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| 1 | Management of occult hepatitis B virus infection:An update for the clinician显示文摘Occult hepatitis B virus(HBV) infection(OBI) is defined by the presence of HBV DNA in the liver tissue of individuals who test negative for hepatitis B surface antigen(HBsAg).Patients who have recovered from acute hepatitis B can carry HBV genomes for a long time and show histological patterns of mild necro-inflammation,even fibrosis,years after the resolution of acute hepatitis,without showing any clinical or biochemical evidence of liver disease.At least in conditions of immunocompetence,OBI is inoffensive itself,but when other relevant causes of liver damage are present it might make the course of the liver disease worse.The risk of HBV transmission through transfusion is related to blood donations negative for HBsAg that have been collected during the pre-seroconversion period or during chronic OBI.Use of HBV nucleic acid amplification testing and multivalent anti-HBs antibodies in the HBsAg assays is recommended for detection of true and false OBI,respectively.It is not known if prior hepatitis B immunization with an optimal anti-HBs response in cases of HBV transmission through organ transplantation can effectively modulate or abort the infection.Use of anti-viral agents as prophylaxis in patients with serological evidence of past HBV infection prevents reactivation of OBI after transplantation in most cases.Reactivation of OBI has been observed in other conditions that cause immunosuppression,in which antiviral therapy could be delayed until the HBV DNA or HBsAg becomes detectable.OBI might contribute to the progression of liver fibrosis and hepatocellular carcinoma development in patients with chronic liver disease. | JoséLuis Lledó Conrado Fernández María Luisa Gutiérrez Sara Ocaa | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Identification of Lynch syndrome: How should we proceed in the 21^(st) century?显示文摘Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years. | Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 4 | A Unified Ant Colony Optimization Algorithm for Continuous Optimiza- tion 显示文摘 | LIAO T STUTZLE T de Oca M A M | 2014 | European Journal of Operational Research2014，234，3： | 1 |
| 5 | Supercritical fluid extraction and fractionation of different preprocessed rosemary plants显示文摘 | Ibanez E Oca A Murga G De | 1999 | J Agric Food Chem1999，47，： | 1 |
| 6 | Magnesi-um inhibits Wnt/p-catenin activity and reverses the osteogenictransformation of vascular smooth muscle cells 显示文摘 | Montes de Oca A Guerrero F Martinez-Moreno JM | 2014 | PLoS One2014，9，89： | 1 |
| 7 | Snail blocks the cell cycle and confers resistance to cell death显示文摘 | Vega S Morales AV Oca(n)a OH Valdés F Fabregat I Nieto MA | | 0，，10： | 1 |
| 8 | Adenovirus respiratory tract infections in Peru显示文摘 | Ampuero JS Oca?a V Gómez J | 2012 | PLoS One2012，7，46： | 1 |
| 9 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 10 | Antibiotic susceptibility of potentially probiotic vaginal lactobscilli 显示文摘 | Oca a V Silva C Nader-Mac as ME | 2006 | Infectious Diseases in Obstetrics and Gyneoology2006，，： | 1 |
| 11 | Cork taint of wines: role of the filamentousfungi isolated from cork in the formation of 2,4,6-trichloroanisoleby o-methylation of 2, 4,6- trichlorophenol显示文摘 | MARIA LUISA ALVAREZ-RODRIGUEZ LAURA LOPEZ- OCA A JOSE MIGUE1LOPEZ-CORONADO | 2002 | Applied Adenvironmental Microbiology2002，68，12： | 1 |
| 12 | High - phosphate - induced calcification is related to SM22a promoter methylation in vascular smooth muscle cells显示文摘 | MONTES DE OCA A MADUEO JA MARTINEZ - MORENO JM | 2010 | J Bone Miner Res2010，25，9： | 1 |
| 13 | Sublingual ranula:a closer look to its surgical management显示文摘 | Mortellaro C Dall'Oca S A Castiglia A | 2008 | J Craniofac Surg2008，19，1： | 1 |
| 14 | Significant improvement in normal tissue sparing and target coverage for head and neck cancer by means of helical tomotherapy显示文摘 | Fiorino C Dell'Oca I Pierelli A | 2006 | Radiother Oncol2006，78，3： | 1 |
| 15 | The identification of irradiated crustaceans and evaluation of the dose by thermoluminescence: Intercomparison between two methods for extracting minerals显示文摘 | D'Oca M C Bartolotta A | 2010 | Food Research International2010，43，： | 1 |
| 16 | The additive-dose method for dose estimation in irradiated oregano by thermoluminescence technique显示文摘 | D'Oca M C Bartolotta A Cammilleri M C Giuffrida S Parlato A Di Stefano V | 2009 | Food Control2009，20，： | 1 |
| 17 | Mangrove vegetation assessment in the Santiago River Mouth,Mexico,by means of supervised classification using Landsat TM imagery显示文摘 | RAMíREZ-GARCíA P L PEZ-BLANCO J OCA A D | 1998 | Forest Ecology and Management1998，105，1： | 1 |
| 18 | Predominance of mTORC1 over mTORC2 in the Regulation of Proliferation of Ovarian Cancer Cells: Therapeutic Implications显示文摘 | Juan Carlos Montero Xi Chen Alberto Oca?a Atanasio Pandiella | 2012 | Molecular Cancer Therapeutics2012，，6： | 1 |
| 19 | Frankenstein's PSO: A composite particle swarm optimization algorithm 显示文摘 | MONTES DE OCA M A STUTZLE T BIRATTARI M DORIGO M | 2009 | IEEE Transaction on Evolutionary Computation2009，13，5： | 1 |
| 20 | Trichinella spiralis:intranasal immunization with attenuated Salmonella enterica carrying a gp43 antigen-derived 30mer epitope elicits protection in BALB/c mice显示文摘 | Pompa-Mera EN Yépez-Mulia L Oca(n)a-Mondrag6n A | | 0，，04： | 1 |
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