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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 3 | The newly established human hepatocyte cell line:application for the bioartificial liver显示文摘 | Norifumi H Akinobu T Dai K | 2005 | J Hepatol2005，42，4： | 1 |
| 4 | Hydrogeochemical modeling for natural analogue study of CO2 leakage due to Matsushiro earthquake swarm 显示文摘 | Norifumi T Shigetaka N | 2009 | Energy Procedia2009，1，1： | 1 |
| 5 | Fluvoxamine rescues mitochondrial Ca2+transport and ATP production throughσ(1)-receptor in hypertrophic cardiomyocytes显示文摘 | Hideaki T Shenuarin B Md Norifumi S | | Life Sci0，95，2： | 1 |
| 6 | Synthesis of spherical LiMn2O4microparticles by a combination of spray pyrolysis and dryingmethod显示文摘 | Izumi T Norifumi F Muxina K | 2008 | Powder Technol2008，181，3： | 1 |
| 7 | Novel hydrogen peroxide metabolism in suspension cells of Scutellaria baicalensis Georgi显示文摘 | SATOSHI M NORIFUMI T TOMUKO M | 1998 | J Biol Chem1998，273，12： | 1 |
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