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| 1 | 贝伐单抗治疗湿性年龄相关黄斑变性患者SD-OCT形态学变化(英文)显示文摘目的:研究频域光学相干断层成像(spectral domain optical coherence tomography,SD-OCT)定量和定性检测指标在接受玻璃体腔内注射贝伐单抗的年龄相关性黄斑变性(agerelated macular degeneration,AMD)患者人群中的变化,以评估这些指标是否可以用于预测治疗后视力情况。方法:回顾性分析66眼61例未进行过AMD相关治疗的患者接受至少3mo玻璃体腔内注射贝伐单抗治疗的情况。治疗前后SD-OCT定量检测指标[中央视网膜厚度(central foveal thickness,CFT),外界膜(external limiting membrane,ELM)和椭圆区(ellipsoid zone,EZ)长度]和定性检测指标进行分析和比较。同时,分析这些指标和治疗前后的视力的相关性。结果:平均视力(Log MAR)、CFT、ELM和EZ长度治疗前为0.62±0.41、419.3±110.0μm、378.2±377.2μm和156.4±253.7μm,治疗后为0.53±0.44、325.8±117.9μm、547.1±421.5μm和173.1±207.1μm。治疗前视力和CFT(rs=0.27)、ELM长度(rs=-0.30)及ELM断裂(rs=0.43)有相关性。治疗后视力同样和治疗后ELM长度相关(rs=-0.40)。治疗后视力和治疗前视力(rs=0.66)、ELM长度(rs=-0.35)和ELM断裂(rs=0.46)相关。结论:研究显示:治疗前视力、ELM长度和ELM断裂可以用于预测治疗后视力。 | Manuel Noronha Nuno Moura-Coelho Teresa Gomes Rita Flores Marco Dutra Medeiros | 2017 | 国际眼科杂志2017，17，3： | 3 |
| 2 | Lending relationships in the interbank market显示文摘 | Jo?o F. Cocco Francisco J. Gomes Nuno C. Martins | 2008 | Journal of Financial Intermediation2008，，1： | 1 |
| 3 | Understanding the responsiveness of nitric oxide to acute eccentric resistance exercise in elderly obese women显示文摘Background and Aim:The aim of the present study was to examine nitrite concentration responses following eccentric resistance exercise(ERE)in elderly obese women.We also investigated the existence of high(HR)and low responders(LR)for nitrite and the possible differences with respect to creatine kinase(CK)response,metabolic and body composition variables.Methods:Forty-nine elderly obese women completed an ERE session utilizing knee extensor exercise.LR for serum nitrite were defined as aΔnitrite≤20th percentile or 24.1μmol/L and HR as aΔnitrite>20th percentile.Results:Ten subjects were classified as LR and the remaining as HR(n=39).The HR group displayed greater nitrite concentration at 0 h,3 h,24 h and 48 h following the ERE as compared with the LR(p<0.05),and CK increased after 24 h and 48 h only for the HR group following the ERE(p<0.05).Peak nitrite concentration was higher in the HR group versus the LR group(p<0.05),while there was no difference between groups for pre-exercise nitrite values.The LR group displayed higher(p<0.05)body fat,cholesterol,LDL and lower upper limb fat-free mass as compared with the HR group.The LR had lower(p<0.05)upper limb fat-free mass than the HR group.Conclusions:Elderly obese women classified as HR displayed higher nitrite responses to ERE.Thus,researchers should be aware of the presence of different responsiveness of nitrite to acute exercise to avoid misinterpretation of data and to identify the higher cardiovascular risk factor of those classified as LR.Relevance for patients:The elevated NO up to 48 h following an ERE session may suggest an important protective cardiovascular effect.The higher body fat,cholesterol,LDL and lower upper limb fat-free mass in the LR group might represent a deleterious effect of lower serum levels of nitrite. | Tatiane Gomes Teixeira Dahan da Cunha Nascimento Ramires Alsamir Tibana Nuno Manuel Frade deSousa Vinicius Carolino de Souza Jeeser Alves de Almeida Amilton Vieira Octavio Luiz Franco Guilherme Borges Pereira Jonato Prestes | 2016 | Journal of Clinical & Translational Research2016，2，2： | 0 |
| 4 | Ultrashort pulse capability at the L2I high intensity laser facility显示文摘The Laboratory for Intense Lasers(L2I) is a research centre in optics and lasers dedicated to experimental research in high intensity laser science and technology and laser plasma interaction. Currently the laboratory is undergoing an upgrade with the goal of increasing the versatility of the laser systems available to the users, as well as increasing the pulse repetition rate. In this paper we review the current status of the laser research and development programme of this facility, namely the upgraded capability and the recent progress towards the installation of an ultrashort, diode-pumped OPCPA laser system. | Gonqalo Figueira Joana Alves Joao M.Dias Marta Fajardo Nuno Gomes Victor Hariton Tayyab Imran Celso P.Joao Jayanath Koliyadu Swen Kunzel Nelson C.Lopes Hugo Pires Filipe Ruao Gareth Williams | 2017 | High Power Laser Science and Engineering2017，5，1： | 0 |
| 5 | XEN^(■) implant and trabeculectomy medium-term quality of life assessment and comparison of results显示文摘AIM: To evaluate and compare the quality of life of patients submitted to XEN~? implant or trabeculectomy and the relationship with potentially involved variables.METHODS: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN~?(group 1) and trabeculectomy(group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure(IOP). The quantification of the quality of life was attained through the Glaucoma Symptom Scale(GSS) questionnaire. RESULTS: Totally 34 eyes(34 patients) were included, 17 in each group. The mean GSS scores for group 1 were 42.6±6.8(median, 47; p25, 36.5; p75, 48.5) and for group 2 it was 41.6±7.0(median, 43; p25, 36.5; p75, 47.0; P=0.34). There was a strong negative correlation between the need for topical anti-hypertensive drugs and the GSS result in both groups(r=-0.88, P<0.01, r=-0.59, P=0.01, respectively) and a moderate negative correlation with IOP in group 1(r=-0.50, P=0.03).CONCLUSION: The analysis demonstrates the noninferiority of medium-term quality of life of one group in relation to the other(XEN~? implant and trabeculectomy). The number of topical anti-hypertensive drugs and IOP negatively influenced the quality of life. | Ana Luisa Basilio Nuno Moura-Coelho Ines Passos Mariana Sa Cardoso Isabel Domingues Maria Reina Rita Flores Teresa Gomes | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 0 |
| 6 | Management Accounting Practices in the Portuguese Lodging Industry显示文摘 | Luis Lima Santos Conceicao Gomes Nuno Arroteia | 2012 | Journal of Modern Accounting and Auditing2012，8，1： | 0 |
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