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| 1 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 2 | Hepatitis B virus reactivation with a rituximab-containing regimen显示文摘Rituximab is currently used not only in the treatment of B-cell lymphoma but also for various other diseases, including autoimmune diseases, post-transplant graft vs host disease, and rejection following kidney transplants. Due to rituximab's widespread use, great progress has been made regarding research into complications that arise from its use, one of the most serious being the reactivation of hepatitis B virus(HBV), and efforts continue to establish guidelines for preventive treatment against this occurrence. This report discusses preventive measures against rituximab-induced HBV reactivation and future objectives. | Yutaka Tsutsumi Yoshiya Yamamoto Shinichi Ito Hiroyuki Ohigashi Souichi Shiratori Hirohito Naruse Takanori Teshima | 2015 | World Journal of Hepatology2015，7，21： | 5 |
| 3 | Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer显示文摘 | Hidenori Takahashi Hiroaki Ohigashi Kunihito Gotoh Shigeru Marubashi Terumasa Yamada Masayuki Murata Tatsuya Ioka Hiroyuki Uehara Masahiko Yano Osamu Ishikawa | 2013 | Annals of Surgery2013，，6： | 3 |
| 4 | Delayed perforation: A hazardous complication of endoscopic resection for non‐ampullary duodenal neoplasm显示文摘 | Takuya Inoue Noriya Uedo Takeshi Yamashina Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Ryu Ishihara Hiroyasu Iishi Masaharu Tatsuta Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi | 2014 | Digestive Endoscopy2014，，2： | 3 |
| 5 | Successful embolization assisted by covered stents for a pseudoaneurysm following pancreatic surgery显示文摘Delayed intra-abdominal hemorrhage after pancreatic surgery is a potentially lethal complication.Transarterial coil embolization and/or the placing of an endovascular stent are minimally invasive and effective procedures.An artery that is extensively eroded and rendered friable due to operative skeletonization or postoperative inflammation sometimes contributes to delayed intra-abdominal hemorrhage or rebleeding after coil embolization.This report presents a case of successful management of postoperative hemorrhage in a-74-year-old Japanese male.He experienced bleeding from a pseudoaneurysm of the brittle hepatic artery following total pancreatectomy.Initially the pseudoaneurysm was successfully treated with covered coronary stent-grafts,but rebleeding occurred 1 mo later due to the brittleness of the artery.Rebleeding was definitively managed by the complete packing of the stent by coil embolization.He remains stable at 18 mo following the f inal embolization.A stent graft can be used for protecting a brittle artery to avoid injury by coil embolization. | Koji Tanaka Hiroaki Ohigashi Hidenori Takahashi Kunihito Gotoh Terumasa Yamada Isao Miyashiro Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 2 |
| 6 | CD74 Is a Novel Prognostic Factor for Patients with Pancreatic Cancer Receiving Multimodal Therapy显示文摘 | Shigenori Nagata Yu-Fen Jin Katsuhiko Yoshizato Miki Tomoeda Misa Song Norishige Iizuka Masanori Kitamura Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi Osamu Ishikawa Yasuhiko Tomita | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 7 | Application of sentinel node biopsy to gastric cancer surgery显示文摘 | Masahiro Hiratsuka Isao Miyashiro Osamu Ishikawa Hiroshi Furukawa Kazuyoshi Motomura Hiroaki Ohigashi Masao Kameyama Yo Sasaki Toshiyuki Kabuto Shingo Ishiguro Shingi Imaoka Hiroki Koyama | 2001 | Surgery2001，，3： | 2 |
