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| 1 | 响应面分析法优化超声辅助提取山楂中总黄酮的工艺显示文摘采用响应面分析法优化山楂中总黄酮超声辅助提取的工艺条件.以总黄酮(以金丝桃苷计)得率为指标,在单因素试验的基础上,应用了响应面中的Box-Benhnken模型设计试验,对提取工艺影响较大的山楂粉碎粒度、超声时间、料液比、超声功率4个工艺参数进行优化.结合实际操作,最佳的工艺条件为粉碎粒度40目,超声时间33min,料液比1∶33(g/mL),超声功率160W,在此条件下,总黄酮得率为5.21%,与预测值5.26%基本相符. | 邓泽丽 Oh Young Joo 李洪军 Tae Seok Kim 项怡 Ik Hyun Yeo 贺稚非 | 2014 | 西南大学学报(自然科学版)2014，36，8： | 11 |
| 2 | 响应面法优化金银花凉茶浸提工艺的研究显示文摘采用响应面分析法优化金银花凉茶的浸提工艺条件,以金银花、菊花、夏枯草和鱼腥草为原料,绿原酸得率为指标.在单因素试验基础上,应用Box-Benhnken中心组合设计试验,对浸提工艺影响较大的料液比、浸提时间、浸提温度3个工艺参数进行优化.结果表明:金银花等原料的绿原酸水提工艺的最佳条件为不粉碎原料、固定金银花1g,菊花、夏枯草和鱼腥草质量比为2∶2∶1共1.5g,料液比为1∶32,浸提时间为71min,浸提温度为78℃,浸提2次,在该条件下验证绿原酸得率达到3.01%,接近于预测值3.04%.研究表明,优化得到的回归模型具有良好的预测能力. | 陈康 Oh Young Joo 李洪军 Tae Seok Kim 贺稚非 Ik Hyun Yeo | 2014 | 西南大学学报(自然科学版)2014，36，12： | 9 |
| 3 | 金银花乳杆菌发酵凉茶的研制显示文摘该研究的目的在于探究植物乳杆菌发酵金银花凉茶的工艺条件。以金银花为原料,通过单因素试验和正交试验,研究植物乳杆菌PMO接种量、发酵温度、发酵时间和糖添加量对金银花凉茶发酵过程的影响,并对发酵工艺条件进行优化。结果表明,植物乳杆菌PMO经过驯化过程,其在金银花凉茶中具有优良的增殖活性;金银花凉茶中绿原酸含量受发酵过程影响较小,始终稳定在29.20 mg/g左右;金银花凉茶最佳发酵工艺条件为植物乳杆菌PMO接种量3%、发酵温度37℃、发酵时间14 h、糖添加量7%。 | 陈康 Oh Young Joo 李洪军 Tae Seok Kim 贺稚非 Ik Hyun Yeo | 2016 | 食品科学2016，37，3： | 8 |
| 4 | Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis显示文摘瞄准:在葡聚糖硫酸盐的发展调查淋巴细胞的角色导致钠的大肠炎。方法:用葡聚糖硫酸盐钠(决策支持系统)的各种各样的剂量,我们在野类型的 B6 控制和 Rag-1 大美人( H-2b haplotype )导致了大肠炎鼠标,并且评估了大肠炎以征兆并且 histologic 参数例如重量损失,幸存,腹泻的严厉,冒号长度和组织学的变化的缺乏。征兆的参数每天被检查,组织学的变化被获得。结果:尽管在 Rag-1 猛烈老鼠的大肠炎的开发与决策支持系统的高剂量(5%) 对待比得上在 B6 控制老鼠,大肠炎前进在 Rag-1 猛烈老鼠与相比是更可容忍的比在与低剂量(1.5%) 对待的 B6 老鼠决策支持系统。征兆的参数以及组织病理学说的变化在 Rag-1 猛烈鼠标被改进。结论:这些结果显示淋巴细胞的存在在决策支持系统刺激的低剂量贡献大肠炎前进。淋巴细胞可以在导致决策支持系统的大肠炎作为一个加重的因素起作用。 | Tae Woon Kim Jae Nam Seo Young Ho Suh Hyo Jin Park Ju Hyun Kim Ji Young Kim Kwon Ik Oh | 2006 | World Journal of Gastroenterology2006，12，2： | 6 |
| 5 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 6 | Successful treatment of multiple hepatocellular adenomas with percutaneous radiofrequency ablation显示文摘Hepatocellular adenoma(HCA)is one of the important complications of glycogen storage disease typeⅠa(GSD-Ⅰa)because it can be transformed into hepatocellular carcinoma.Although surgical resection is a standard treatment of choice for solitary HCA,multiple HCAs in GSD-Ⅰa patients present as therapeutic challenges for curative treatment.Therefore,treatment strategy according to malignant potential is important in management of HCAs in GSD-Ⅰa.The authors present a case of histologically proven multiple HCAs withoutβ-catenin mutations occurred in a GSD-Ⅰa patient treated successfully with percutaneous radiofrequency ablation as a minimally invasive therapy. | Sun Young Ahn Soo Young Park Young Oh Kweon Won Young Tak Han Ik Bae Seung Hyun Cho | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 7 | Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation显示文摘 | Min Kyu Jung Seong Woo Jeon Soo Young Park Chang Min Cho Won Young Tak Young Oh Kweon Sung Kook Kim Yong Hwan Choi Han Ik Bae | 2008 | Surgical Endoscopy2008，，12： | 3 |
