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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Differentia- tion between superficial and deep lobe parotid tumors by magnetic resonance imaging: usefulness of the parotid duct criterion显示文摘 | Imaizumi A Kuribayashi A Okochi K | 2009 | Acta Radiol2009，50，7： | 1 |
| 3 | Elevated levels of PDGF alpha receptors in keliod fibroblasts contribute to an enhanced response to PDGF显示文摘 | HAISA M OKOCHI H GROTENDORST GR | 1994 | J Invest Dermatol1994，103，： | 1 |
| 4 | Comparative study of two preparation methods of w/o/w emulsions: stirring and membrane emulsification 显示文摘 | Okochi H Nakano M | 1997 | Chem Pharm Bull1997，45，8： | 1 |
| 5 | Comparative study of two preparation methods of w/o/w emulsions:stirring and membrane emulsification 显示文摘 | Okochi H Nakano M | 1997 | Chem Pharm Bull1997，45，8： | 1 |
| 6 | Elevated levels of PDGF alpha receptors in keloid fibroblasts contribute to an enhanced response to PDGF显示文摘 | Haisa M Okochi H Grotendorst GR | 1994 | J Invest Dermatol1994，103，4： | 1 |
| 7 | lnterleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells 显示文摘 | Harashima A Toraya T Okochi A | 2009 | Mol Immunol2009，46，16： | 1 |
| 8 | 5' - Secretase associated with lipid rafts: multiple interactive pathways in the stepwise pro- cessing of 13 - carboxyl - terminal fragment 显示文摘 | Matsumura N Takami M Okochi M | 2014 | J Biol Chem2014，289，8： | 1 |
| 9 | Elevated levels of PDGF alpha receptors in keloid fibroblasts contribute to an enhanced response to PDGF 显示文摘 | HAISA M OKOCHI H GROTENDORST G R | 1994 | J Invest Dermatol1994，103，4： | 1 |
| 10 | Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair显示文摘 | IGARASHI A OKOCHI H BRADHAM D M | 1993 | Mol Biol Cell 41993，4，6： | 1 |
| 11 | On the existence of anti-periodic solutions to a nonlinear evolution equations associated with differential operators显示文摘 | Okochi H | 1990 | J Funct Anal1990，，91： | 1 |
| 12 | On the existence of periodic so-lutions to nonlinear abstract parabolic equations显示文摘 | Okochi H | 1988 | J Math1988，40，3： | 1 |
| 13 | Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair显示文摘 | Igarashi A Okochi H Bradham DM | 1993 | Mol Biol Cell1993，4，6： | 1 |
| 14 | A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene显示文摘 | Okochi H Hayashi N | 1996 | Cell Growth Differ1996，7，4： | 1 |
| 15 | A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene显示文摘 | Grotendorst GR Okochi H Hayashi N | 1996 | Cell Growth Differ1996，7，4： | 1 |
| 16 | Deterioration of concrete structures by acid deposition — an assessment of the role of rainwater on deterioration by laboratory and field exposure experiments using mortar specimens显示文摘 | Hiroshi Okochi Hideki Kameda Shin-ichi Hasegawa Nobuhiko Saito Ken Kubota Manabu Igawa | 2000 | Atmospheric Environment2000，，18： | 1 |
| 17 | A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene 显示文摘 | Grotendorst G R Okochi H Hayashi N | 1996 | Cell Growth Differ1996，7，4： | 1 |
| 18 | Conneetive tis- sue growth factor显示文摘 | Igarashi A Okochi H Bradhan H | 1992 | Mol Cell Biol1992，3，4： | 1 |
| 19 | Diag-nostic accuracy of cone-beam CT in the assessmentof mandibular invasion of lower gingival carcinoma:comparison with conventional panoramic radio-graphy 显示文摘 | Momin MA Okochi K Watanabe H | 2009 | Eur J Radiol2009，72，1： | 1 |
| 20 | Expression of tetraspans transmembrane family (CD9, CD37, CD53, CD63,CD81 and CD82) in normal and neoplastic human keratinocytes:an association of CD9 with alpha 3 beta 1 integrin 显示文摘 | Okochi H Kato M Nashiro K | 1997 | Br J Dermatol1997，137，6： | 1 |
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