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| 1 | Endoscopic retrograde cholangiopancreatography during pregnancy without radiation显示文摘AIM: To present our experience with pregnant patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) without using radiation, and to evaluate the acceptability of this alternative therapeutic pathway for ERCP during pregnancy. METHODS: Between 2000 and 2008, six pregnant women underwent seven ERCP procedures. ERCP was performed under mild sedoanalgesia induced with pethidine HCl and midazolam. The bile duct was cannulated with a guidewire through the papilla. A catheter was slid over the guidewire and bile aspiration and/or visualization of the bile oozing around the guidewire was used to confirm correct cannulation. Following sphincterotomy, the bile duct was cleared by balloon sweeping. When indicated, stents were placed. Confirmation of successful biliary cannulation and stone extraction was made by laboratory, radiological and clinical improvement. Neither fluoroscopy nor spot radiography was used during the procedure. RESULTS: The mean age of the patients was 28 years (range, 21-33 years). The mean gestational age for the fetus was 23 wk (range, 14-34 wk). Five patients underwent ERCP because of choledocholithiasis and/orcholedocholithiasis-induced acute cholangitis. In one case, a stone was extracted after precut papillotomy with a needle-knife, since the stone was impacted. One patient had ERCP because of persistent biliary fistula after hepatic hydatid disease surgery. Following sphincterotomy, scoleces were removed from the common bile duct. Two weeks later, because of the absence of fistula closure, repeat ERCP was performed and a stent was placed. The fistula was closed after stent placement. Neither post-ERCP complications nor premature birth or abortion was seen. CONCLUSION: Non-radiation ERCP in experienced hands can be performed during pregnancy. Stent placement should be considered in cases for which complete common bile duct clearance is dubious because of a lack of visualization of the biliary tree. | Adem Akcakaya Orhan Veli Ozkan Ismail Okan Orhan Kocaman Mustafa Sahin | 2009 | World Journal of Gastroenterology2009，15，29： | 17 |
| 2 | Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets:A pilot study显示文摘AIM:To evaluate the efficacy of same-day bowel preparation with Senna alkaloids combined with bisacodyl tablets in routine colonoscopy procedures.METHODS:Between March and June 2013,a sameday bowel preparation was implemented in our endoscopy unit.The preparation consisted of a semi-liquid,fiber-free diet one day prior to the procedure,with two bisacodyl tablets after lunch and dinner,and 250 mL of Senna alkaloid with 1.5 L of drinking water at 6 am the day of the procedure.The quality control parameters of colonoscopy were evaluated and implemented according to the guidelines of the American Society for Gastrointestinal Endoscopy.The pre-procedure,duringprocedure and post-procedure patient data were collected and analyzed:(1) pre-procedure(age,gender,comorbid diseases,colonoscopy indications,complete lack of compliance with the bowel preparation protocol);(2) during-procedure(sedation dose,duration of colonoscopy,withdrawal time,cecal intubation rate,polyp detection rate,Boston Bowel Preparation Scores and presence of foam and clear liquid); and(3) postprocedure(visual analogue scale score,pain during the procedure,patient satisfaction and premature withdrawal due to the insufficient bowel preparation).RESULTS:A total of 75 patients were included in this study with a mean age of 54.64 ± 13.29 years; 53.3%(40/75) were female and 46.7%(35/75) were male.A complete lack of compliance with the bowel preparation protocol was seen in 6.7% of patients(5/75).The mean total duration of colonoscopy was 16.12 ± 6.51 min,and the mean withdrawal time was 8.89 ± 4.07 min.The cecal intubation rate was 93.8%(61/64) and the polyp detection rate was 40%(30/75).The mean Boston Bowel Preparation Score was 7.38 ± 1.81,with the following distribution:right colon,2.34 ± 0.89; transverse colon,2.52 ± 0.67; left colon,2.52 ± 0.63.The mean visual analogue scale score was 4.59 ± 1.57.Due to insufficient bowel preparation,seven patients(7/75; 9.3%) were asked to repeat the procedure.Of