| 8 | Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation显示文摘 | Min Kyu Jung Seong Woo Jeon Soo Young Park Chang Min Cho Won Young Tak Young Oh Kweon Sung Kook Kim Yong Hwan Choi Han Ik Bae | 2008 | Surgical Endoscopy2008，，12： | 3 |
| 9 | Factors affecting the technical difficulty of colonoscopy 显示文摘 | Oh SY Sohn CI Sung IK | 2007 | Hepatogastroenterology2007，54，3： | 1 |
| 10 | Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance显示文摘 | Moon MK Jeong IK Oh TJ | 2015 | J Endocrino2015，，： | 1 |
| 11 | Docetaxel(Taxotere),cisplatin,UFT,and leucovorin combination chemotherapy in advanced gastric cancer显示文摘 | Oh SC Park KH Choi IK | 2005 | British Journal of Cancer2005，92，5： | 1 |
| 12 | Intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic mac- ular edema 显示文摘 | Choi YJ Oh IK Oh JR | 2006 | Korean J Ophthalmol2006，20，： | 1 |
| 13 | Long-term visual outcome of arteriovenous adventitial sheathotomy on branch retinal vein occlusion induced macular edema 显示文摘 | Oh IK Kim S Oh J | 2008 | Korean J Ophthalmol2008，22，1： | 1 |
| 14 | Factors of fecting the technical difficulty of colonoseopy :Hepatogastro - enterology显示文摘 | Oh SY Sohn CI Sung IK et ol | 2007 | Hepatogas troent erology2007，54，77： | 1 |
| 15 | Oncolytic adenovirus expressing IL -23 and p35 elicits IFN -/and TNF -e -co -producing T cell-mediated antitumor immunity显示文摘 | CHOI IK LI Y OH E | 2013 | PLoS One2013，8，67： | 1 |
| 16 | The stimulatory effect of IL- ibeta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway 显示文摘 | Jeong IK Oh SH Chung JH | 2002 | Exp Mol Med2002，34，1： | 1 |
| 17 | Electrically assisted blanking using the electroplasticity of ultra-high strength metal alloys显示文摘 | Woong Kim Kyeong-Ho Yeom Nguyen Trung Thien Sung-Tae Hong Byung-Kwon Min Soo Ik Oh Moon-Jo Kim Heung Nam Han Hyun-Woo Lee | 2014 | CIRP Annals - Manufacturing Technology2014，，： | 1 |
| 18 | A follow-up study of condyle fracture in children显示文摘 | Choi J Oh N Kim IK | 2005 | Int J Oral Maxillofac Surg2005，34，8： | 1 |
| 19 | Acomparative study on the shortterm clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer显示文摘 | Kim HJ Lee IK Lee YS Kang WK Park JK Oh ST Kim JG Kim YH | 2009 | Surg Endosc2009，23，8： | 1 |
| 20 | A follow-up study of condyle fracture in children显示文摘 | Choi J Oh N Kim IK | 2005 | Int J Oral Maxillofac Surg2005，34，8： | 1 |
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