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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Comparison of practical methods for urinary glycosaminoglycans and serum hyaluronan w ith clinical activity scores in patients w ith Grave’s ophthalmopathy显示文摘 | Martins JR Furlanetto RP Oliveira LM Mendes A Passerotti CC Chiamolera MI | 2004 | Clin Endocrinol2004，60，6： | 1 |
| 3 | Cxcl8 (IL-8)mediates neutrophil recruitment and behavior in the zebrafishinflammatory response 显示文摘 | de Oliveira S Reyes-Aldasoro CC Candel S | 2013 | J Immunol2013，190，8： | 1 |
| 4 | Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling显示文摘 | Valentini SR Casolari JM Oliveira CC | 2002 | Genetics2002，160，2： | 1 |
| 5 | HOXAI0 controls proliferation, migralion and inwision in oral sqtlalnOLiS cell carcinoma显示文摘 | Carrera M Bitu CC de Oliveira CE | 2015 | Int J Clin Exp Palho12015，8，4： | 1 |
| 6 | Clonal nature of odontogenic tumours 显示文摘 | Gomes CC Oliveira Cda S Castro WH | 2009 | J Oral Pathol Med2009，38，4： | 1 |
| 7 | The other Janus face of Qa- 1 and HLA-E: diverse peptide repertoires in times of stress显示文摘 | Van HT Oliveira CC Joosten SA | 2010 | Microbes Infect2010，12，12： | 1 |
| 8 | Frequency of extra-colonic tumors in hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) Brazilian families:An analysis by a Brazilian Hereditary Colorectal Cancer Institutional Registry显示文摘 | Oliveira FF Napoli-Ferreira CC Rossi BM | 2004 | Fam Cancer2004，3，1： | 1 |
| 9 | Genetic interactions of yeast eukaryotic translation initiation factor 5A ( eIF5A ) reveal connections to poly ( A ) -binding protein and protein kinase C signaling 显示文摘 | VALENTINI SR CASOLARI JM OLIVEIRA CC | 2002 | Genetlcs2002，160，2： | 1 |
| 10 | Polysaccharides from peach pulp: structure and effects on mouse peritoneal macrophages 显示文摘 | Simas-Tosin FF Abud AP De Oliveira CC | 2012 | Food Chem2012，134，4： | 1 |
| 11 | PON1 M/L55 mutation protects high-risk patients against coronaryartery disease显示文摘 | Oliveira SA Mansur AP Ribeiro CC | 2004 | Int J Cardiol2004，94，1： | 1 |
| 12 | Detrimental effect of blood pressure reduction in the first 24 hours of acute stroke onset显示文摘 | Oliveira - FilhoJ Silva SC Trabuco CC | 2003 | Neurology2003，61，8： | 1 |
| 13 | Evaluation of gati-floxacin penetration into skeletal muscle and lung by microdi-alysis in rats显示文摘 | Tasso L Bettoni CC Oliveira LK | 2008 | Int J Pharm2008，358，12： | 1 |
| 14 | Proteins binding to 5'untranslated region sites : a general mechanism for translational regulation of mRNAs in human and yeast cells显示文摘 | Stripecke R Oliveira CC McCarthy JE | 1994 | Mol Cell Biol1994，14，9： | 1 |
| 15 | Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD 显示文摘 | Borghi-Silva A Oliveira CC Carrascosa CR Maia J Berton DC Queiroga F Jr | 2008 | Thorax2008，63，10： | 1 |
| 16 | Mer- curius solubilis: Actions on macrophages显示文摘 | de Oliveira SM de Oliveira CC Abud AP | 2011 | Homeopathy2011，100，4： | 1 |
| 17 | Bioelectrical impedance and visceral fat:a comparison with computed tomography in adults and elderly显示文摘 | Eickemberg M Oliveira CC Roriz AK | 2013 | Arq Bras Endocrinol Metabol2013，57，1： | 1 |
| 18 | Detrimental effect of blood Pressure reduction in the first 24 hours of acute onset显示文摘 | Oliveira Filho J silva SC Trabuco CC | 2003 | Neurology2003，61，8： | 1 |
| 19 | Properties and in vivo investigation of nanocrystalline hydroxyapatite obtained by mechani- cal alloying显示文摘 | Silva CC Pinheiro AG De Oliveira RS | 2004 | Mater Sci Eng C2004，24，4： | 1 |
| 20 | Evaluation of gati- floxacin penetration into skeletal muscle and lung by microdial- ysis in rats显示文摘 | Tasso L Bettoni CC Oliveira LK | 2008 | Int J Pharm2008，358，12： | 1 |
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