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| 1 | 在心血管的疾病的先进 glycation 结束产品的角色显示文摘 Advanced glycation end products(AGEs) are produced through the non enzymatic glycation and oxidation of proteins,lipids and nucleic acids.Enhanced formation of AGEs occurs particularly in conditions associated with hyperglycaemia such as diabetes mellitus(DM).AGEs are believed to have a key role in the development and progression of cardiovascular disease in patients with DM through the modif ication of the structure,function and mechanical properties of tissues through crosslinking intracellular as well as extracellular matrix proteins and through modulating cellular processes through binding to cell surface receptors [receptor for AGEs(RAGE)].A number of studies have shown a correlation between serum AGE levels and the development and severity of heart failure(HF).Moreover,some studies have suggested that therapies targeted against AGEs may have therapeutic potential in patients with HF.The purpose of this review is to discuss the role of AGEs in cardiovascular disease and in particular in heart failure,focussing on both cellular mechanisms of action as well as highlighting how targeting AGEs may represent a novel therapeutic strategy in the treatment of HF. | Zeinab Hegab Stephen Gibbons Ludwig Neyses Mamas A Mamas | 2012 | World Journal of Cardiology2012，4，4： | 58 |
| 2 | An overview of occult hepatitis B virus infection显示文摘Occult hepatitis B virus (HBV) infection (OBI), alternatively defined as occult hepatitis B (OHB), is a challenging clinical entity. It is recognized by two main characteristics: absence of HBsAg, and low viral replication. The previous two decades have witnessed a remarkable progress in our understanding of OBI and its clinical implications. Appropriate diagnostic techniques must be adopted. Sensitive HBV DNA amplification assay is the gold standard assay for detection of OBI. Viral as well as host factors are implicated in the pathogenesis of OBI. However, published data reporting the infectivity of OBI by transfusion are limited. Several aspects including OBI transmission, infectivity and its relation to the development of chronic liver diseases and hepatocellular carcinoma have to be resolved. The aim of the present review is to highlight recent data on OBI with a focus on its virological diagnosis and clinical outcome. | Zeinab Nabil Ahmed Said | 2011 | World Journal of Gastroenterology2011，17，15： | 20 |
| 3 | Human umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model显示文摘AIM:To investigate the effect of human umbilical cord stem cells,both mesenchymal and hematopoietic(CD34+),in the treatment of arthritis.METHODS:Mesenchymal stem cells(MSCs) and hematopoietic(CD34+) stem cells(HSC) were isolated from human umbilical cord blood obtained from the umbilical cord of healthy pregnant donors undergoing fullterm normal vaginal delivery.MSC,HSC,methotrexate(MTX) and sterile saline were injected intra-articularly into the rat hindpaw with complete freunds adjuvant(CFA) induced arthritis after the onset of disease(day 34),when arthritis had become well established(arthritis score ≥ 2).Arthritic indices were evaluated and the levels of interleukin(IL)-1,tumor necrosis factor(TNF)-α and interferon(IFN)-γ and anti-inflammatory cytokine IL-10 in serum were determined using enzyme-linked immunosorbent assay.Animals of all groups were sacrificed 34 d after beginning treatment,except positive control(PC) which was sacrificed at 10,21 and 34 d for microscopic observation of disease progression.We used hematoxylin,eosin and Masson's trichrome stains for histopathological examination of cartilage and synovium.RESULTS:The mean arthritis scores were similar in all groups at 12 and 34 d post immunization,with no statistical significant difference.Upon the injection of stem cells(hematopoietic and mesenchymal),the overall arthritis signs were significantly improved around 21 d after receiving the injection and totally disappeared at day 34 post