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| 1 | Caffeine therapy in preterm infants显示文摘Caffeine is the most commonly used medication for treatment of apnea of prematurity. Its effect has been well established in reducing the frequency of apnea, intermittent hypoxemia, and extubation failure in mechanically ventilated preterm infants. Evidence for additional short-term benefits on reducing the incidence of bronchopulmonary dysplasia and patent ductus arteriosus has also been suggested. Controversies existamong various neonatal intensive care units in terms of drug efficacy compared to other methylxanthines, dosage regimen, time of initiation, duration of therapy, drug safety and value of therapeutic drug monitoring. In the current review, we will summarize the available evidence for the best practice in using caffeine therapy in preterm infants. | Hesham Abdel-Hady Nehad Nasef Abd Elazeez Shabaan Islam Nour | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 25 |
| 2 | Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance显示文摘Objective: To check biofilm formation by Acinetobacter baumannii(A. baumannii)clinical isolates and show their susceptibility to different antibiotics and investigate a possible link between establishment of biofilm and multidrug resistance.Methods: This study was performed on clinical samples collected from patients with nosocomial infections in three hospitals of Tehran. Samples were initially screened by culture and biochemical tests for the presence of different species of Acinetobacter. Identifications were further confirmed by PCR assays. Their susceptibilities to 11 antibiotics of different classes were determined by disc diffusion method according to Clinical and Laboratory Standards Institute guidelines. The ability to produce biofilm was investigated using methods: culture on Congo red agar, microtiter plate, and test tube method.Results: From the overall clinical samples, 156 specimens were confirmed to contain A. baumannii. The bacteria were highly resistant to most antibiotics except polymyxin B.Of these isolates, 10.26% were able to produce biofilms as shown on Congo red agar.However, the percentage of bacteria with positive biofilm in test tube, standard microtiter plate, and modified microtiter plate assays were 48.72%, 66.66%, and 73.72%, respectively. At least 92% of the biofilm forming isolates were multidrug resistant.Conclusions: Since most of the multidrug resistant strains produce biofilm, it seems necessary to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii. This would help to select the most appropriate antibiotic for treatment. | Ebrahim Babapour Azam Haddadi Reza Mirnejad Seyed-Abdolhamid Angaji Nour Amirmozafari | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 13 |
| 3 | 橄榄渣基活性炭活化工艺的优化(英文)显示文摘采用KOH对橄榄渣进行活化得到活性炭。设计2~3正交试验来优化制备工艺条件,水平和因子包括活化温度(600,900℃)、活化时间(1,3 h)和浸渍比(1∶2,1∶4)。活性炭的比表面积作为优化的评价指标。通过氮吸附仪、红外光谱仪和扫描电镜等手段对活性炭的表面化学和孔结构进行表征。结果表明,所有因子及其交互水平都非常显著(p<0.05)。活性炭的比表面积和制备条件的相关系数为99.2%。在最条件下制备的活性炭,比表面积为672 m^2/g、平均孔径为2.05 nm,微孔和介孔率分别为81.36%和18.37%。 | Nour T.Abdel-Ghani Ghadir A.El-Chaghaby Mohamed H.ElGammal El-Shaimaa A.Rawash | 2016 | 新型炭材料2016，31，5： | 9 |
| 4 | IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer显示文摘In secondary lymphoid organs,mature B cells express membrane immunoglobulin(Ig)of M and D isotypes(IgM and IgD,respectively)of the same specificity through alternative splicing of a pre-mRNA encompassing the VDJ variable region and Cμand Cδheavy chain constant exons.1 After encountering antigen,B cells undergo class switch recombination(CSR)by which the Cμgene is substituted with Cγ,Cεor Cα,thereby generating IgG,IgE and IgA antibodies of the same antigenic specificity but with new effector functions.CSR requires the DNA-editing enzyme activation-induced deaminase(AID). | Hussein Issaoui Nour Ghazzaui Alexis Saintamand Yves Denizot François Boyer | 2017 | Cellular & Molecular Immunology2017，14，10： | 6 |
| 5 | An Open Platform for Processing IFC Model Versions显示文摘The IFC initiative from the International Alliance of Interoperability has been developing since the mid-nineties through several versions. This paper addresses the problem of binding the growing number of IFC versions and their EXPRESS definitions to programming environments (Java and .NET). The solution developed in this paper automates the process of generating early binding classes, whenever a new version of the IFC model is released. Furthermore, a runtime instantiation of the generated early binding classes takes place by importing IFC-STEP ISO 10303-P21 models. The user can navigate the IFC STEP model with relevance to the defining EXPRESS-schema, modify, delete, and create new instances. These functionalities are considered to be a basis for any IFC based implementation. It enables researchers to experiment the IFC model independently from any software application. | Mohamed Nour Karl Beucke | 2008 | Tsinghua Science and Technology2008，13，S1： | 5 |
