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| 1 | Immune checkpoint inhibitors for treatment of advanced gastric or gastroesophageal junction cancer:Current evidence and future perspectives显示文摘Despite the application of conventional therapies,the prognosis of advanced gastric cancer(GC)or gastroesophageal junction cancer(GEJC)is still poor.In recent years,immune checkpoint inhibitors(ICIs)have reshaped the paradigm of cancer therapy.Emerging evidence support the feasibility of programmed cell death-1(PD-1)and its ligand(PD-L1)inhibition in chemo-refractory GC/GEJC.Nivolumab and pembrolizumab have initially been approved in Japan and United States,respectively for the third-line treatment of progressive GC or GEJC.In March 2020,nivolumab has also been licensed in China for treating advanced GC/GEJC who received≥2 lines of systemic therapies.Current studies are moving forward to the first-line application or focusing on combination strategies,though data are insufficient and disputable.In this review,we summarize the recently reported and ongoing clinical trials in ICIs for advanced GC/GEJC.Molecular characteristics and clinical implications of different tumor subtypes are also reviewed.We further discuss the safety profile and biomarkers for predicting the response of ICIs,which has guiding values in clinical practice. | Zhening Zhang T ong Xie Xiaotian Zhang Changsong Qi Lin Shen Zhi Peng | 2020 | Chinese Journal of Cancer Research2020，32，3： | 10 |
| 2 | Season of the year influences infection rates following total hip arthroplasty显示文摘AIM To research the influence of season of the year on periprosthetic joint infections.METHODS We conducted a retrospective review of the entire Medicare files from 2005 to 2014. Seasons were classified as spring, summer, fall or winter. Regional variations were accounted for by dividing patients into four geographic regions as per the United States Census Bureau(Northeast, Midwest, West and South). Acute postoperative infection and deep periprosthetic infections within 90 d after surgery were tracked. RESULTS In all regions, winter had the highest incidence of periprosthetic infections(mean 0.98%, SD 0.1%) and was significantly higher than other seasons in the Midwest, South and West(P < 0.05 for all) but not the Northeast(P = 0.358). Acute postoperative infection rates were more frequent in the summer and were significantly affected by season of the year in the West.CONCLUSION Season of the year is a risk factor for periprosthetic joint infection following total hip arthroplasty(THA). Understanding the influence of season on outcomes following THA is essential when risk-stratifying patients to optimize outcomes and reduce episode of care costs. | Samuel Rosas Alvin C Ong Leonard T Buller Karim G Sabeh Tsun yee Law Martin W Roche Victor H Hernandez | 2017 | World Journal of Orthopedics2017，8，12： | 4 |
| 3 | Hepatitis B infection among adults in the philippines:A national seroprevalence study显示文摘AIM:To determine the prevalence of hepatitis B surface antigen(HBsAg)seropositivity among adult Filipinos.METHODS:Testing for HBsAg was performed on serum samples from persons aged ≥ 20 years old who participated in the National Nutrition and Health Survey(NNHeS)conducted in 2003.Information on age,sex,marital status,educational attainment,employment status,and income were collected.For this study,marital status was classified as never married or otherwise(i.e.,married,divorced,separated,widowed);educational attainment was classified as high school graduate or below or at least some tertiary education;and employment status was classified as currently employed or currently unemployed.Annual income was divided into 4 quartiles in Philippine pesos(PhP):Q1,≤ PhP 53064;Q2,PhP 53065-92192;Q3,PhP 92193-173387;and Q4,≥ PhP 173388.Prevalence estimates were weighted so that they represented the general population.Social and demographic factors were correlated with HBsAg seropositivity.Multivariate analysis was used to determine independent predictors of HBsAg seropositivity.RESULTS:A total of 2150 randomly selected adults,20 years and over,out of the 4753 adult participants of NNHeS were tested for HBsAg.The HBsAg seroprevalence was 16.7%(95%CI:14.3%-19.1%),which corresponded to an estimated 7278968 persons infected with hepatitis B.There was no significant difference between males and females(17.5% vs 16.0%;P = 0.555).This corresponded to an estimated 3721775 men and 3557193 women infected with hepatitis B.The HBsAg seroprevalence peaked at age 20-39 years old,with declining prevalence in the older age groups.The only independent predictor of HBsAg seropositivity was the annual income,with persons in the highest income quartile being less likely to be HBsAg positive(age-adjusted OR = 0.51;95%CI:0.30-0.86)compared to subjects in the lowest income quartile.Sex,marital status,educational attainment,and employment status were not found to be independent predictors of HBsAg seropositivity.CONCLUSION:The high HBsAg seroprevalence among adults in the Philippines classifies the country as hyperendemic for HBV infection and appears unchanged over the last few decades. | Stephen N Wong Janus P Ong Madalinee Eternity D Labio Oscar T Cabahug Maria Lourdes O Daez Erlinda V Valdellon Jose D Sollano Jr Marilyn O Arguillas | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 4 | 重新审视β受体阻滞剂在高血压及心血管疾病中的地位显示文摘β受体阻滞剂可降低心肌梗死后的死亡率,并改善收缩性心力衰竭患者的预后;可减少高风险患者手术前治疗的不良事件;在较年轻的患者中(60岁以下),β受体阻滞剂的疗效与其它抗高血压药物相似;β受体阻滞剂可能改善冠心病的预后,并延缓疾病的进展;在预防高血压患者的心血管事件方面,阿替洛尔的疗效可能不如其它β受体阻滞剂以及其它抗高血压药物。 | H T Ong 张海燕(编译) | 2007 | 中国处方药2007，6，6： | 2 |