treatment in MSC group.Mean hindpaw diameter(mm) in the MSC rats was about half that of the PC and MTX groups(P = 0.007 and P = 0.021,respectively) and 0.6 mm less than the HSC group(P = 0.047),as indicated by paw swelling.Associated with these findings,serum levels of TNF-α,IFN-γ and IL-1 decreased significantly in HSC and MSC groups compared to PC and MTX groups(P < 0.05),while the expression of IL-10 was increased.Histopathological examination with H and E stain revealed that the MTX treated group showed significant reduction of leucocytic infiltrate and hypertrophy of the synovial tissue with moderate obliteration of the joint cavity.Stem cells treated groups(both hematopoietic CD34+ and mesenchymal),showed significant reduction in leucocytic infiltrate and hypertrophy of the synovial tissue with mild obliteration of the joint cavity.With Masson's trichrome,stain sections from the PC group showed evidence of vascular edema of almost all vessels within the synovium in nearly all arthritic rats.Vacuoles were also visible in the outer vessel wall.The vessel became hemorrhagic and finally necrotic.In addition,there was extensive fibrosis completely obliterating the joint cavity.The mean color area percentage of collagen in this group was 0.324 ± 0.096,which was significantly increased when compared to the negative control group.The mean color area percentage of collagen in hematopoietic CD34+ and mesenchymal groups was 0.176 ± 0.0137 and 0.174 ± 0.0197 respectively,which showed a marked decrement compared to the PC group,denoting a mild increase in synovial tissue collagen fibers.CONCLUSION:MSC enhance the efficacy of CFAinduced arthritis treatment,most likely through the modulation of the expression of cytokines and amelioration of pathological changes in joints. | Sahar Greish Noha Abogresha Zeinab Abdel-Hady Eman Zakaria Mona Ghaly Mohamed Hefny | 2012 | World Journal of Stem Cells2012，4，10： | 17 |
| 4 | 中国大陆34家医院ⅠB2、ⅡA2期宫颈癌新辅助化疗不同方案的近期疗效对比显示文摘目的探讨ⅠB2、ⅡA2期宫颈癌新辅助化疗不同方案的近期疗效差异。方法回顾性分析2004—2016年中国大陆34家医院30 665例宫颈癌病例,筛选术前活检确诊、FIGO分期ⅠB2及ⅡA2期、新辅助化疗+手术治疗、资料完整的1064例患者,根据化疗方案,分为紫杉醇类+顺铂(TP)组(A组)、紫杉醇类+非顺铂铂类(TC)组(B组)、顺铂+其他药物组(C组)、非顺铂铂类+其他药物组(D组),以妇科检查结合影像学检查评估新辅助化疗前后局部病灶大小的变化,比较不同化疗方案近期疗效差异。结果 (1)四组方案新辅助化疗有效率71.43%(280/392)、62.54%(187/299)、64.31%(200/311)、67.74%(42/62),差异无统计学意义(P>0.05)。(2)2009年以前C+D组化疗方案比例均超50.00%,此后A+B组比例上升;比较C、D组,C组方案在不同时间比例均超52.00%;比较A、B组,2013年前A方案比例高于B方案,此后,B方案比例达61.11%,并呈上升趋势。结论 (1)ⅠB2、ⅡA2期宫颈癌患者采用四组常见方案新辅助化疗效果均理想,近期疗效相似。(2)化疗方案呈现出随时间变化的趋势:2009年以前,铂类+非紫杉醇类药物方案是主流方案,其中顺铂使用最广泛;2009年以后紫杉醇类+铂类方案开始广泛应用,其中2013年以前TP方案是主流,2013年后,TC方案逐渐超过TP方案成为主流。 | 林善群 Zeinab Yusuf Ali 王璐 霍智锋 陈春林 康山 王武亮 朱前勇 倪妍 陆安伟 李东林 刘萍 郎景和 | 2018 | 中国实用妇科与产科杂志2018，34，7： | 11 |
| 5 | Dietary supplementation in patients with alcoholic liver disease: a review on current evidence显示文摘BACKGROUND:Alcoholic liver disease(ALD)is one of the main causes of liver disease worldwide.Although the pathogenesis of ALD has not yet been well elucidated,the oxidative metabolites of ethanol such as acetaldehyde and reactive oxygen species play a pivotal role in the clinical and pathological spectrum of the disease.This review summarizes the existing evidences on dietary supplements considered to have antioxidant,and/or anti-inflammatory properties,and their role in the management of ALD and the proposed mechanisms.DATA SOURCES:The present study reviewed all studies published in Pub Med,Science Direct and Scopus,from 1959 to2015,indicating the role of different dietary supplementation in attenuation of many pathophysiological processes involved in development and progression of ALD.Full-texts of citations were used except for those that were published in languages other than English.RESULTS:Significant progress has been made to understand the key events and molecular players for the onset and progression of ALD from both experimental and clinical studies;however,there is no successful treatment currently available.The present review discussed the role of a variety of dietary supplements(e.g.vitamin