| 6 | Partially or Totally Replacing Fish Meal with Frozen Artemia as a Dietary Protein Source for Early Stage Giant Freshwater Prawn, Macrobrachium rosenbergii Post Larvae Reared under Controlled Conditions显示文摘 | A. O. Eglal A. M. A. S. Goda A. M. Nour M. E. Nagy H. A. Mabrouk S. M. A. Hebalah | 2011 | Journal of Agricultural Science and Technology(B)2011，1，6： | 5 |
| 7 | The IgH 3′ regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage显示文摘The bone marrow-derived B2 population represents the vast majority of bone marrow,blood,lymph node and splenic B-cells.Mouse B1 B-cells mostly originate during embryonic life in the liver and represent the main B-cell population in the pleural and peritoneal cavities.1,2,3,4,5 B1 and B2 B-cells differ in their origin,antigen specificity,cell surface markers,tissue distribution and capacity for class switch recombination(CSR).Schematically,B1 B-cells appear earlier than B2 B-cells during fetal development and maintain their self-renewal ability throughout their life. | Hussein Issaoui Nour Ghazzaui Alexis Saintamand Claire Carrion Christelle Oblet Yves Denizot | 2018 | Cellular & Molecular Immunology2018，15，3： | 4 |
| 8 | Bioactive Materials:A Comprehensive Review on Interactions with Biological Microenvironment Based on the Immune Response显示文摘Application of“bioactive materials”,as a modified version of biomaterials,can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation.However,choosing an appropriate bioactive material that suits to the application and provides the desired mechanical,physical,chemical and biological functionality,as well as understanding the aspects of biological reaction to the biomaterial,in particular immune response,it plays a key role in successful integration of the implant.In this review,we will discuss different bioactive materials including bioactive ceramics,polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent studies.Considering the necessity of regulation of implant fate for higher biocompatibility,the comprehensive overview to the immune response will be reviewed with the focus on representing the cell-biomaterial interactions and more importantly,the inflammatory responses.Ultimately,we will also discuss about different approaches namely as immunomodulation to elicit the desired physiochemical properties and mimicking native cellular response using bioactive compounds,functionalizing the implant surface with active molecules and alteration of the surface morphology.With better understanding of bioactive materials and their interactions with body,more novel biomaterials representing desired properties can be designed. | Shirin Nour Nafiseh Baheiraei Rana Imam Navid Rabiee Mohammad Khodaei Akram Alizadeh Seyed Mohammad Moazzeni | 2019 | Journal of Bionic Engineering2019，16，4： | 4 |
| 9 | A Flocking-Based on Demand Routing Protocol for Unmanned Aerial Vehicles显示文摘研究人员的某社区显示出到自治雄蜂或 UAV (无人的天线车辆) 的兴趣与无线通讯网络的来临增加了。这些网络允许 UAV 以一种特定的方式更高效地合作以便在特定的环境完成特定的任务。到那么,当保持经由收音机连接在它的组与另外的节点连接了时,每只雄蜂独立地遨游。这个连接能故意被维持一会儿抑制雄蜂的活动性。这将对涉及在来源和一个目的地之间的给定的传播的一条给定的路径的雄蜂合适。这限制能在传播过程的结束被移开,每只担心的雄蜂的活动性从其它变得再独立。在这个工作,我们建议为 UAV 的一个基于成群的路由协议叫了 BR-AODV。协议为当数据正在被播送时,维持的连接和线路为雷纳兹机制的按需的线路计算,和 Boids 利用一个众所周知的特定的路由协议。而且,自动扎根的基础车站发现机制为为即时应用程序的上下文需要的一个积极雄蜂和地面网络协会被介绍了。BR-AODV 的表演被评估,与古典 AODV 路由的相比,协议和结果证明 BR-AODV 以延期,产量和包损失超过 AODV。 | Nour El Houda Bahloul Saadi Boudjit Marwen Abdennebi Djallel Eddine Boubiche | 2018 | Journal of Computer Science & Technology2018，33，2： | 3 |
| 10 | Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4–infected Children显示文摘 | Olfat G. Shaker Yasser H. Nassar Zeinab A. Nour Mona El Raziky | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，2： | 3 |
| 11 | CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers显示文摘Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers.Methods We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the groups.Markers that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal PD.Results Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy controls.Assessing the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was generated.Conclusions The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal stage.Our findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD. | Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 12 | Molecular cloning of virB12 gene of Brucella melitensis 16M strain in pET28a vector显示文摘Objective:To clone the virB12 gene in pET28a expression vector for production of recombinant protein to be used as antigenic component for future serological test development.Methods: Brucella melitensis(B.melitensis) 16M strain was cultured and bacterial DNA was extracted by Bioneer AccuPrep~ Genomic DNA Extraction Kit.Oligonucleotide primer pair was designed based on Brucella virB12 gene sequence with BamHI and HindIII restriction site at 5’ end of the forward and reverse primers,respectively.DNA amplification was performed using PrimSTAR~ HS DNA polymerase and the PCK product was purified by DNA AccuPrepGel Purification Kit.Purified DNA was cloned into pJET1.2 cloning vector.VirB12 gene fragment was excised from pJET1.2 asing BamHI/HindIII and subsequendy subcloned into pET28a(+).Results:Brucella virB12 gene was successfully cloned in pJET1.2 and then in pET28a(+) plasmids.PCR and restriction enzyme digestion confirms the procedure.Conclusion:We cloned and expressed the Brucella virB12 gene which could be used as antigenic component for specific serological assay development. | Shiva Mirkalantari Nour Amirmozafari Bahram Kazemi Gholamreza Irajian | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 2 |
| 13 | Enhancing IoT anomaly detection performance for federated learning显示文摘Federated Learning (FL) with mobile computing and the Internet of Things (IoT) is an effective cooperative learning approach. However, several technical challenges still need to be addressed. For instance, dividing the training process among several devices may impact the performance of Machine Learning (ML) algorithms, often significantly degrading prediction accuracy compared to centralized learning. One of the primary reasons for such performance degradation is that each device can access only a small fraction of data (that it generates), which limits the efficacy of the local ML model constructed on that device. The performance degradation could be exacerbated when the participating devices produce different classes of events, which is known as the class balance problem. Moreover, if the participating devices are of different types, each device may never observe the same types of events, which leads to the device heterogeneity problem. In this study, we investigate how data augmentation can be applied to address these challenges and improving detection performance in an anomaly detection task using IoT datasets. Our extensive experimental results with three publicly accessible IoT datasets show the performance improvement of up to 22.9% with the approach of data augmentation, compared to the baseline (without relying on data augmentation). In particular, stratified random sampling and uniform random sampling show the best improvement in detection performance with only a modest increase in computation time, whereas the data augmentation scheme using Generative Adversarial Networks is the most time-consuming with limited performance benefits. | Brett Weinger Jinoh Kim Alex Sim Makiya Nakashima Nour Moustafa K.John Wu | 2022 | Digital Communications and Networks2022，8，3： | 2 |
| 14 | Decline of oil prices and the negative interest rate policy in Japan显示文摘In April 2013,the Bank of Japan(BOJ)introduced an inflation target of 2%with the aim of overcoming deflation and achieving sustainable economic growth.But due to lower international oil prices it was unable to achieve this target and was forced to take further measures.Hence,in February 2016,the BOJ adopted a negative interest rate policy by massively increasing the money supply through the purchase of long-term Japanese government bonds(JGB).The BOJ had previously only purchased short-term government bonds,a policy that flattened the yield curve of JGBs.On the one hand,banks reduced the number of government bonds they purchased because short-term bond yields had become negative.The interest rates of long-term government bond up to 15 years even became negative.On the other hand,bank loans to corporates did not increase,due to Japanese economy’s vertical investment-saving(IS)curve.The purpose of this paper is to show that the monetary policy through implementation of the zero interest rate and more recently through the negative interest rate could not help the Japanese economy to recover from the long-lasting recession and these are not the remedy.It is of key importance to make the IS curve downward rather than vertical.That means the rate of return on investment must be positive and companies must be willing to invest even if interest rates are set too low.Japan’s long-term recession is due to structural problems that cannot be solved by its current monetary policy.The paper also explains why the BOJ has to reduce its 2%inflation target in the present low oil price era. | Naoyuki Yoshino Farhad Taghizadeh-Hesary Nour Tawk | 2017 | Economic and Political Studies2017，5，2： | 2 |
