gd27 Fe63.87 C09.T3.Varying the intensities of the shots and the shotto-shot separation,we reveal the conditions for ultrafast writing and the fastest possible restoration of magnetic bits.It is shown that although magnetic writing launched by the first shot is completed after 100 ps,a reliable rewriting of the bit by the second shot requires separating the shots by at least 300 ps.Using two shots partially overlapping in space and minimally separated by 300 ps,we demonstrate an approach for GHz magnetic writing that can be scaled down to sizes below the diffraction limit. | Sicong Wang Chen Wei\Yuanhua Feng Hongkun Cao Wenzhe Li Yaoyu Cao Bai-Ou Guan Arata Tsukamoto Andrei Kirilyuk Alexey VKimel Xiangping Li | 2021 | Light(Science & Applications)2021，10，1： | 3 |
| 12 | High Th1/Th2 ratio in patients with multiple myeloma显示文摘 | Hatsue Ogawara Hiroshi Handa Tohru Yamazaki Takuma Toda Kensuke Yoshida Natsumi Nishimoto Wedad Hamdi Saleh Al-ma’Quol Yoriaki Kaneko Takafumi Matsushima Norifumi Tsukamoto Yoshihisa Nojima Morio Matsumoto Morio Sawamura Hirokazu Murakami | 2004 | Leukemia Research2004，，2： | 3 |
| 13 | Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene显示文摘AIM: To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5′-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD).METHODS: Frequencies and distributions of NAT2 and UGT1A7SNPs as well as their haplotypes were investigated in 95 patients with UC, 60 patients with CD, and 200gender-matched, unrelated, healthy, control volunteers by PCR-restriction fragment length polymorphism (RFLP),PCR-denaturing high-performance liquid chromatography (DHPLC), and direct DNA sequencing.RESULTS: Multiple logistic regression analysis revealed that the frequency of haplotype, NAT2*7B, significantly increased in CD patients, compared to that in controls (P= 0.0130, OR = 2.802, 95%CI = 1.243-6.316). However,there was no association between NAT2 haplotypes and UC, or between any UGT1A7haplotypes and inflammatory bowel disease (IBD).CONCLUSION: It is likely that the NAT2 gene is one of the determinants for CD in Japanese. Alternatively, a new CD determinant may exist in the 8p22 region, whereNAT2is located. | Haruhisa Machida Kazuhiro Tsukamoto Chun-Yang Wen Saburou Shikuwa Hajime Isomoto Yohei Mizuta Fuminao Takeshima Kunihiko Murase Naomichi Matsumoto Ikuo Murata Shigeru Kohno Chen-Yang Wen | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 14 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 15 | A Real-coded Genetic Algorithm Applied to Optimum Design of a Low Solidity Vaned Diffuser for Diffuser Pinup显示文摘A numerical procedure for hydrodynamic redesign of the conventional vaned diffuser into the low solidity vaned diffuser by means of a real-coded genetic algorithm with Boltzmann, Tournament and Roulette Wheel selection is presented. In the first part, an investigation on the relative efficiency of the different real-coded genetic algorithm is carried out on a typical mathematical test function. The real-coded genetic algorithm with Boltzmann selection shows the best optimization performance compared to the Tournament and Roulette Wheel selection. In the second part, an approach to redesign the vaned diffuser profile is introduced. Goal of the optimum design is to search the highest static pressure recovery coefficient and low solidity vaned diffuser. The result of the low solidity vaned diffuser optimum design confirms that the efficiency and optimization performance of the real-coded Boltzmann selection genetic algorithm outperforms the other selection methods. A comparison between the designed low solidity vaned diffuser and original vaned diffuser shows that the diffuser pump with the redesigned low solidity vaned diffuser has the higher static pressure recovery and improved total hydrodynamic performance. In addition, the smaller outlet diameter of designed vaned diffuser tends to a more compact size of diffuser pump compared to the original diffuser pump. The obtained results also demonstrate the real-coded Boltzmann selection genetic algorithm is a promising optimization algorithm for centrifugal pumps design. | Jun LI Hiroshi TSUKAMOTO Fluid Engineering Laboratory, Department of Mechanical Engineering, Kyushu Institute of Technology Kitakyushu 804-8550, JAPAN | 2001 | Journal of Thermal Science2001，10，4： | 3 |