A,carotenoids,vitamins B3,C and E,in addition to antioxidants and anti-inflammatory agents)in treating ALD.It has been shown that supplementation with some carotenoids,vitamin B3,vitamin C,silymarin,curcumin,probiotics,zinc,S-adenosylmethionine and garlic may havepotential beneficial effects in animal models of ALD;however,the number of clinical studies is very limited.In addition,supplementation should be accompanied with alcohol cessation.CONCLUSIONS:Since oxidative stress and inflammation are involved in the pathogenesis of ALD,dietary supplements that can modulate these pathologies could be useful in the treatment of ALD.In addition to alcohol cessation,these supplements have shown beneficial effects on animal models of ALD.Clinical trials are needed to validate the beneficiary role of these supplements in patients with ALD. | Zeinab Ghorbani Masoomeh Hajizadeh Azita Hekmatdoost | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，4： | 8 |
| 6 | Modification in Media Composition to Obtain Secretory Production of STxB-based Vaccines using Escherichia coli显示文摘Shiga toxin B-subunit (STxB) from Shigella dysenteriae targets in vivo antigen to cancer cells, dendritic cells (DC) and B cells, which preferentially express the globotriaosylceramide (Gb3) receptor. This pivotal role has encouraged scientists to investigate fusing STxB with other clinical antigens. Due to the challenges of obtaining a functional soluble form of the recombinant STxB, such as formation of inclusion bodies during protein expression, scientists tend to combine STxB with vaccine candidates rather than using their genetically fused forms. In this work, we fused HPV16 E7 as a vaccine candidate to the recombinantly-produced STxB. To minimize the formation of inclusion bodies, we investigated a number of conditions during the expression procedure. Then various strategies were used in order to obtain high yield of soluble recombinant protein from E. coli which included the use of different host strains, reduction of cultivation temperature, as well as using different concentrations of IPTG and different additives (Glycin, Triton X-100, ZnCl2). Our study demonstrated the importance of optimizing incubation parameters for recombinant protein expression in E. coli; also showed that the secretion production can be achieved over the course of a few hours when using additives such as glycine and Triton X-100. Interestingly, it was shown that when the culture mediums were supplemented by additives, there was an inverse ratio between time of induction (TOI) and the level of secreted protein at lower temperatures. This study determines the optimal conditions for high yield soluble E7-STxB expression and subsequently facilitates reaching a functionally soluble form of STxB-based vaccines, which can be considered as a potent vaccine candidate for cervical cancer. | Mohammad Sadraeian Mohammad Bagher Ghoshoon Milad Mohkam Zeinab Karimi SaraRasoul-Amini Younes Ghasemi | 2013 | Virologica Sinica2013，28，1： | 7 |
| 7 | CO_2 reforming of methane over nickel catalysts supported on nanocrystalline MgAl_2O_4 with high surface area显示文摘In this paper dry reforming of methane (DRM) was carried out over nanocrystalline MgAl2O4-supported Ni catalysts with various Ni loadings. Nanocrystalline MgAl2O4 spinel with high specific surface area was synthesized by a co-precipitation method with the addition of pluronic P123 triblock copolymer as surfactant, and employed as catalyst support. The prepared samples were characterized by X-ray diffraction (XRD), N2 adsorption, H2 chemisorption, temperature-programmed reduction (TPR), temperature-programmed oxidation (TPO), temperature- programmed desorption (TPD) and transmission and scanning electron microscopies (TEM, SEM) techniques. The obtained results showed that the catalyst support has a nanocrystalline structure (crystal size: about 5 nm) with a high specific surface area (175 m2 g-1) and a mesoporous structure. Increasing in nickel content decreased the specific surface area and nickel dispersion. The prepared catalysts showed high catalytic activity and stability during the reaction. SEM analysis revealed that whisker type carbon deposited over the spent catalysts and increasing in nickel loading increased the amount of deposited carbon. The nickel catalyst with 7 wt% of nickel showed the highest catalytic activity. | Narges Hadian Mehran Rezaei Zeinab Mosayebi Fereshteh Meshkani | 2012 | Journal of Natural Gas Chemistry2012，21，2： | 6 |
