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| 1 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 2 | Congenital diarrhea in a newborn infant: A case report显示文摘BACKGROUND Microvillus inclusion disease(MVID)is a rare autosomal recessive cause of severe congenital diarrhea with significant morbidity and mortality.Definitive treatment involves bowel transplant.The diagnosis of this condition can be challenging and a few genetic panels are available for the identification of the most common mutations.We present the case of an infant with MVID due to a mutation not reported in the literature before.CASE SUMMARY We report the case of an infant transferred to our institution with severe diarrhea of unknown etiology,failure to thrive,and significant metabolic derangements.An extensive work-up including stool studies for common gastrointestinal pathogens,abdominal ultrasound,esophagogastroduodenoscopy with duodenal biopsy and flexible sigmoidoscopy failed to reveal a diagnosis.Multiple dietary and formula regimens were introduced but all resulted in voluminous diarrhea.She remained on total parenteral nutrition(TPN)for the duration of her hospital stay.Genetic testing was done and she was subsequently found to have a novel mutation in the MYO5B gene[homozygous mutation for MYO5B c.1462del,p.(Ile488Leufs*93)]giving us the diagnosis of MVID.She remains on TPN while awaiting bowel transplant at the time of the compilation of this case report.CONCLUSION We report a novel mutation involved in MVID and highlight the importance of considering this disease when faced with a newborn presenting with life threatening diarrhea.At the time of this publication,232 allelic variations of this gene(MIM#606540)exist in National Center for Biotechnology Information’s database.Our patient’s mutation has not been reported in literature as a cause of MVID. | Mehrin Sadiq Omer Choudry Arun K Kashyap Danitza M Velazquez | 2019 | World Journal of Clinical Pediatrics2019，8，3： | 3 |
| 3 | Antimicrobial Agents from Selected Medicinal Plants in Libya显示文摘Objective:To test the in vitro antimicrobial efficacy of water and methanol extracts of 23 plan species that are commonly used in Libyan folk medicine.Methods:The antimicrobial activity was determinec using the well-diffusion method.Four test microorganisms were used namely,Escherichia coli,Salmonella species,Staphylococcus aureus and Bacillus subtilis.The minimum inhibitory concentration(MIC) was determined for the high biologically active crude plant extracts.Results:Among 23 medicinal plants used in the study,only 5 methanolic extracts[Rosmarinus offcinalis L,Carduus marianium L.,Lantana camara L.,Rhus tripartite(ueria) Grande,and Thymus capitatus(L.) Hoffm(link)]showed the highest antimicrobial activity againsl Staphylococcus aureus,Bacillus subtilis and Salmonella species,while 22 methanolic and aqueous extracts showed moderate to weak antimicrobial activity on all tested organisms.However 19 of the extracts showed no activity at all against Gram-ve and Gram +ve microorganisms.MIC was found to be 1.25 mg/mL(Thymus capitatus),3 mg/mL(Rhus tripartite),4 mg/mL(Carduus marianium),5 mg/mL(Rosamarinus officinalis) and5 mg/mL(Lantana camara),respectively.Conclnsions:The present results revealed that,crude methanolic extracts of the investigated Libyan folk medicinal plants exhibited mild to high in vitro antibacterial activities against Gram-positive and Gram-negative microorganisms. | Hasan MH Muhaisen Miftah Mailoud Ab-Mous Fadel A Ddeeb Aboclaid All Rtemi Omer M Taba Mehtab Parveen | 2016 | Chinese Journal of Integrative Medicine2016，22，3： | 2 |
| 4 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
| 5 | Sweet potato whitefly resistance to insecticides in Hawaii:intra-island variation is related to insecticide use显示文摘 | OMER A D JOHNSON M W TABASHNIK B E | 1993 | Entomol Exp Appl1993，67，2： | 1 |
| 6 | Green Energies and the Environment 显示文摘 | Omer A M | 2008 | Renewable and Sustainable Energy Reviews2008，12，7： | 1 |
| 7 | MiRNA based mechanism for the commitment of multipotent progenitors to a single cellular fate显示文摘 | Mati M Omer B Reuven A | 2010 | PNAS2010，107，15： | 1 |
| 8 | A chaotic masking scheme by using synchronized chaotic systems显示文摘 | OMER M MOEZ F | 1999 | Physics Letters A1999，251，： | 1 |
| 9 | Reduction of COD in wastewater from an organized tannery industrial region by electro -Fenton process显示文摘 | Ugur Kurt Omer Apaydin M Talha Gonullu | 2007 | Journal of Hazardous Materials2007，143，： | 1 |
| 10 | Color lines:image specific color representation显示文摘 | Omer I Werman M | | 0，，06： | 1 |
| 11 | Functionalised ZnO-nanorod-based selective electrochemi- cal sensor for intracellular glucose 显示文摘 | Muhammad H Asif Syed M Usman Ali Omer Nur | 2010 | Biosens Bioelec- tro2010，25，： | 1 |
| 12 | Inhibition of farnesyl-transferase induces regression of mammary and salivary carcinomas in ras transgenic mice显示文摘 | Kohl N E Omer CA Conner M W | 1995 | Nat Med1995，1，8： | 1 |
| 13 | Dissolved organic carbon (DOC) as a parameter of compost maturity显示文摘 | Sharon Z N Omer M Jorge T | 2005 | Soil Biology & Biochemistry2005，，37： | 1 |
| 14 | Colloidal silver nanoparticles stailized by a water- soluble triosmium cluster显示文摘 | Omer M Ahmed E Leong W K | 2006 | Journal of Organometallic Chemistry2006，691，5： | 1 |
| 15 | Microbiological food safety assessment of high hydrostatic pressure processing: A review显示文摘 | Rendueles E Omer M K Alvseike O | 2011 | LWT-Food Science and Technology2011，44，： | 1 |
| 16 | Electrochemistry and electrogenerated chemiluminescence of quinoxaline derivatives 显示文摘 | IZADYAR A OMER K M LIU Y | 2008 | J Phys Chem C2008，112，20： | 1 |
| 17 | Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease显示文摘 | Omer Z Cetinkalp S Akyildiz M | | 0，，01： | 1 |
| 18 | The effect of par- tially cut - out blanks on geometric accuracy in incremental sheet forming 显示文摘 | Julian M Allwood Daniel Braun Omer music | 2010 | Journal of Material Processing Technology2010，210，： | 1 |
| 19 | Genetic and environmental influences on susceptibility to acephate in sweetpotato whitefly ( Homoptera: Aleyrodidae) 显示文摘 | OMER A D TABASHNIK B E JOHNSON M W | 1993 | J Econ Entomol1993，86，3： | 1 |
| 20 | Fracture mechanisms of offset rock joints-A laboratory investigation显示文摘 | OMER M ABDEL K U | 2004 | Geotechnical and Geological Engineering2004，22，： | 1 |
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