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4篇 您的检索式：作者名="Norihiro Ueda"

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		题名	作者	年代	出处	被引量
	1	Zero-strain insertion material of LiO4 for rechargeable lithium cells显示文摘	Tsutomu Ohzuku Atsushi Ueda Norihiro Yamamoto	1995	J Electrochem Soc1995，142，：	1
	2	ANTI-INTERLEUKIN 6 (IL-6) RECEPTOR ANTIBODY SUPPRESSES CASTLEMAN’S DISEASE LIKE SYMPTOMS EMERGED IN IL-6 TRANSGENIC MICE显示文摘	Asao Katsume Hiroyuki Saito Yoshiki Yamada Keigo Yorozu Otoya Ueda Ken-Ichi Akamatsu Norihiro Nishimoto Tadamitsu Kishimoto Kazuyuki Yoshizaki Yoshiyuki Ohsugi	2002	Cytokine2002，，6：	1
	3	BCR–ABL-specific CD4^(+) T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells显示文摘The advent of tyrosine kinase inhibitor(TKI)therapy markedly improved the outcome of patients with chronic-phase chronic myeloid leukemia(CML).However,the poor prognosis of patients with advanced-phase CML and the lifelong dependency on TKIs are remaining challenges;therefore,an effective therapeutic has been sought.The BCR–ABL p210 fusion protein’s junction region represents a leukemia-specific neoantigen and is thus an attractive target for antigen-specific T-cell immunotherapy.BCR–ABL p210 fusion-region-specific CD4+T-helper(Th)cells possess antileukemic potential,but their function remains unclear.In this study,we established a BCR–ABL p210 b3a2 fusion-region-specific CD4+Th-cell clone(b3a2-specific Th clone)and examined its dendritic cell(DC)-mediated antileukemic potential.The b3a2-specific Th clone recognized the b3a2 peptide in the context of HLA-DRB109:01 and exhibited a Th1 profile.Activation of this clone through T-cell antigen receptor stimulation triggered DC maturation,as indicated by upregulated production of CD86 and IL-12p70 by DCs,which depended on CD40 ligation by CD40L expressed on b3a2-specific Th cells.Moreover,in the presence of HLA-A24:02-restricted Wilms tumor 1(WT1)235–243 peptide,DCs conditioned by b3a2-specific Th cells efficiently stimulated the primary expansion of WTI-specific cytotoxic T lymphocytes(CTLs).The expanded CTLs were cytotoxic toward WT1235–243-peptide-loaded HLA-A*24:02-positive cell lines and exerted a potent antileukemic effect in vivo.However,the b3a2-specific Th-clone-mediated antileukemic CTL responses were strongly inhibited by both TKIs and interferon-α.Our findings indicate a crucial role of b3a2-specific Th cells in leukemia antigen-specific CTL-mediated immunity and provide an experimental basis for establishing novel CML immunotherapies.	Norihiro Ueda Rong Zhang Minako Tatsumi Tian-YiLiu Shuichi Kitayama YutakaYasui Shiori Sugai Tatsuaki Iwama Satoru Senju Seiji Okada Tetsuya Nakatsura Kiyotaka Kuzushima Hitoshi Kiyoi Tomoki Naoe Shin Kaneko Yasushi Uemura	2018	Cellular & Molecular Immunology2018，15，1：	1
	4	S100A4 mRNA is a Diagnostic and Prognostic Marker in Pancreatic Carcinoma显示文摘	Naoki Ikenaga Kenoki Ohuchida Kazuhiro Mizumoto Jun Yu Hayato Fujita Kohei Nakata Junji Ueda Norihiro Sato Eishi Nagai Masao Tanaka	2009	Journal of Gastrointestinal Surgery2009，，10：	1

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