| 8 | Synthesis, physicochemical characterizations and catalytic performance of Pd/carbon-zeolite and Pd/carbon-Ce02 nanocatalysts used for total oxidation of xylene at low temperatures显示文摘 | Zeinab JAMALZADEH | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 5 |
| 9 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 10 | Distinct element modelling of fracture plan control in continuum and jointed rock mass in presplitting method of surface mining显示文摘Controlled blasting techniques are used to control overbreak and to aid in the stability of the remaining rock formation. Presplitting is one of the most common methods which is used in many open pit mining and surface blast design. The purpose of presplitting is to form a fracture plane across which the radial cracks from the production blast cannot travel. The purpose of this study is to investigate of effect of presplitting on the generation of a smooth wall in continuum and jointed rock mass. The 2D distinct element code was used to simulate the presplitting in a rock slope. The blast load history as a function of time was applied to the inner wall of each blasthole. Important parameters that were considered in the analysis were stress tensor and fracturing pattern. The blast loading magnitude and blasthole spacing and jointing pattern were found to be very significant in the final results. | Sharafisafa Mansour Aliabadian Zeinab Alizadeh Rezvan Mortazavi Ali | 2014 | International Journal of Mining Science and Technology2014，24，6： | 4 |
| 11 | Egg consumption and risk of non-alcoholic fatty liver disease显示文摘AIM To evaluate the association between egg consumption and risk of non-alcoholic fatty liver disease(NAFLD) development.METHODS This case-control study was conducted on individuals who were referred to two hepatology clinics in Tehran, Iran in 2015. The study included 169 patients with NAFLD and 782 controls. Egg consumption was estimated using a validated food frequency questionnaire. The participants were categorized according to the frequency of their egg consumption during the previous year: Less than two eggs per week, two to three eggs per week, and four or more eggs per week.RESULTS In the crude model, participants who consumed 2 to 3 eggs per week, were 3.56 times more likely to have NAFLD in comparison to those who consumed less than 2 eggs per week(OR: 3.56; 95%CI: 2.35-5.31). Adjustment for known risk factors of NAFLD strengthenedthis significant association so that individuals have consumed two to three eggs per week had 3.71 times higher risk of NAFLD than those who have eaten less than two eggs per week(OR: 3.71; 95%CI: 1.91, 7.75). CONCLUSION Our data indicate that higher egg consumption in common amount of usage is associated with higher risk of NAFLD. | Zeinab Mokhtari Hossein Poustchi Tannaz Eslamparast Azita Hekmatdoost | 2017 | World Journal of Hepatology2017，9，10： | 3 |
| 12 | Oxidative coupling of methane over (Na_2WO_4+Mn or Ce)/SiO_2 catalysts:In situ measurement of electrical conductivity显示文摘The effects of manganese oxide or ceria promoters on the performance of Na2WO4/SiO2 catalysts for oxidative coupling of methane (OCM) are reported. The OCM reaction was performed in a continuous-flow microreactor at 800 ℃, atmospheric pressure and under GHSV = 13200 ml gC-1at h-1. Catalysts were characterized by in situ conductivity measurement, FT-IR spectroscopy, XRD, SEM and temperature programmed reduction analysis. Manganese oxide promoted Na2WO4/SiO2 is considered as one of the