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| 1 | Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis显示文摘AIM To evaluate the prognostic value of site-specific metastases among patients with metastatic pancreaticc arcinoma registered within the Surveillance, Epidemiology and End Results(SEER) database.METHODS SEER database(2010-2013) has been queried through SEER*Stat program to determine the presentation, treatment outcomes and prognostic outcomes of metastatic pancreatic adenocarcinoma according to the site of metastasis. In this study, metastatic pancreatic adenocarcinoma patients were classified according to the site of metastases(liver, lung, bone, brain and distant lymph nodes). We utilized chi-square test to compare the clinicopathological characteristics among different sites of metastases. We used Kaplan-Meier analysis and log-rank testing for survival comparisons. We employed Cox proportional model to perform multivariate analyses of the patient population; and accordingly hazard ratios with corresponding 95%CI were generated. Statistical significance was considered if a two-tailed P value < 0.05 was achieved. RESULTS A total of 13233 patients with stage Ⅳ pancreatic cancer and known sites of distant metastases were identified in the period from 2010-2013 and they were included into the current analysis. Patients with isolated distant nodal involvement or lung metastases have better overall and pancreatic cancer-specific survival compared to patients with isolated liver metastases(for overall survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001)(for pancreatic cancer-specific survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001). Multivariate analysis revealed that age < 65 years, white race, being married, female gender; surgery to the primary tumor and surgery to the metastatic disease were associated with better overall survival and pancreatic cancer-specific survival.CONCLUSION Pancreatic adenocarcinoma patients with isolated liver metastases have worse outcomes compared to patients with isolated lung or distant nodal metastases. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease. | Hani Oweira Ulf Petrausch Daniel Helbling Jan Schmidt Meinrad Mannhart Arianeb Mehrabi Othmar Schob Anwar Giryes Michael Decker Omar Abdel-Rahman | 2017 | World Journal of Gastroenterology2017，23，10： | 13 |
| 2 | 中国和欧洲家庭的家务分工:文化的视角(英文)显示文摘本文通过对以往研究的总结,讨论了哪些因素可以帮助理解中国和欧洲家庭之间的家务分工文化差异。首先,我们将中国家庭的家务分工状况与欧洲家务的情况进行了对比,总结了文化差异所在。其次,我们分析了目前家务分工研究领域内的主要理论模型在中国社会里的应用情况。我们发现,这些模型只能部分的解释,为什么中国和欧洲家庭在家务分工上存在文化差异。接下来,我们讨论了儒家思想和第三方的家务承担对于夫妻家务分工可能产生的影响,以扩展家务分工跨文化研究的理论框架。最后,我们总结了文化价值观和家务支持对于理解不同文化中的夫妻家务分工的意义,呼吁更多的研究关注。 | 王志云 Dominik Schoebi Meinrad Perrez | 2010 | 心理科学进展2010，18，10： | 4 |
| 3 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 4 | Small-bowel MRI in children and young adults with Crohn disease: retrospective head-to-head comparison of contrast-enhanced and diffusion-weighted MRI显示文摘 | Henning Neubauer Thomas Pabst Anke Dick Wolfram Machann Laura Evangelista Clemens Wirth Herbert K?stler Dietbert Hahn Meinrad Beer | 2013 | Pediatric Radiology2013，，1： | 2 |
| 5 | Impact of cardiac magnet resonance imaging on management of ventricular septal rupture after acute myocardial infarction显示文摘A 74-year-old man was admitted to the cardiac catheterization laboratory with acute myocardial infarction. After successful angioplasty and stent implantation into the right coronary artery, he developed cardiogenic shock the following day. Echocardiography showed ventricular septal rupture. Cardiac magnet resonance imaging (MRI) was performed on the critically ill patient and provided detailed information on size and localization of the ruptured septum by the use of fast MRI sequences. Moreover, the MRI revealed that the ventricular septal rupture was within the myocardial infarction area, which was substantially larger than the rupture. As the