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| 1 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 2 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 3 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 4 | Peripherally inserted centralcatheters and upper extremity deep vein thrombosis 显示文摘 | Ong B Gibbs H Catchpole I | 2006 | Australas Radiol2006，50，： | 1 |
| 5 | A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling显示文摘 | Blagoev B Kratchmarova I Ong SE | 2003 | Nat Biotechnol2003，21，： | 1 |
| 6 | Vena caval transection during retroperioneo copic nephrectomy: report of the complication and review of the literature显示文摘 | McAllister M Bhayani S B Ong A | 2004 | J Urol2004，172，： | 1 |
| 7 | Optimal planar evasive aircraft maneuvers against proportional navigation missiles 显示文摘 | Ong S Y Pierson B L | 1996 | Journal of Guidance Control and Dynamics1996，19，6： | 1 |
| 8 | Effect of cadmium and cigarette smoking on human sperm quality显示文摘 | Chi SE Xu B Ong CN | 1994 | Int J Fertil Menopausal Stud1994，39，5： | 1 |
| 9 | RUNX3 acts as a tumor sup- pressor in breast cancer by targeting estrogen receptor alpha 显示文摘 | Huang B Qu Z Ong C W | 2012 | Oncogene2012，31，4： | 1 |
| 10 | Automated high-performance liquid chromatographic method with pre-column reduction for the determination of ubiquinol and ubiquinone plasma 显示文摘 | WANG Q LEE B L ONG C N | 1999 | J Chromatogr B1999，726，： | 1 |
| 11 | Peripherally Inserted Central Catheters and Upper Extremity Deep Vein Thrombosis显示文摘 | Ong B Gibbs H Catchpole I | 2006 | Australas Radiol2006，50，5： | 1 |
| 12 | Orientation characterization and photoconductive properties of ethylenediamine bridged silicon phthalocyanine polymer thin film显示文摘 | SIM J H ONG B S REED C A | 1996 | Thin Solid Films1996，40，2： | 1 |
| 13 | An occlusal and eephalometric analysis of maxillary first and second premolar extraction effects 显示文摘 | Ong H B Woods M G | 2001 | Angle Orthod2001，71，2： | 1 |
| 14 | Archaeal dominance in the mesopelagic zone of the Pacific Ocean显示文摘 | KARNER M B DEI ONG E F KARL D M | 2001 | Nature2001，409，： | 1 |
| 15 | Genetic diversity within a range of cultivars and landraces of flax as revealed by RAPDs显示文摘 | Ong B Axel D Richards K | 2002 | Genetic Resources and Crop Volution2002，49，2： | 1 |
| 16 | Antimicrobial resistance in non- typhoidal Salmonellas from humans in Northern Ireland, 2001-2003: standardization needed for better epidemiological monitoring 显示文摘 | Ong G Wilson I Smyth B | 2007 | Epidemiol Infet2007，135，4： | 1 |
| 17 | Activation of TRPC1 by STIM1 in ER-PM micredomains involves release of the channel from its scaf- fold caveolin-l显示文摘 | Pani B Ong H L Brazer S C | 2009 | Proc Natl Acad Sci U S A2009，106，20： | 1 |
| 18 | The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury显示文摘 | Ong S B Samangouei P Kalkhoran S B | 2015 | J Mol Cell Cardiol2015，78，： | 1 |
| 19 | Space variant image processing显示文摘 | WALLACE R ONG P BEDERSON B | 1995 | International Journal of Computer Vision1995，13，1： | 1 |
| 20 | Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics显示文摘 | Blagoev B Ong S E Kratchmarova I | 2004 | Nat Biotechnol2004，22，： | 1 |
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