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| 1 | 紫茎泽兰对大鼠肠道结构和肠道黏膜免疫屏障的影响显示文摘为探究紫茎泽兰对动物肠道损伤及致毒机制,本试验选取16只7周龄雄性SD大鼠经7 d适应期后随机分为对照组(饲喂不含紫茎泽兰饲料,10 g·100 g^(-1)BW)与试验组(饲喂含30%紫茎泽兰饲料,10 g·100 g^(-1)BW),试验周期为14 d,试验结束后取各肠段(取十二指肠、空肠、回肠、盲肠、结肠和直肠)组织样品,观察结构损伤,计数免疫细胞,测定sIgA(secretory immunoglobulin A,sIgA)和炎性细胞因子分泌量。结果表明:与对照组相比,紫茎泽兰可使十二指肠绒毛出血及顶端轻度坏死脱落,肠绒毛高度、隐窝深度及其比值极显著增加(P<0.01);空肠充血并伴有绒毛顶端糜烂性坏死脱落,绒毛高度及绒毛高度与隐窝深度比值极显著增加(P<0.01);回肠大量肠绒毛顶端凝固性坏死,并伴有出血与炎性浸润,绒毛高度、隐窝深度及其比值极显著增加(P<0.01);盲肠水肿及充血;结肠淋巴细胞增多、直肠大量淋巴细胞浸润及淋巴细胞增生,其中以回肠和直肠机械损伤最为严重,回肠评分增加722.36%,直肠评分增加976.00%;试验组各肠段上皮内淋巴细胞(intestinal intraepithelial lymphocytes,IELs)、固有层淋巴细胞(lamina propria lymphocytes,LPLs)和杯状细胞(goblet cells,GCs)数量极显著增加(P<0.01),同时还可极显著增加sIgA的分泌量(P<0.01),极显著增加促炎因子IL-1β、IL-2、TNF-α和IFN-γ的表达量(P<0.01),极显著降低抑炎因子IL-4、IL-10的表达(P<0.01),激活肠道炎症反应,从而破坏肠道黏膜免疫屏障,造成肠道损伤。 | 崔玉晶 高佩 文娟 OKYERE Kumi Samuel 胡延春 | 2022 | 草业学报2022，31，6： | 3 |
| 2 | How to decide? Different methods of calculating gene expression from short oligonucleotide array data will give different results显示文摘 | Millenaar F F Okyere J May S T van Zanten M Voesenek L A Petters A J | | 0，，01： | 1 |
| 3 | NASCArrays:a repository for microarray data generated by NASC's trancriptomics service显示文摘 | Craigon DJ James N Okyere J | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 4 | Acceptability of rapid di- agnostic test-based management of malaria among caregivers of under- five children in rural Ghana显示文摘 | Baiden F Owusu-Agyei S Okyere E | 2012 | PLoS One2012，7，45： | 1 |
| 5 | Self-made allostery: endogenous COMP antagonizes pathologic AT1_(A)R signaling显示文摘The identification and development of biased modulators of proximal G protein-coupled receptor(GPCR)signaling to prevent pathological disease progression has been at the forefront of recent drug discovery efforts.Recently,Fu et al.identified cartilage oligomeric matrix protein(COMP)as an endogenous negative allosteric modulator ofβ-arrestin(βarr)-dependent angiotensin Ⅱ(Ang Ⅱ)Type 1A receptor(AT1 A R)signaling,which attenuates the development of abdominal aortic aneurysm(AAA),a chronic inflammatory vascular disease lacking pharmacological treatment options. | Ama Dedo Okyere Douglas G.Tilley | 2021 | Cell Research2021，31，7： | 0 |
| 6 | Effect of Mercury on the Proximate Composition of Maize (Zea mays L,)显示文摘 | Nathaniel Owusu Boadi Harry Okyere Mercy Badu John Kenneth Mensah Idah Owusu-Appiah | 2013 | Journal of Agricultural Science and Technology(B)2013，3，7： | 0 |
| 7 | Mental health and quality of life burden in Buruli ulcer disease patients in Ghana显示文摘Background Buruli ulcer disease(BUD)is a necrotic skin neglected tropical disease(NTD)that has both a mental and physical health impact on affected individuals.Although there is increasing evidence suggesting a strong association between neglected tropical diseases(NTDs)and mental illness,there is a relative lack of information on BUD’s impact on the mental health and quality of life(QoL)of affected individuals in Ghana.This study is to assess the impact of BUD on mental health and quality of life of patients with active and past BUD infection,and their caregivers.Methods We conducted a case control study in 3 BUD endemic districts in Ghana between August and November 2019.Face-to-face structured questionnaire-based interviews were conducted on BUD patients with active and past infection,as well as caregivers of BUD patients using WHO Quality of Life scale,WHO Disability Assessment Schedule,Self-Reporting Questionnaire,Buruli Ulcer Functional Limitation Score and Hospital Anxiety and Depression Scale data tools.Descriptive statistics were used to summarize the characteristics of the study participants.Participant groups were compared using student t test and chi-square(χ2)or Fisher’s exact tests.Mean quality of life scores are reported with their respective 95%confidence intervals.Data was analysed using STATA statistical software.Results Our results show that BUD patients with active and past infection,along with their caregivers,face significant levels of distress and mental health sequelae compared to controls.Depression(P=0.003)was more common in participants with active(27%)and past BU infection(17%),compared to controls(0%).Anxiety was found in 42%(11/26)and 20%(6/29)of participants with active and past BUD infection compared to 14%(5/36)of controls.Quality of life was also significantly diminished in active BUD infection,compared to controls.In the physical health domain,mean QoL scores were 54±11.1 and 56±11.0(95%CI:49.5‒58.5 and 52.2‒59.7)respectively for participants with active infection and controls.Similarly in the psychological domain,scores were lower for active infection than controls[57.1±15.2(95%CI:50.9‒63.2)vs 64.7±11.6(95%CI:60.8‒68.6)].Participants with past infection had high QoL scores in both physical[61.3±13.5(95%CI:56.1‒66.5)]and psychological health domains[68.4±14.6(95%CI:62.7‒74.0)].Conclusions BUD is associated with significant mental health distress and reduced quality of life in affected persons and their caregivers in Ghana.There is a need for integration of psychosocial interventions in the management of the disease. | Yaw Ampem Amoako Nancy Ackam John-Paul Omuojine Michael Ntiamoah Oppong Abena Gyawu Owusu-Ansah Harriet Boateng Mohammed Kabiru Abass George Amofa Elizabeth Ofori Portia Boakye Okyere Michael Frimpong Freddie Bailey David Hurst Molyneux Richard Odame Phillips | 2021 | Infectious Diseases of Poverty2021，10，4： | 0 |
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