| 16 | Impact of laparoscopic liver resection for hepatocellular carcinoma with F4-liver cirrhosis显示文摘 | Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Sadaaki Yamazoe Satoshi Yamamoto Shoji Kubo | 2013 | Surgical Endoscopy2013，，7： | 3 |
| 17 | Laparoscopic liver resection for treating recurrent hepatocellular carcinoma显示文摘 | Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Satoshi Yamamoto Sadaaki Yamazoe Go Ohira Takayoshi Nakajima | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，5： | 3 |
| 18 | Duodenal-type follicular lymphoma more than 10 years after treatment intervention:A retrospective single-center analysis显示文摘BACKGROUND Duodenal-type follicular lymphoma(D-FL)has been recognized as a rare entity that accounts for approximately 4%of primary gastrointestinal lymphomas.D-FL follows an indolent clinical course compared with common nodal FL and is generally considered to have a better prognosis.Therefore,the“watch and wait”approach is frequently adopted as the treatment method.Alternatively,there is an option to actively intervene in D-FL.However,the long-term outcomes of such cases are poorly understood.AIM To clarify the clinical outcomes after long-term follow-up in cases of D-FL with treatment intervention.METHODS We retrospectively analyzed patients who met the following criteria:the lesion was confirmed by endoscopy,the diagnosis of D-FL was confirmed histopathologically,and the patient was followed-up for more than 10 years after the intervention at our center.RESULTS We identified 5 cases of D-FL.Two patients showed a small amount of bone marrow involvement(Stage IV).Rituximab was used as a treatment for remission in all 5 patients.It was also used in combination with chemotherapy in 2 Stage IV patients as well as for maintenance treatment.Radiation therapy was performed in 2 cases,which was followed by complete remission(CR).Eventually,all 5 patients achieved CR and survived for more than 10 years.However,3 patients experienced recurrence.One patient achieved a second CR by retreatment,and in another case,the lesion showed spontaneous disappearance.The remaining patient had systemic widespread recurrence 13 years after the first CR.Biopsy results suggested that the FL lesions were transformed into diffuse large B-cell lymphoma.The patient died 4 years later despite receiving various chemotherapies.CONCLUSION In this study,the treatment for patients of D-FL in Stage IV was successful.In the future,criteria for how to treat“advanced”D-FL should be established based on additional cases.This study of patients with D-FL indicates that whole-body follow-up examinations should continue for a long time due to a fatal recurrence 13 years after reaching CR. | Makoto Saito Akio Mori Shihori Tsukamoto Takashi Ishio Emi Yokoyama Koh Izumiyama Masanobu Morioka Takeshi Kondo Hirokazu Sugino | 2022 | World Journal of Gastrointestinal Oncology2022，14，8： | 3 |
| 19 | Measurement and Numerical Simulation of a Small Centrifugal Compressor Characteristics at Small or Negative Flow Rate显示文摘For centrifugal compressors used in automotive turbochargers, the extension of the surge margin is demanded because of lower engine speed. In order to estimate the surge line exactly, it is required to acquire the compressor characteristics at small or negative flow rate. In this paper, measurement and numerical simulation of the characteristics at small or negative flow rate are carried out. In the measurement, an experimental facility with a valve immediately downstream of the compressor is used to suppress the surge. In the numerical work, a new boundary condition that specifies mass flow rate at the outlet boundary is used to simulate the characteristics around the zero flow rate region. Furthermore, flow field analyses at small or negative flow rate are performed with the numerical results. The separated and re-circulated flow fields are investigated by visualization to identify the origin of losses. | Kaname Tsukamoto Mizuki Okada Yuzo Inokuchi Nobuhiko Yamasaki Akihiro Yamagata | 2017 | Journal of Thermal Science2017，26，2： | 3 |
| 20 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
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