| 5 | Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore显示文摘Background Emergency medical services(EMS)is a critical link in the chain of stroke survival.We aimed to assess EMS use for stroke in Singapore,identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and treatment.Methods The Singapore Stroke Registry combines nationwide EMS and public hospital data for stroke cases in Singapore.Multivariate regressions with the generalised estimating equations were performed to examine the association between EMS use and timely stroke evaluation and treatment.results Of 3555 acute ischaemic patients with symptom onset within 24 hours admitted to all five public hospitals between 2015 and 2016,68%arrived via EMS.Patients who used EMS were older,were less likely to be female,had higher stroke severity by National Institute of Health Stroke Scale and had a higher prevalence of atrial fibrillation or peripheral arterial disease.Patients transported by EMS were more likely to receive rapid evaluation(door-to imaging time≤25 min 34.3%vs 11.1%,OR=2.74(95%CI 1.40 to 5.38))and were more likely to receive intravenous tissue plasminogen activator(tPA,22.8%vs 4.6%,OR=4.61(95%CI 3.52 to 6.03)).Among patients treated with tPA,patients who arrived via EMS were more likely to receive timely treatment than self-transported patients(door-to needle time≤60 min 52.6%vs 29.4%,OR=2.58(95%CI 1.35 to 4.92)).Conclusions EMS use is associated with timely stroke evaluation and treatment in Singapore.Seamless EMS-Hospital stroke pathways and targeted public campaigns to advocate for appropriate EMS use have the potential to improve acute stroke care. | Hanzhang Xu Ying Xian Fung Peng Woon Janet Prvu Bettger Daniel T Laskowitz Yih Yng Ng Marcus Eng Hock Ong David Bruce Matchar Deidre Anne De Silva | 2020 | Stroke & Vascular Neurology2020，5，2： | 2 |
| 6 | Ferrocement laminates for strengthening RC T- beams 显示文摘 | Paramasivam P Ong K C G Lim C T E | 1994 | Cement and Concrete Composites1994，16，2： | 1 |
| 7 | Wet-pavement hydroplaning risk and skid resistance:modeling显示文摘 | Ong G P Fwa T F | | 0，，10： | 1 |
| 8 | Synthesis, characterization and comparative study of nano- Ag--TiO2 against Gram- positive and Gram- negative bacteria under fluorescent light 显示文摘 | BARUDIN N H A SREEKANTAN S ONG M T | 2014 | Food Control2014，，46： | 1 |
| 9 | Thirty-day incidence and sixmonth clinical outcome of thrombotic stent occlusion after baremetal, sirolimus, or paclitaxel stent implantation 显示文摘 | Ong A T Hoye A Aoki J | 2005 | J Am Coll Cardiol2005，45，6： | 1 |
| 10 | Flexural Strengthening of Reinforced Concrete Beams Using Ferrocement Laminate 显示文摘 | Ong K C G Paramasivam Lim C T E | 1992 | Journal of Ferrocement1992，，： | 1 |
| 11 | Double-skinned forward osmosis membranes for reducing internal concentration po- larization within the porous sublayer显示文摘 | Wang K Y Ong R C Chung T S | 2010 | Industrial and En- gineering Chemistry Research2010，49，10： | 1 |
| 12 | A Study on Ar- senic Removal from Household Drinking Water 显示文摘 | Yuan T Luo Q-F Hu J-Y Ong S-L Ng W-J | 2003 | Journal of Environmental Seience and Health Part A2003，38，9： | 1 |
| 13 | Laparosc0pic pyeloplasty: current status显示文摘 | Inagaki T Rha K H Ong A M | 2005 | BJU international2005，95，2： | 1 |
| 14 | Local Ca2 en- try via Orail regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca2 signals required for specific cell functions 显示文摘 | CHENG K T LIU X ONG H L | 2011 | PLoS Biol2011，9，10： | 1 |
| 15 | Dependence of the exeitonie transition energies and mosaicity on residual strain in ZnO thin films显示文摘 | Ong H C Zhu A X E Du G T | | 0，，： | 1 |
| 16 | A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region显示文摘 | Png E Thalamuthu A Ong R T | 2011 | Hum Mol Genet2011，20，19： | 1 |
| 17 | Analysis of step-lifetest data:a new approach 显示文摘 | Sun YS Goh T N Ong H L | 1996 | IEEE Transactions on Reliability1996，45，1： | 1 |
| 18 | Circadian rhythm in cardiac arrest:the Singapore experience显示文摘 | LATEEF F ONG M E ALFRED T | 2008 | Singapore Med J2008，49，9： | 1 |
| 19 | Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme(GBM)显示文摘 | Yin D Zhou H Kumagai T Liu G Ong JM Black KL | 2005 | Oncogene2005，24，3： | 1 |
| 20 | Late angiographic stent thrombosis (LAST) events with drug-eluting stents显示文摘 | ONG A T L MCFADDEN E P REGAR E | 2005 | J Am Coll Cardiol2005，45，： | 1 |
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