| 8 | Removal of competitive native species combined with tree planting can accelerate the initial afforestation process: an experiment in an old field in Japan invaded by dwarf bamboo and kudzu显示文摘Restoring natural forests after field abandonment is a land management objective that fosters the recovery of forest biodiversity. We performed seeding and transplanting of native tree species 40 years after the abandonment of an arable field that became dominated by a dwarf bamboo(Pleioblastus chino(Franch. et Sav.)Makino) and by kudzu(Pueraria lobata(Willd.) Ohwi).By permutation tests, the removal of competing vegetation(gap creation) significantly increased the survival of three seeded species of Fagaceae and of eight transplanted species. In contrast, intact vegetation prevented most individuals of all species from surviving for 1 year after planting. The lack of natural recruitment of Fagaceae in the nonseeded subplots indicated that seed limitation was a cause of the slow afforestation. Although litter accumulation in gaps at the time of seeding slightly increased survival for late-germinating Quercus myrsinifolia Blume and Castanopsis sieboldii(Makino) Hatus. ex T. Yamaz. et Mashiba, the effect was not consistent among plots and was not statistically significant. Our results suggest that for successful afforestation using native trees in abandoned fields, it will be necessary to remove competitive native species to avoid severe limitations on microsite availability and that simultaneous tree establishment by seeding or transplanting should be implemented to accelerate the establishment of native tree species. | Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi Yamaguchi Takahiro Ara Nobukazu Nakagoshi | 2015 | Journal of Forestry Research2015，26，3： | 2 |
| 9 | Comparison of bio- markers for predicting disease severity and long - term respiratory prognosis in patients with acute pulmonary embolism显示文摘 | Ohigashi H Haraguchi G Yoshikawa S | 2010 | Int Heart J2010，51，6： | 1 |
| 10 | Formation and stabili-zation model of the 42 - mer A beta radical : Implications for thelong - lasting oxidative stress in Alzheimer's disease显示文摘 | Murakami K Ohigashi H Nagao M | 2005 | Journal ofthe american chemical society2005，127，15： | 1 |
| 11 | Coronary artery spatialdistribution,morphology, and composition of nonculprJt coronary plaques by 64-s;fce computed tomographic angiography in patiets with acute myocardial infarction显示文摘 | Sato A Ohigashi H Nozato T | 2010 | Am J Oardiol2010，105，7： | 1 |
| 12 | Tyrosine kinase inhibitors reduce bcl-2 expression and induce apoptosis in androgen-dependent cells显示文摘 | Ohigashi T Ueno M Nonaka S Nakanoma T Furukawa Y Deguchi N | 2000 | Am J Physiol Cell Physiol2000，278，： | 1 |
| 13 | A catechol antioxidantprotocatechuic acid potentiates inflammatory leukocyte-derivedoxidative stress in mouse skin via a tyrosinase bioactivation path-way显示文摘 | Nakamura Y Torikai k Ohigashi H | 2001 | Free Radic Biol Med2001，30，9： | 1 |
| 14 | Jpn Appl J Phys显示文摘 | Ohigashi H and Koga K | 1982 | 21:L455-L4571982，21，： | 1 |
| 15 | Citrus an- raptene targets translation of MMP-7 (matrilysin) via ERK 1/2-de- pendent and mTOR-independent mechanism显示文摘 | Kyuichi Kawabata Akira Murakami Hajime Ohigashi | 2006 | FEBS Lett2006，580，： | 1 |
| 16 | Practical grouping of positive lymph nodes in pancreatic head cancer treated by an ex- tended pancreatectomy 显示文摘 | Ishikawa O Ohigashi H Sasaki Y | 1997 | Surgery1997，121，3： | 1 |
| 17 | Vessel wall inflammation of Takayasu arteritis detect ed by contrast-enhanced magnetic resonance imaging:Association with disease distribution and activity显示文摘 | Kato Y Terashima M Ohigashi H | 2015 | Plo S One2015，10，01： | 1 |
| 18 | Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism 显示文摘 | Kyuichi Kawabata Akira Murakami Hajime Ohigashi | 2006 | FEBS Letters2006，580，： | 1 |
| 19 | Reciprocal functions of liver tumor cells and endothelial cells : involvement of endothelial cell migration and tumor proliferation at a primary site in distant metastasis显示文摘 | Okamoto H Ohigashi H Nakamori S | 2000 | Eur Surg Res2000，32，6： | 1 |
| 20 | Real-Time Intraoperative Assessment of Residual Liver Functional Reserve Using Pulse Dye Densitometry显示文摘 | Hirofumi Akita Yo Sasaki Terumasa Yamada Kunihito Gotoh Hiroaki Ohigashi Hidetoshi Eguchi Masahiko Yano Osamu Ishikawa Shingi Imaoka | 2008 | World Journal of Surgery2008，，12： | 1 |
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