active and selective catalysts for OCM reaction. Ceria with high oxygen storage capacity is selected as a proper oxygen activator, providing a higher concentration of the oxy-anion species which is suitable for OCM reaction and compared with manganese oxide. Electrical conductivity of the catalysts was measured in OCM reaction under oxidizing atmosphere, i.e. in the absence of methane. It was found that the trimetallic catalysts, i.e. the catalysts having sodium, tungsten and Mn or Ce species, exhibited similar crystalline structures and morphologies, which lead to suitable bulk properties for the formation of an active and selective catalyst. However, tungsten had significant effect on the texture and redox properties of the catalysts. It was also shown that the crystalline structure of the bimetallic (Na+Mn or Ce)/SiO2 samples was quite different. This reveals that the metal oxides have significant effect on the extent of crystallization, taking place in the course of interaction of sodium with silica support. Similar conductivities and catalytic performances of (Na2WO4+Mn or Ce)/SiO2 catalysts propose that the ability of Na2WO4/SiO2 for utilizing oxy-anions formed in presence of different metal oxides is limited. | Zeinab Gholipour Azim Malekzadeh Reza Hatami Yadollah Mortazavi Abasali Khodadadi | 2010 | Journal of Natural Gas Chemistry2010，19，1： | 3 |
| 13 | Ultra-flat dispersion in an integrated waveguide with five and six zero-dispersion wavelengths for mid-infrared photonics显示文摘We propose a new type of dispersion flattening technology, which can generate an ultra-flat group velocity dispersion profile with five and six zero-dispersion wavelengths(ZDWs). The dispersion value varies from-0.15 to 0.35 ps/(nm·km) from 4 to 8 μm, which to the best of our knowledge is the flattest one reported so far, and the dispersion flatness is improved by more than an order of magnitude. We explain the principle of producing six ZDWs. Mode distribution in this waveguide is made stable over a wide bandwidth. General guidelines to systematically control the dispersion value, sign, and slope are provided, and one can achieve the desired dispersion by properly adjusting the structural parameters. Fabrication tolerance of this waveguide is also examined. | Yuhao Guo Zeinab Jafari Lijuan Xu Changjing Bao Peicheng Liao Guifang Li Anuradha M.Agarwal Lionel C.Kimerling Jurgen Michel Alan E.Willner Lin Zhang | 2019 | Photonics Research2019，7，11： | 3 |
| 14 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 15 | 肌酸激酶活性与大鼠衰老关系的研究显示文摘目的 :证实衰老过程中肌酸激酶活性的变化 ,探讨与衰老的关系。方法 :应用 2 4月龄和 8周Sprague-Dawley大鼠作为老年组和青年组 ,过量麻醉处死后 ,测定心脏、脑组织和膀胱重量 ,并用酶法测定血清、心脏、脑组织、膀胱和趾长伸肌肌酸激酶活性。结果 :老年大鼠心脏重量与体重的比值、脑组织重量与体重的比值以及膀胱重量与体重的比值均显著降低 (P <0 .0 0 1) ,老年大鼠血清、心脏、脑组织和骨骼肌肌酸激酶活性显著降低 (P <0 .0 0 1- 0 .0 5 ) ,但膀胱肌酸激酶活性降低无统计学意义。结论 :肌酸激酶活性降低使能量代谢降低 ,可能影响对自由基造成损伤的修复能力 ,从而促进衰老进程 ; | 赵昕 尉秀荣 刘楠 RobertD.Helme Merhi Merhi Maryam Bassirat Khalil Zeinab | 2000 | 中国康复医学杂志2000，15，2： | 3 |
| 16 | Prevalence survey of infection with Treponema pallidum among HIV-positive patients in Tehran显示文摘Objective:To identify the frequency of syphilis among Iranian HIV-positive patients.Methods:A cross-sectional study on the prevalence of syphilis and HIV co-infection among 450 patients diagnosed with HIV infection was conducted between 2004 and 2008 at Imam Khomeini hospital,Tehran,Iran.The lab tests including CD4 cell count,cerebrospinal fluid,veneral disease research laboratory(VDRL),fluorescent treponema antibody-absorption(FTA-Abs)and viral load were performed for all the patients.Data regarding medical history and their demographics were also collected.Results:Of all 450 HIV-positive patients,24(5.3%)had a positive VDRL test and only two men had a FTA-Abs positive test which means 0.45%of them had a definite co-infection of syphilis.65.3%of the HIV-positive patients were injection drug users that the co-infection prevalence of them was 0.7%.We did not find any patient with neurosyphilis.Conclusions:Considering the increasing prevalence of HIV and also extensive use of highly active antiretroviral therapy in developing nations,the diagnosis of syphilis should be timely established using screening tests among such patients. | Banafsheh Moradmand Badie Zeinab Yavari Shooka Esmaeeli Koosha Paydary Sahra Emamzadeh-Fard SeyedAhmad SeyedAlinaghi Mehrnaz Rasoulinejad | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，4： | 3 |
