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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial det'ects显示文摘 | Jason R Dudas BA Kacey G | 2006 | J Ann Plast Surg2006，56，5： | 1 |
| 4 | Lipase production by yeasts from extra virgin olive oil显示文摘 | Ciafardini G Zullo BA Iride A | 2006 | Food Microbiology2006，23，： | 1 |
| 5 | Diagnostic value of CEA, CYFRA21 - 1 ,NSE and CAl25 assay in serum and pleural effusion of patients with lung cancer显示文摘 | WU G P BA J ZHAO Y J | 2007 | Acta Cytd2007，51，4： | 1 |
| 6 | Risk factors for HIV infectionamong men who have sex with men显示文摘 | Koblin BA Husnik MJ Colfax G | 2006 | AIDS2006，20，： | 1 |
| 7 | Survival of arteriove- nous fistulas and Shunts for hemodialysis显示文摘 | Burger H Kluchert BA Kootstra G | 1995 | Eur J surg1995，161，3： | 1 |
| 8 | The psychological context of quality of life:a psychometric analysis of a novel idiographic measure of bladder cancer patients'persional goals and concerns prior to surgery显示文摘 | Morganstern BA Bochner B Dalbagni G | 2011 | Health and Quality of Life Outcomes2011，15，09： | 1 |
| 9 | Recent advances in the understan- ding of Langerhans cell histiocytosis显示文摘 | Badalian-Very G Vergilio JA Degar BA | 2012 | Br J Haematol2012，156，2： | 1 |
| 10 | Muiticentric Castleman's disease 显示文摘 | Peterson BA Frizzera G | 1993 | Semin Oncol1993，20，6： | 1 |
| 11 | New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxin显示文摘 | McClane BA Chakrabarti G | 2004 | Anaerobe2004，10，2： | 1 |
| 12 | Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3显示文摘 | Apte BA Pepper MS Voest E Montesano R Olsen B Murphy G | 1997 | Invest Ophthalmol Vis Sci1997，38，： | 1 |
| 13 | Binding of a new opiate antagonist,nalmefene,to rat brain membranes显示文摘 | MICHEL ME BOLGER G WEISSMAN BA | 1984 | Pharmacologist1984，26，： | 1 |
| 14 | MRI patterns in orbital malignant lymphoma and atypical lymphocytic infiltrates显示文摘 | Akansel G Hendrix L Erickson BA | 2005 | Eur J Radiol2005，53，2： | 1 |
| 15 | Restricted immune responses lead to CNS demyelination and axonal damage显示文摘 | Mancardi G Hart BA Capello E | 2000 | J Neuroimmunol2000，107，2： | 1 |
| 16 | Comparison of the effects of fixed and removable functional appliances on the skeletal and dentoalveolar structures显示文摘 | Bilgi F Hamamci O Ba saran G | 2011 | Aust Orthod J2011，27，2： | 1 |
| 17 | Effect of rosgitazone on spontaneous and clomiphene citrate-induced ovulation in wowen with polycystic ovary syndrome显示文摘 | Ghina G William HK Michael BA | 2003 | Fertil Steril2003，79，3： | 1 |
| 18 | Contempovery management of patients with lelf rentricular systolic dysfunction,results from the spice reqistry显示文摘 | Brat BA Eitl G Held P | | 0，，： | 1 |
| 19 | ZW10 links mitotic checkpoint signaling to the structure kinetochare显示文摘 | Kops G J Kim Y Weaver BA | 2005 | Cell Biol2005，169，1： | 1 |
| 20 | Effect of long-acting nifedilpine on mortality and cardiovascular mortality in patients with symptomatic stable angina and hypertension:the ACTION trial显示文摘 | Lubsen J Wagener G Kirwan BA | 2005 | J Hypertens2005，23，： | 1 |
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