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| 1 | Novel treatment options for perforations of the upper gastrointestinal tract:Endoscopic vacuum therapy and over-the-scope clips显示文摘Endoscopic management of leakages and perforations of the upper gastrointestinal tract has gained great importance as it avoids the morbidity and mortality of surgical intervention.In the past years,covered selfexpanding metal stents were the mainstay of endoscopic therapy.However,two new techniques are now available that enlarge the possibilities of defect closure:endoscopic vacuum therapy(EVT),and over-the-scope clip(OTSC).EVT is performed by mounting a polyurethane sponge on a gastric tube and placing it into the leakage.Continuous suction is applied via the tube resulting in effective drainage of the cavity and the induction of wound healing,comparable to the application of vacuum therapy in cutaneous wounds.The system is changed every 3-5 d.The overall success rate of EVT in the literature ranges from 84%to 100%,with a mean of 90%;only few complications have been reported.OTSCs are loaded on a transparent cap which is mounted on the tip of a standard endoscope.By bringing the edges of the perforation into the cap,by suction or by dedicated devices,such as anchor or twin grasper,the OTSC can be placed to close the perforation.For acute endoscopy associated perforations,the mean success rate is 90%(range:70%-100%).For other types of perforations(postoperative,other chronic leaks and fistulas)success rates are somewhat lower(68%,and59%,respectively).Only few complications have been reported.Although first reports are promising,further studies are needed to define the exact role of EVT and OTSC in treatment algorithms of upper gastrointestinal perforations. | Rudolf Mennigen Norbert Senninger Mike G Laukoetter | 2014 | World Journal of Gastroenterology2014，20，24： | 25 |
| 2 | The consensus on liver autotransplantation from an international panel of experts显示文摘Introduction More than 1.0 million patients worldwide are diagnosed with space-occupying lesions in the liver every year,with the number approaching0.5 million per year in China,and only 20%of the lesions are resectable.^([1,2])Due to a lack of available donors,only a limited number of patients underwent allogeneic liver transplantation,the remaining patients | Qi-Fa Ye Norbert Senninger | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 3 |
| 3 | Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas显示文摘 | Soeren Torge Mees MD Wolf Arif Mardin MD Sonja Sielker Edith Willscher Norbert Senninger PhD Christina Schleicher MD Mario Colombo-Benkmann PhD Joerg Haier PhD | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
| 4 | Current practice patterns in pancreatic surgery: Results of a multi-institutional analysis of seven large surgical departments in germany with 1454 pancreatic head resections, 1999 to 2004 (german advanced surgical treatment study group)显示文摘 | Frank Makowiec M.D. Stefan Post M.D. Hans-Detlev Saeger M.D. Norbert Senninger M.D. F.A.C.S. Heinz Becker M.D. F.A.C.S. Michael Betzler M.D. Heinz J. Buhr M.D. F.A.C.S. Ulrich T. Hopt M.D | 2005 | Journal of Gastrointestinal Surgery2005，，8： | 1 |
| 5 | Early Identification of Peritonitis by Peritoneal Cytokine Measurement显示文摘 | Ralf Herwig Bernhard Glodny Christiane Kühle Bernhard Schlüter Olaf A. Brinkmann Hannes Strasser Norbert Senninger Günther Winde | 2002 | Diseases of the Colon & Rectum2002，，4： | 1 |
| 6 | Metallothionein: Early marker in the carcinogenesis of ulcerative colitis-associated colorectal carcinoma显示文摘 | Matthias Bruewer M.D. Kurt W. Schmid M.D. Christian F. Krieglstein M.D. Norbert Senninger M.D. Guido Schuermann M.D | 2002 | World Journal of Surgery2002，，6： | 1 |
| 7 | Population-Based Analysis of 4113 Patients With Acute Cholecystitis: Defining the Optimal Time Point for Laparoscopic Cholecystectomy显示文摘 | Christina Haane Wolf Arif Mardin Norbert Senninger Soeren Torge Mees | 2014 | Annals of Surgery2014，，1： | 1 |
| 8 | Endo–vacuum Assisted Closure Treatment for Rectal Anastomotic Insufficiency显示文摘 | Soeren Torge Mees M.D. Daniel Palmes M.D. Rudolf Mennigen M.D. Norbert Senninger Ph.D. Joerg Haier Ph.D. Matthias Bruewer Ph.D | 2008 | Diseases of the Colon & Rectum2008，，4： | 1 |
| 9 | Intestinal cancer in patients with Crohn’s disease显示文摘 | Sabine Kersting Matthias Bruewer Mike G. Laukoetter Emile M. Rijcken Rudolf Mennigen Horst Buerger Norbert Senninger Christian F. Krieglstein | 2007 | International Journal of Colorectal Disease2007，，4： | 1 |
| 10 | Single-Incision Laparoscopic Surgery for Ileocolic Resection in Crohn?s Disease显示文摘 | Emile Rijcken Rudolf Mennigen Ioannis Argyris Norbert Senninger Matthias Bruewer | 2012 | Diseases of the Colon & Rectum2012，，： | 1 |
| 11 | Reticuloendothelial System Blockade Promotes Progression from Mild to Severe Acute Pancreatitis in the Opossum显示文摘 | Christina Schleicher Jens C. Baas Hubert Elser Norbert Senninger | 2001 | Annals of Surgery2001，，4： | 1 |
| 12 | Effective prevention of adhesions with htaluronate显示文摘 | Norbert Senninger MD Hermann Herbst Mdet | 2002 | Arch Surg2002，137，3： | 1 |
| 13 | Laparoscopic simulation training: does timing impact the quality of skills acquisition?显示文摘 | Esther M. Bonrath Mathias Fritz Soeren T. Mees Barbara K. Weber Teodor P. Grantcharov Norbert Senninger Emile Rijcken | 2013 | Surgical Endoscopy2013，，3： | 1 |
| 14 | Oxygenation of Liver Transplants as a Predictor of Success显示文摘OxygenationofLiverTransplantsasaPredictorofSuccessYEQifa(DepartmentofSurgery,TongjiHospital,TongjiMedicalUniversity,Wuhan4300... | YE Qifa (Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030)Norbert Senninger (Surgical Clinical University, Heidelberg , Germany) | 1996 | Journal of Huazhong University of Science and Technology(Medical Sciences)1996，16，4： | 1 |
| 15 | Integrins can directly mediate metastatic tumor cell adhesion within the liver sinusoids显示文摘 | Andreas Enns Peter Gassmann M.D. Kerstin Schlüter Timo Korb Hans-Ullrich Spiegel M.D. Ph.D. Norbert Senninger M.D. Ph.D. F.A.C.S. J?rg Haier M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，8： | 1 |
| 16 | Endoscopic Ultrasound with Conventional Probe and Miniprobe in Preoperative Staging of Esophageal Cancer显示文摘 | Rudolf Mennigen Dirk Tuebergen Gabriele Koehler Cristina Sauerland Norbert Senninger Matthias Bruewer | 2008 | Journal of Gastrointestinal Surgery2008，，2： | 1 |
| 17 | Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas显示文摘 | Soeren Torge Mees MD Wolf Arif Mardin MD Sonja Sielker Edith Willscher Norbert Senninger PhD Christina Schleicher MD Mario Colombo-Benkmann PhD Joerg Haier PhD | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
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