| 15 | The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis显示文摘Hepatic stellate cells(HSCs)are the primary effector cells in liver fibrosis.In the normal liver,HSCs serve as the primary vitamin A storage cells in the body and retain a“quiescent”phenotype.However,after liver injury,they transdifferentiate to an“activated”myofibroblast-like phenotype,which is associated with dramatic upregulation of smooth muscle specific actin and extracellular matrix proteins.The result is a fibrotic,stiff,and dysfunctional liver.Therefore,understanding the molecular mechanisms that govern HSC function is essential for the development of anti-fibrotic medications.The actin cytoskeleton has emerged as a key component of the fibrogenic response in wound healing.Recent data indicate that the cytoskeleton receives signals from the cellular microenvironment and translates them to cellular function—in particular,increased type I collagen expression.Dynamic in nature,the actin cytoskeleton continuously polymerizes and depolymerizes in response to changes in the cellular microenvironment.In this viewpoint,we discuss the recent developments underlying cytoskeletal actin dynamics in liver fibrosis,including how the cellular microenvironment affects HSC function and the molecular mechanisms that regulate the actininduced increase in collagen expression typical of activated HSCs. | NOUR HIJAZI DON C.ROCKEY ZENGDUN SHI | 2022 | BIOCELL2022，46，9： | 2 |
| 16 | High-throughput sequencing reveals similar molecular signatures for class switch recombination junctions for theγandαisotypes显示文摘INTRODUCTION After encountering an antigen,B cells undergo class switch recombination(CSR),which substitutes the Cμgene with Cγ,Cε,or Cαto generate IgG,IgE,and IgA antibodies with the same antigenic specificity but new effector functions.1 The DNAediting enzyme activation-induced deaminase(AID)is essential for CSR by targeting switch(S)regions preceding Cμ(namely,the Sμdonor region)and the Cγ,Cε,and Cαgenes(namely,the Sγ,ε,αacceptor regions).1 Cis-and trans-controlled DNA double strand beaks are generated during this process.2–6 Recruitment of DNA repair factors that facilitate the end-joining process is a crucial step of class switch recombination.Two pathways are implicated in this end joining.The classical non-homogenous end joining(c-NHEJ)pathway ligates DNA ends with no or little homology.By contrast,the alternative end joining(A-EJ)pathways is used to ligate DNA ends that have microhomology. | ussein Issaoui Nour Ghazzaui Alexis Saintamand Yves Denizot François Boyer | 2019 | Cellular & Molecular Immunology2019，16，1： | 2 |
| 17 | Uracil-DNA glycosylase is not implicated in the choice of the DNA repair pathway during B-cell class switch recombination显示文摘Mature B-cells express membrane IgM and IgD(of same specificity)through alternative splicing of a pre-mRNA encompassing constant(C)μand Cδgenes.After encountering antigen,Bcells undergo class switch recombination(CSR)that substitutes the Cμgene with Cγ,Cε,or Cα,thereby generating IgG,IgE,and IgA antibodies with the same antigenic specificity but new effector functions.DNA-editing enzyme activation-induced deaminase(AID)is essential for CSR by targeting switch(S)regions preceding Cμ(namely,the Sμdonor region)and the Cγ,Cε,and Cαgenes(namely,the Sγ,ε,αacceptor regions).1,2 CSR is controlled in cis by IgH locus super-enhancers3 and in trans by a wide spectrum of enzymes and proteins.1,2 Among them,the role of the uracil DNA glycosylase(UNG)remains controversial.UNG is a key enzyme of base excision repair,which carries out faithful repair.Some authors estimate that during CSR,the UNG enzymatic activity removes the AID-induced dC to dU converted base of singlestrand DNA,generating abasic sites and leading to DNA strand breaks.1 For other authors,the role of UNG is to stabilize the S–S synapse and to recruit DNA repair factors that facilitate the endjoining process.4,5 Thus,the classical non-homogenous end joining pathway would be increased over the alternative end joining(A-EJ)pathway in UNG-deficient mice,4 suggesting an intriguing role of UNG in promoting the A-EJ pathway. | Nour Ghazzaui Hussein Issaoui Alexis Saintamand Yves Denizot François Boyer | 2019 | Cellular & Molecular Immunology2019，16，1： | 2 |
| 18 | Intestinal transplantation with or without other abdom inal organs : nutr itional and dietary management of 50 patients显示文摘 | Nour B Reyes A Tzakis S etal | 1994 | Transplant Proc1994，26，3： | 1 |
| 19 | Three stage no-idle flow shop显示文摘 | Saadani Nour El Guinet Alain Moalla Mohamed | 2003 | Computers & Industrial Engineering2003，44，3： | 1 |
| 20 | Significance of soil dilatancy in slope stability analysis显示文摘 | Manzari M T Nour M A | 2000 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2000，126，1： | 1 |
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