these,five patients had poor or modest compliance with the protocol,and two patients reported constipation.Premature withdrawal due to insufficient bowel preparation was 2.7%(2/75).The overall satisfaction with the protocol was 86.7%(65/75),with patients reporting they would prefer the same protocol in a repeat procedure.CONCLUSION:The same-day administration of Senna alkaloids appears to be a safe and effective bowel cleansing protocol for colonoscopy procedures. | Erdinc Yenidogan Ismail Okan Huseyin Ayhan Kayaoglu Gokhan Giray Akgul Mufit Sansal Servet Tali Zeki Ozsoy Mustafa Sahin | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 3 | Mechanical lithotripsy and/or stenting in management of difficult common bile duct stones显示文摘BACKGROUND:Mechanical lithotripsy and/or stent insertion is the alternative therapeutic approach in difficult endoscopic retrograde cholangiopancreatography (ERCP)case.This study was designed to investigate the appropriate treatment for extraction of bile duct stones in difficult cases of ERCP. METHODS:Between 2000 and 2008,744 ERCP procedures were performed in 592 patients with choledocholithiasis in our endoscopy unit.The demographic features,and clinical and laboratory findings were collected from a prospectively held database.Bile duct calculi were extracted by basket and/or balloon catheter following ERCP and sphincterotomy.Patients with retained stones were regarded as difficult cases.These patients were treated with mechanical lithotripsy and those with incomplete clearance of stones underwent stent placement. RESULTS:Two hundred and forty-five patients(41%) were male and 347(59%)were female with a mean age of 58 years(range 19-95 years).Stones were impacted in 27 patients(5%).Stone extraction was performed by basket and/or balloon catheter in 610 ERCP procedures,and lithotripsy was performed in 70 ERCP procedures.Forty- four patients underwent stent insertion,and 20 underwent stent replacement.Morbidity occurred in 39 patients (5%),with no mortality associated with the procedure.Hemorrhage occurred in 9 patients and basket impaction in 4.Mild pancreatitis and cholangitis developed in 12 and 11 patients,respectively. CONCLUSION:Difficult cases of bile duct stones can be treated successfully with lithotripsy,and a stent should be applied when the common bile duct cannot be cleared completely. | Adem Akcakaya Orhan Veli Ozkan Gurhan Bas Atilla Karakelleoglu Orhan Kocaman Ismail Okan Mustafa Sahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 5 |
| 4 | Hepatic cystic echinococcosis:Percutaneous treatment as an outpatient procedure显示文摘Objective:To demonstrate utility and safety of the puncture aspiration injection and reospiration(PAIR)technique for outpatients.Methods:Percutaneous treatment with US guidance was applied to 33 patients for 44 cysts.Patients treated with the PAIR technique,were outpatients.PAIR and catheterization technique were evaluated for efficacy and safety of procedure and complication rates.Results:Thirty-five of 44 cysts were treated with the PAIR and 9 of 44 were treated with the catheterization technique.The success rate of the cysts Gharbi type 1(CEI)and type 2(Ct3a)treated with the PAIR technique was 1009.hi the follow up of 9 cysts treated with the catheterization technique,2 of them(22%)developed cyst infection and 1(11%)developed a biliary fistula.Conclusions:The PAIR technique was found to be an effective and safe approach in order to treat Gharbi type 1 and type 2 cysts percutaneously for outpatients.It has a very low complication rate in comparison with the catheterization technique.So every effort should be mode to finish the treatment with PAIR technique. | Mert Kroglu Bekir Erol Cemil Gürses Baris Türkbey Cem Yunus Bas Ahmet Sükrü Alparslan Banu Kale Kroglu Iclal Erdem Toslak Bülent eki Okan Akhan | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，3： | 4 |
| 5 | Triorchidism: a rare genital abnormality显示文摘 | Orcun Celik Salih Budak Ozgur Cakmak Huseyin Tarhan Okan Nabi Yalbuzdag Aziz Peker Yusuf Ozlem Ilbey | 2014 | Asian Journal of Andrology2014，16，6： | 4 |