patient's condition worsened, he was intubated and had intra-aortic balloon pump implanted, and extracorporeal membrane oxygenation was initiated. During the following days, the patient's situation improved, and surgical correction of the ventricular septal defect could successfully be performed. To the best of our knowledge, this case report is the first description of postinfarction ventricular septal rupture by the use of cardiac MRI in an intensive care patient with cardiogenic shock and subsequent successful surgical repair. | Tobias Gassenmaier Armin Gorski Ivan Aleksic Nikolas Deubner Frank Weidemann Meinrad Beer | 2013 | World Journal of Cardiology2013，5，5： | 2 |
| 6 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 7 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 8 | Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium 显示文摘 | Meinrad Gawaz | 2004 | Circulation research2004，61，： | 1 |
| 9 | A Randomized Trial of Prasugrel Versus Clopidogrel in Patients With High Platelet Reactivity on Clopidogrel After Elective Percutaneous Coronary Intervention With Implantation of Drug-Eluting Stents显示文摘 | Dietmar Trenk Gregg W. Stone Meinrad Gawaz Adnan Kastrati Dominick J. Angiolillo Ulrike Müller Gert Richardt Joseph A. Jakubowski Franz-Josef Neumann | 2012 | Journal of the American College of Cardiology2012，，24： | 1 |
| 10 | Free breathing cardiac real-time cine MR without ECG triggering显示文摘 | Meinrad Beer Heimo Stamm Wolfram Machann Andreas Weng Jan P. Goltz Frank Breunig Frank Weidemann Dietbert Hahn Herbert K?stler | 2010 | International Journal of Cardiology2010，，2： | 1 |
| 11 | In situ mRNA hybridization analysis and immunolocalization of the vitamin D receptor in normal and carcinomatous human colonic mucosa: relation to epidermal growth factor receptor expression显示文摘 | Yuri Sheinin Klaus Kaserer Friedrich Wrba Etienne Wenzl Stefan Kriwanek Meinrad Peterlik Heide S. Cross | 2000 | Virchows Archiv2000，，5： | 1 |
| 12 | Transcriptional Control of Early B Cell Development <sup>1</sup>显示文摘 | Meinrad Busslinger | 2004 | Annual Review of Immunology2004，，： | 1 |
| 13 | Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells显示文摘 | MEINRAD G JOSEF N TIMM D | 1998 | Circulation1998，98，12： | 1 |
| 14 | Prevalence and predictors of severe autonomic failure in patients with insulin-dependent type 2 diabetes mellitus and coronary artery disease: pilot study显示文摘 | Christine S. Zuern Konstantinos Rizas Christian Eick Katharina Sterz Meinrad Gawaz Axel Bauer | 2012 | Journal of Electrocardiology2012，，6： | 1 |
| 15 | 血小板膜糖蛋白Ⅵ:一种新的急性冠状动脉综合征生物学指标显示文摘目前研究认为,血小板膜糖蛋白Ⅵ在动脉血栓形成方面发挥关键作用。用流式细胞技术测定血小板活性标志蛋白如血小板选择素(P-selectin)、血小板膜GPIbα(CD42b)和血小板膜糖蛋白Ⅵ的表达,发现患有急性冠状动脉综合征的患者,其血小板膜糖蛋白Ⅵ表达比稳定型心绞痛患者和健康人有明显的提高,且其表达量与P-selectin正相关。血小板膜糖蛋白Ⅵ高表达水平往往与急性冠状动脉综合征的心肌坏死因子如肌钙蛋白和肌酸激酶相关。同时发现,在急性冠状动脉综合征的患者中,血小板膜糖蛋白Ⅵ的表达比肌钙蛋白和肌酸激酶这些心肌受损的指标提早数小时。因此认为,血小板膜糖蛋白Ⅵ可作为心肌梗死患者的潜在性危险程度指标。 | Boris Bigalke 李忠民 Meinrad Gawaz 陈乃耀 | 2011 | 心血管病学进展2011，32，5： | 1 |
| 16 | Plate let activation and coronary stent implantation显示文摘 | Franz JN Dka O | 1996 | Circulation1996，94，： | 1 |
| 17 | Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model显示文摘 | Lutz W. D. Weber Meinrad Boll Andreas Stampfl | 2003 | CRC Critical Reviews in Toxicology2003，，2： | 1 |
| 18 | Platelet Function in Acute myocardial infarction Treated with Direct Augioplasty显示文摘 | Meinrad G Franz-Josef N Ilka O | 1996 | Circulationt1996，93，： | 1 |
| 19 | Treatment of inoperable tracheobronchial obstructive lesions with the Palmaz stent显示文摘 | Meinrad Beer Güenther Wittenberg J?ern Sandstede Matthias Beissert Michael Schmidt J?erg Ender Thomas Krahe Dietbert Hahn | 1999 | CardioVascular and Interventional Radiology1999，，2： | 1 |
| 20 | Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model显示文摘 | Lutz W. D. Weber Meinrad Boll Andreas Stampfl | 2003 | CRC Critical Reviews in Toxicology2003，，2： | 1 |
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