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| 1 | Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis显示文摘AIM: To evaluate the effi cacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP). METHODS: We conducted a prospective study on patients who developed SAP with or without CRAI. Out of 18 patients fulf illed clinical diagnostic criteria for SAP in Japan, 9 patients underwent CRAI, while 9 patients underwent conventional systemic protease inhibitor and antibiotics therapy (non-CRAI). CRAI was initiated within 72 h of the onset of pancreatitis. Gabexate mesilate (2400 mg/d) was continuously administered for 3 to 5 d. The clinical outcome including serum infl ammation-related parameters were examined. RESULTS: The duration of abdominal pain in the CRAI group was 1.9 ± 0.26 d, whereas that in the non-CRAI group was 4.3 ± 0.50. The duration of SIRS in the CRAI group was 2.2 ± 0.22 d, whereas that in the non- CRAI group was 3.2 ± 0.28. Abdominal pain and SIRS disappeared signifi cantly in a short period of time after the initiation of CRAI using gabexate mesilate. The average length of hospitalization signifi cantly differed between the CRAI and non-CRAI groups, 53.3 ± 7.9 d and 87.4 ± 13.9 d, respectively. During the first two weeks, levels of serum CRP and the IL6/IL10 ratio in the CRAI group tended to have a rapid decrease compared to those in the non-CRAI group. CONCLUSION: The present results suggest that CRAI using gabexate mesilate was effective against SAP. | Yoshifumi Ino Yoshiyuki Arita Tetsuro Akashi Toshinari Kimura Hisato Igarashi Takamasa Oono Masayuki Furukawa Ken Kawabe Keiichiro Ogoshi Jiro Ouchi Toshihiko Miyahara Ryoichi Takayanagi Tetsuhide Ito | 2008 | World Journal of Gastroenterology2008，14，41： | 20 |
| 2 | Impact of endoscopic screening on mortality reduction from gastric cancer显示文摘AIM:To investigate mortality reduction from gastric cancer based on the results of endoscopic screening.METHODS:The study population consisted of participants of gastric cancer screening by endoscopy,regular radiography,and photofluorography at Niigata city in 2005.The observed numbers of cumulative deaths from gastric cancers and other cancers were accumulated by linkage with the Niigata Prefectural Cancer Registry.The standardized mortality ratio(SMR)of gastric cancer and other cancer deaths in each screening group was calculated by applying the mortality rate of the reference population.RESULTS:Based on the results calculated from the mortality rate of the population of Niigata city,the SMRs of gastric cancer death were 0.43(95%CI:0.30-0.57)for the endoscopic screening group,0.68(95%CI:0.55-0.79)for the regular radiographic screening group,and 0.85(95%CI:0.71-0.94)for the photofluorography screening group.The mortality reduction from gastric cancer was higher in the endoscopic screening group than in the regular radiographic screening group despite the nearly equal mortality rates of all cancers except gastric cancer.CONCLUSION:The 57%mortality reduction from gastric cancer might indicate the effectiveness of endoscopic screening for gastric cancer.Further studies and prudent interpretation of results are needed. | Chisato Hamashima Kazuei Ogoshi Rintarou Narisawa Tomoki Kishi Toshiyuki Kato Kazutaka Fujita Masatoshi Sano Satoshi Tsukioka | 2015 | World Journal of Gastroenterology2015，21，8： | 16 |
| 3 | Focus on the conditions of resection and reconstruction in gastric cancer.What extent of resection and what kind of reconstruction provide the best outcomes for gastric cancer patients显示文摘 | Ogoshi K Okamoto Y Nabeshima K | | 0，，： | 2 |
| 4 | Non-potable urban water reuse-a case of Japanese water recycling显示文摘 | Masashi Ogoshi Yutaka Suzuki | 2000 | Water2000，21，6： | 2 |
| 5 | Studies on the taxonomy of the genus Rhizoctonia显示文摘 | Ogoshi A | 1984 | Ann Phytopath Soc Japan1984，50，： | 1 |
| 6 | Thermal stor- age medium using a hydrate and apparatus thereof, and method for producing the thermal storage medium 显示文摘 | Takao S Ogoshi H Fukushima S | 2007 | United States Patent Application Publication2007，2，： | 1 |
| 7 | Organic–inorganic polymer hybrids prepared by the sol-gel method显示文摘 | Tomoki Ogoshi Yoshiki Chujo | 2005 | Composite Interfaces (-)2005，，8： | 1 |
| 8 | Autoimmune Pancreatitis as a New Clinical Entity (Three Cases of Autoimmune Pancreatitis with Effective Steroid Therapy)显示文摘 | Tetsuhide Ito Itsuro Nakano Shujiro Koyanagi Toshihiko Miyahara Yoshikatsu Migita Keiichiro Ogoshi Hironori Sakai Shizu Matsunaga Osamu Yasuda Toshihiko Sumii Hajime Nawata | 1997 | Digestive Diseases and Sciences1997，，7： | 1 |
| 9 | J Am Chem Soc显示文摘 | Kuroda Y Sera T Ogoshi H | 1991 | 113:2793-27941991，113，： | 1 |
| 10 | Detection of telomerase activity in malignant and nonmalignant skin conditions显示文摘 | Taylor RS Ramirez RD Ogoshi M | 1996 | J Invest Dermatol1996，106，4： | 1 |
| 11 | Ecology and pathogenicity of anastomosis and intraspecific groups of Rhizoctonia solani Kuhn 显示文摘 | Ogoshi A | 1987 | Annual Review of Phytopathology1987，25，1： | 1 |
| 12 | Identification of novel adrenomedullin in mammals:a potentcardiovascular and renal regulator显示文摘 | Inoue K Ogoshi M | 2004 | FEBS Lett2004，556，13： | 1 |
| 13 | Identification of novel adrenomedullin in mammals:a potent cardiovascular and renal regulator显示文摘 | Inoue K Ogoshi M | 2004 | FEBS Lett2004，556，： | 1 |
| 14 | Identification of a novel adrenomedullin gene family in teleost fish显示文摘 | Ogoshi M Inoue K Takei Y | 2003 | Biochem Biophys Res Commun2003，311，： | 1 |
| 15 | Heterogeneity of Ca^2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons:fluorescence imaging and immunocytochemical assessment显示文摘 | Ogoshi F Weiss J H | 2003 | J Neurosci2003，23，10： | 1 |
| 16 | Research history of Rhizoctonia and the diseases 显示文摘 | Ogoshi A | 1997 | Annals of the Phytopathological Society of Japan1997，63，3： | 1 |
| 17 | Ecology and pathogenicity of anastomosis and intraspecific groups of Rhizoctonia solani Kiilan显示文摘 | Ogoshi A | 1987 | Phytopathology1987，25，1： | 1 |
| 18 | Isoenzyme polymorphism and segregation in isolates Phytophthora infestarts from Japan 显示文摘 | MOSA A A KOBAYASHI K OGOSHI A | 1993 | Plant Pathology1993，42，： | 1 |
| 19 | In situ hybridization analysis of the expression of human telomerase RNA in normal and pathologic conditions of the skin显示文摘 | Ogoshi M Le T Shay JW | 1998 | J Invest Dermatol1998，110，5： | 1 |
| 20 | Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator显示文摘 | Takei Y Inoue K Ogoshi M | 2004 | FEBS Letters2004，556，： | 1 |
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