| 6 | Associations between Vaspin Levels and Coronary Artery Disease显示文摘The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers.Although adipokine concentrations have been shown to be increased signifi cantly in atherosclerotic lesions,the role adipokines in the atherosclerotic process remains to be elucidated.Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity.Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease.Vascular infl ammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation.Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio.The therapeutic goal concerning vaspin is to fi ght atherosclerosis and related diseases,as well as to maintain vascular health. | Lutfu Askin Okan Tanriverdi Hakan Tibilli Serdar Turkmen | 2020 | Cardiovascular Innovations and Applications2020，，1： | 3 |
| 7 | Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus显示文摘Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the fi rst case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management. | Gokhan Okan Serpil Yaylaci Onder Peker Sabahattin Kaymakoglu Murat Saruc | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 8 | An artificial neural network approach for prediction of long-term strength properties of steel fiber reinforced concrete containing fly ash显示文摘In this study, an artificial neural network (ANN) model for studying the strength properties of steel fiber reinforced concrete (SFRC) containing fly ash was devised. The mixtures were prepared with 0 wt%, 15 wt%, and 30 wt% of fly ash, at 0 vol.%, 0.5 vol.%, 1.0 vol.% and 1.5 vol.% of fiber, respectively. After being cured under the standard conditions for 7, 28, 90 and 365 d, the specimens of each mixture were tested to determine the corresponding compressive and flexural strengths. The pa- rameters such as the amounts of cement, fly ash replacement, sand, gravel, steel fiber, and the age of samples were selected as input variables, while the compressive and flexural strengths of the concrete were chosen as the output variables. The back propagation learning algorithm with three different variants, namely the Levenberg-Marquardt (LM), scaled conjugate gradient (SCG) and Fletcher-Powell conjugate gradient (CGF) algorithms were used in the network so that the best approach can be found. The results obtained from the model and the experiments were compared, and it was found that the suitable algorithm is the LM algorithm. Furthermore, the analysis of variance (ANOVA) method was used to determine how importantly the experimental parameters affect the strength of these mixtures. | Okan KARAHAN Harun TANYILDIZI Cengiz D. ATIS | 2008 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2008，9，11： | 3 |
| 9 | The Role of Moisture Balance in Wound Healing显示文摘 | Denis Okan Kevin Woo Elizabeth A. Ayello Gary Sibbald | 2007 | Advances in Skin & Wound Care2007，，1： | 2 |
| 10 | Numerical simulation of rock cutting using the discrete element method显示文摘 | Okan Su Nuri Ali Akcin | 2010 | International Journal of Rock Mechanics and Mining Sciences2010，，3： | 2 |
| 11 | Effects of honey as a scolicidal agent on the hepatobiliary system显示文摘AIM: To examine the effects of 10% diluted honey, which has been shown to be scolicidal, on the liver and biliary system and determine whether it could be used as a scolicidal agent in the presence of biliary-cystic communication. METHODS: Thirty Wistar-Albino rats were divided into two groups. Honey with 10% dilution in the study group and 0.9% saline (NaCl) in the control group were injected into the common bile ducts of rats through a 3-mm duodenotomy. The animals were sacrificed 6 mo after the procedure. Histopathological, biochemical, and radiological examinations were performed for evaluation of side effects. RESULTS: At the end of the sixth month, liver function tests were found to be normal in both groups. The tissue samples of liver and ductus choledochus of the honey group showed no histomorphologic difference from the control group. No stricture on the biliary tree was detected on the retrograde cholangiograms. CONCLUSION: According to these results, we concluded that 10% diluted honey could be used as scolicidal agent safely in the presence of biliary-cystic communication. | Bulent Kilicoglu Kemal Kismet Sibel Serin Kilicoglu Serap Erel Omur Gencay Kadriye Sorkun Esra Erdemli Okan Akhan Mehmet Ali Akkus Iskender Sayek | 2008 | World Journal of Gastroenterology2008，14，13： | 2 |