| 17 | Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4–infected Children显示文摘 | Olfat G. Shaker Yasser H. Nassar Zeinab A. Nour Mona El Raziky | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，2： | 3 |
| 18 | Effects of Hydro-alcoholic Extract of Launaea acanthodes on Serum Gonadotropin and Testosterone Levels and the Structure of Seminiferous Tubules in Hyperglycemic Rats显示文摘Objective:To investigate the effects of hydro-alcoholic extract of Launaea acanthodes,a blood glucose lowering plant in folk medicine of Iran,on the structure of seminiferous tubules and serum gonadotropin and testosterone levels in hyperglycemic rats.Methods:Twenty-four Wistar rats were randomly allocated into4 groups(n=6):control,streptozotocin(STZ),STZ+insulin[STZ+Ins,5 IU/(kg·day)],and STZ+Launaea acanthodes extract[STZ+Ext,150 mg/(kg·day)].Blood samples were collected at the 2nd and 4th weeks for detection of testosterone,follicle stimulating hormone(FSH)and luteinizing hormone(LH)with enzyme-linked immuno sorbent assay(ELISA),and the right testes of rats were removed at the 7th week for the evaluation of diameter and wall thickness of seminiferous tubules and number of Leydig cells using unbiased stereological techniques.Results:In comparison with the control group,at the 2nd week FSH(0.45 vs 0.03,0.02,0.02 IU/L in STZ,STZ+Ins and STZ+Ext groups,respectively)and LH(1.02 vs 0.37,0.2,0.29 IU/L)showed significant decreases(all P<0.05)and testosterone(4.2 vs 8.37,7.78,11.8 ng/mL)showed a remarkable increase(all P<0.05).The levels of these hormones became closer in the STZ+Ext and the STZ+Ins groups to the control at the 4th week.A significant decrease in diameter and wall thickness of seminiferous tubules and number of Leydig cells were observed in the STZ group as compared with the control(P<0.01).Conclusions:Administration of Launaea extract demonstrated a beneficial impact on the protection of testis from pathogenic and degenerative effects of hyperglycemia which may be partly due to its potential antioxidative effects. | Ameneh Mohammadi Morteza Behnam-Rassouli Zeinab Momeni Naser Mahdavi-Shahri | 2016 | Chinese Journal of Integrative Medicine2016，22，3： | 2 |
| 19 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 20 | A Controller-Based Architecture for Information Centric Network Construction and Topology management显示文摘Information-Centric Networking(ICN) has recently emerged as a result of the increased demand to access contents regardless of their location in the network services. This new approach facilitates content distribution as a service of the network with lower delay and higher security in comparison with the current IP network. Applying ICN in current IP infrastructure leads to major complexities. One approach to deploy ICN with less complexity is to integrate ICN with Software Defined Networking(SDN). The SDN controller manages the content distribution, caching, and routing based on the users' requests. In this paper, we extend these context by addressing the ICN topology management problem over the SDN network to achieve an improved user experience as well as network performance. In particular, a centralized controller is designed to construct and manage the ICN overlay. Experimental results indicate that this adopted topology management strategy achieves high performance, in terms of low failure in interest satisfaction and reduced download time compared to a plain ICN. | Zeinab Zali Massoud Reza Hashemi Ilaria Cianci Alfredo Grieco Gennaro Boggia | 2018 | China Communications2018，15，7： | 2 |
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