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| 1 | Overweight and obesity in hip and knee arthroplasty:Evaluation of 6078 cases显示文摘AIM: To evaluate a possible association between thevarious levels of obesity and peri-operative characteristics of the procedure in patients who underwent endoprosthetic joint replacement in hip and knee joints. METHODS: We hypothesized that obese patients were treated for later stage of osteoarthritis, that more conservative implants were used, and the intraand perioperative complications increased for such patients. We evaluated all patients with body mass index(BMI) ≥ 25 who were treated in our institution from January 2011 to September 2013 for a primary total hip arthroplasty(THA) or total knee arthroplasty(TKA). Patients were split up by the levels of obesity according to the classification of the World Health Organization. Average age at the time of primary arthroplasty, preoperative Harris Hip Score(HHS), Hospital for Special Surgery score(HSS), gender, type of implanted prosthesis, and intra-and postoperative complications were evaluated.RESULTS: Six thousand and seventy-eight patients with a BMI ≥ 25 were treated with a primary THA or TKA. Age decreased significantly(P < 0.001) by increasing obesity in both the THA and TKA. HHS and HSS were at significantly lower levels at the time of treatment in the super-obese population(P < 0.001). Distribution patterns of the type of endoprostheses used changed with an increasing BMI. Peri- and postoperative complications were similar in form and quantity to those of the normal population. CONCLUSION: Higher BMI leads to endoprosthetic treatment in younger age, which is carried out at significantly lower levels of preoperative joint function. | Daniel Guenther Stefan Schmidl Till O Klatte Harald K Widhalm Mohamed Omar Christian Krettek Thorsten Gehrke Daniel Kendoff Carl Haasper | 2015 | World Journal of Orthopedics2015，6，1： | 4 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 4 | Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa显示文摘 | Kuniholm Mark H Lesi Olufunmilayo A Mendy Maimuna Akano Aliu O Sam Omar Hall Andrew J Whittle Hilton Bah Ebrima Goedert James J Hainaut Pierre Kirk Gregory D | 2008 | Environmental Health Perspectives2008，，11： | 2 |
| 5 | Synthesis and Invitro Antimicrobial and Antifungul Properties of Some Novel 1,3,4-thiadiazole and s-triazolethiadiazole显示文摘 | Omar A M E Aboulwafa O M | 1986 | Heterocycl Chem1986，23，： | 1 |
| 6 | Systematic design of pore size and functionality in isoreticular MOFs and their application in methane storage显示文摘 | Eddaoudi Mohamed Kim Jaheon Rosi Nathaniel Vodak David Wachter Joseph O'Keeffe Michael Yaghi Omar M | 2002 | Science2002，295，： | 1 |
| 7 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks显示文摘 | Sung Park Kyo Ni Zheng Cete Adrien P Choi Jae Yong Huang Rudan Uribe-Romo Femando J Chae Hee K O'Keeffe Michael Yaghi Omar M | 2006 | Proceedings of the National Academy of Sciences2006，103，10： | 1 |
| 8 | Autonomous over- head crane system using a fuzzy logic controller 显示文摘 | OMAR F KARRAY F BASIR O | 2004 | Jour- nal of Vibration and Control2004，，10： | 1 |
| 9 | Effects of metsulfur on methyl on amylase, urease and protease activities in two soils显示文摘 | lsmail B S Yapp K F Omar O | 2000 | Aust J SoilRes2000，，36： | 1 |
| 10 | Effect of CAD-CAM porcelain veneers thickness on their cemented color 显示文摘 | Omar H Atta O E1-Mowafy O | 2010 | J Dent2010，382，： | 1 |
| 11 | Large-scale simulation of elastic wave propagation in heterogeneous media on parallel computers显示文摘 | Hesheng Bao Jacobo Bielak Omar Ghattas Loukas F. Kallivokas David R. O’Hallaron Jonathan R. Shewchuk Jifeng Xu | 1998 | Computer Methods in Applied Mechanics and Engineering1998，，1： | 1 |
| 12 | Thyroid disorders in pregnancy : frequency and association with selected diseases and obstetrical complications in Tunisian women 显示文摘 | Feki M Omar S Menif O | 2008 | Clin Biochem2008，41，12： | 1 |
| 13 | Reticular synthesis and the design of new materials显示文摘 | Yaghi Omar M O'Keeffe Michael Ockwig Nathan W Chae Hee K Eddaoudi Mohamed Kim Jaheon | 2003 | Nature2003，423，： | 1 |
| 14 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O’Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 15 | Isoreticular expansion of metal-organic frameworks with triangular and square building units and the lowest calculated density for porous crystals显示文摘 | Furukawa Hiroyasu Bok Go Yong Ko Nakeun Park Young Kwan Uribe-Romo Femando J Kim Jahenn O'Keeffe Michael Yaghi Omar M | 2011 | Inorganic Chemistry2011，50，： | 1 |
| 16 | Synthesis and in vitro antimicrobial and antifungal properties of some novel 1,3,4-thiadiazole and s-triazolothiadiazole derivatives显示文摘 | Omar A Mohsen M E Aboulwafa O M | 1986 | J Heterocycl Chem1986，23，： | 1 |
| 17 | The influence of bone type on the gene expression in normal bone and at the bone-implant interface: experiments in animal model显示文摘 | Omar O Suska F Lenneras M | 2011 | Clin Implant Dent Relat Res2011，13，2： | 1 |
| 18 | Synergism of cellulase enzymes in mixed culture solid substrate fermentation 显示文摘 | Massadeh M I Yusoff W M W Omar O | 2001 | Biotechnology Letters2001，23，21： | 1 |
| 19 | Thyroid disorders in pregnancy: frequency and as- sociation with selected diseases and ob- stetrical complications in Tunisian women显示文摘 | Feki M Omar S Menif O el al | 2008 | Clin Biochem2008，41，12： | 1 |
| 20 | Synthesis and anticonvulsant properties of a novel series of 2-( substituted amino)-5-aryl-1, 3,4-oxadiazole derivatives 显示文摘 | Omar A Mohsen M E Aboulwafa O M | 1984 | J Heterocycl Chem1984，21，5： | 1 |
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