| 12 | The diagnostic value of non-invasive tests for the evaluation of liver fibrosis in chronic hepatitis B patients显示文摘 | Serpil Erdogan Halef Okan Dogan Sevilay Sezer Sema Uysal Esra Ozhamam Serra Kayacetin Yuksel Koca | 2013 | Scandinavian Journal of Clinical & Laboratory Investigation2013，，4： | 2 |
| 13 | Clinical outcomes of a new diffractive multifocal intraocular lens显示文摘AIM:To evaluate clinical outcomes after implantation of a new diffractive aspheric multifocal intraocular lens(IOL) with +3.00 addition power.METHODS:This is a retrospective,consecutive case series of cataract patients who underwent bilateral implantation of the Optiflex MO/HF D012(Moss Vision Inc.Ltd,London,UK) multifocal IOL.Patients followed for 6 mo were included in the study.Data on distance,intermediate and near visual acuity,refractive error [manifest spherical equivalent(MSE)],contrast sensitivity,adverse events,subjective symptoms,spectacle independence and patient satisfaction [visual function questionnaire(VFQ)-25 questionnaire] were retrieved from electronic medical records and analyzed.RESULTS:Forty eyes of 20 patients with a mean age of 66.7±8.5 y(range:53-82) were included in the study.Mean uncorrected distance,near and intermediate visual acuity remained stable through postoperative visits and was 0.19±0.19 log MAR,Jaeger 4 and Jaeger 3 respectively at the 6 mo visit.At the end of postoperative 6 mo,MSE was-0.14±0.42 diopters(D) and 98% of the eyes were within 1.00 D of target refraction.Postoperative low contrast(10%) visual acuity remained stable(P=0.54) through follow up visits with a mean of 0.35±0.17 log MAR at the 6 mo visit.There were no reported adverse events.None of the patients reported subjective symptoms of halo or glare.Spectacle independence rate was 90%.Mean VFQ-25 questionnaire score was 93.5±6.12.CONCLUSION:The Optiflex MO/HF-DO12 IOL was safely implanted and successfully restored distance,intermediate and near visual acuity without impairing contrast sensitivity.High levels of spectacle independence were achieved at all distances including intermediate distance. | Baha Toygar Ozge Yabas Kiziloglu Okan Toygar Ali Murat Hacimustafaoglu | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 2 |
| 14 | Comprehensive analysis of pulsed plasma nitriding preconditions on the fatigue behavior of AISI 304 austenitic stainless steel显示文摘This study aims to draw an exact boundary for microstructural and mechanical behaviors in terms of pulsed plasma nitriding conditions.The pulsed plasma nitriding treatment was applied to AISI 304 austenitic stainless steel at different temperatures and durations.Results reveal that nitriding depth increased as process temperature and duration increase.The nitriding depth remarkably increased at 475℃for 8 h and at 550℃for 4 h.An austenite structure was transformed into a metastable nitrogen-oversaturated body-centered tetragonal expanded austenite(S-phase)during low-temperature plasma nitriding.The S-phase was converted to CrN precipitation at 475℃for 8 h and at 550℃for 4 h.Surface hardness and fatigue limit increased through plasma nitriding regardless of process conditions.The best surface hardness and fatigue limit were obtained at 550℃for 4 h because of the occurrence of CrN precipitation. | Okan Unal Erfan Maleki Remzi Varol | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 15 | The role of moisture balance in wound healing显示文摘 | Okan D Woo K Ayello EA | 2007 | Adv Skin Wound Care2007，20，1： | 1 |
| 16 | Use of Fenton oxidation to improve the biodegradability of a pharmaceutical wastewater显示文摘 | Huseyin Tekin Okan Bilkay Selale S Ataberk et ol | 2006 | Hazardous Materials2006，136，2： | 1 |
| 17 | Finite element analysis of stress relaxation in soft denture liner显示文摘 | Sato Y ABE Y Okane H | 2000 | J Oral Rehabil2000，27，： | 1 |
| 18 | Diagnostic value of MRCP in biliary pancreatitis : result of long - term follow - up 显示文摘 | OKAN I BAS G SAHIN M | 2012 | Acta Chit Belg2012，112，5： | 1 |
| 19 | Phase selection during solidification ofperitectic alloys显示文摘 | Umeda T Okane T Kurtz W | 1996 | Acta Mater1996，44，： | 1 |
| 20 | Pseudolithiasis due to ceftriaxone treatment for meningitis in children:report of 8 cases显示文摘 | Araz N Okan V Demirci M | | 0，，3： | 1 |
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