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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Effects on reproduction performance of administration of GnRH to early postpartum dairy cows显示文摘 | Nash Jr J G Ball L Olson J D | 1980 | J Anim Sci1980，50，： | 2 |
| 3 | Improved recoverability of microbial colonies from marine sponge samples显示文摘 | Olson J B Lord C C McCarthy P J | 2000 | Microbial Ecology2000，40，： | 1 |
| 4 | Contributions of residue 45(CD3) and heme-6-propionate to the bimolecular and geminate recombination reactions of myoglobin显示文摘 | Carver T E Olson J S | 1991 | Biochemistry1991，30，： | 1 |
| 5 | Gap filling strategies for long term energy flux data sets显示文摘 | Falge E Baldocchi D Olson R J | 2001 | Agricultural and Forest Meteorology2001，107，1： | 1 |
| 6 | Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic plaques 显示文摘 | Hagg D A Olson F J Kjelldahl J | 2009 | Atherosclerosis2009，204，2： | 1 |
| 7 | Genomics approaches to drug discovery 显示文摘 | REIDHAAR - OLSON J F RIrlEES B K HAMMER J | 2001 | J Cell Biochem Suppl2001，37，： | 1 |
| 8 | Biomechanical comparison of posterior pelvic ring fixation显示文摘 | Yinger K Scalse J Olson SA | 2003 | Orthop Trauma2003，17，7： | 1 |
| 9 | Regulation of cocaine reward by CREB显示文摘 | Carlezon WAJ Thome J Olson VG | 1998 | Science1998，282，： | 1 |
| 10 | Interference with the ex-pression of a novel human polycomb protein,hPc2,results in cellulartransformation and apoptosis 显示文摘 | Satijn DP Olson DJ van der Vlag J | 1997 | Mol Cell Biol1997，17，10： | 1 |
| 11 | Phytop]ankton population dynamics at the Bermuda Atlantic Time-Series station in the Sargasso Sea显示文摘 | DuRand M D Olson R J Chisholm S W | 2001 | Deep-Sea Res Pt II2001，48，： | 1 |
| 12 | Near-limit spread over a thin solid fuel in microgravity显示文摘 | Olson S L Ferkul P V T'ien J S | | 0，，： | 1 |
| 13 | Positron annihi- lation lifetime spectroscopy of poly ( ethylene terephthalate) : Contributions from rigid and mobile amorphous fractions 显示文摘 | OLSON B LIN J NAZARENKO S | 2003 | Macromolecules2003，36，20： | 1 |
| 14 | Hypertension and cognitive function:pathophysiologic effects of hypertension on the brain显示文摘 | Manolio TA Olson J Longstreth WT | 2003 | Curr Hypertens Rep2003，5，3： | 1 |
| 15 | Opportunities for im- proving milk production efficiency in dairy cattle: triennial lactation symposium 显示文摘 | Connor E E Hutchison J L Olson K M | 2011 | J Anim Sci2011，90，： | 1 |
| 16 | The first use of a combined value auction for transportation services显示文摘 | Ledyard J O Olson M Porter D | 2002 | Interfaces2002，32，5： | 1 |
| 17 | Cardiac plasticity显示文摘 | Hill J A Olson E N | 2008 | New England J Med2008，358，13： | 1 |
| 18 | Stratification of sudden death risk in patients receiving long-term amiodarone treatment for sustained ventricular tachycardia or ventricular fibrillation显示文摘 | WOELFEL A SIMPSON R J | 1993 | Am J Cardiol1993，71，10： | 1 |
| 19 | Analysis of fluid-structure interactions,a direct symmetric coupled formulation based on the fluid velocity potential显示文摘 | Olson L G Bathe K J | 1985 | Computers and Structures1985，，21： | 1 |
| 20 | In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex显示文摘 | McAndrew R S Olson B J Kadirjan-Kalbaeh D K | 2008 | Biochemical Journal2008，412，2： | 1 |
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