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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Landscape features and weather influence nest survival of a ground-nesting bird of conservation concern,the greater sage-grouse,in humanaltered environments显示文摘Introduction:Ground-nesting birds experience high levels of nest predation.However,birds can make selection decisions related to nest site location and characteristics that may result in physical,visual,and olfactory impediments to predators.Methods:We studied daily survival rate[DSR]of greater sage-grouse(Centrocercus urophasianus)from 2008 to 2010 in an area in Wyoming experiencing large-scale alterations to the landscape.We used generalized linear mixed models to model fixed and random effects,and a correlation within nesting attempts,individual birds,and years.Results:Predation of the nest was the most common source of nest failure(84.7%)followed by direct predation of the female(13.6%).Generally,landscape variables at the nest site(≤30 m)were more influential on DSR of nests than features at larger spatial scales.Percentage of shrub canopy cover at the nest site(15-m scale)and distances to natural gas wells and mesic areas had a positive relationship with DSR of nests,whereas distance to roads had a negative relationship with DSR of nests.When added to the vegetation model,maximum wind speed on the day of nest failure and a 1-day lag in precipitation(i.e.,precipitation the day before failure)improved model fit whereby both variables negatively influenced DSR of nests.Conclusions:Nest site characteristics that reduce visibility(i.e.,shrub canopy cover)have the potential to reduce depredation,whereas anthropogenic(i.e.,distance to wells)and mesic landscape features appear to facilitate depredation.Last,predators may be more efficient at locating nests under certain weather conditions(i.e.,high winds and moisture). | Stephen L Webb Chad V Olson Matthew R Dzialak Seth M Harju Jeffrey B Winstead Dusty Lockman | 2012 | Ecological Processes2012，1，1： | 2 |
| 5 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hnq95kbbn0npx60f9.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 6 | Bubble formation in supersaturated hydrocarbon mixtures 显示文摘 | Kennedy H T Olson C R | 1952 | Petroleum Transaction AIME1952，195，： | 1 |
| 7 | Gap filling strategies for long term energy flux data sets显示文摘 | Falge E Baldocchi D Olson R J | 2001 | Agricultural and Forest Meteorology2001，107，1： | 1 |
| 8 | Wound complications associated with incision enlargement for foldable intraocular lens implantation during cataract surgery显示文摘 | Kumar R Reeves DL Olson RJ | 2001 | J Cataract Refract Surg2001，27，11： | 1 |
| 9 | The many roles of histone deacetylases in development and physiology: implications for disease and therapy 显示文摘 | Haberland M Montgomery R L Olson E N | | Nat Rev Genet0，10，1： | 1 |
| 10 | Phytop]ankton population dynamics at the Bermuda Atlantic Time-Series station in the Sargasso Sea显示文摘 | DuRand M D Olson R J Chisholm S W | 2001 | Deep-Sea Res Pt II2001，48，： | 1 |
| 11 | Beans, as a source of dietary fiber, increase cholecystokinin and apolipoprotein B48 response to test meals in men显示文摘 | BOURDON I OLSON B BACKUS R | 2001 | The Journal of nutrition2001，131，5： | 1 |
| 12 | Acute-on chronic liver failure显示文摘 | Jalan R Gines P Olson JC | 2012 | J Hepatol2012，57，6： | 1 |
| 13 | Gap filling strategies for defensible annual sums of net ecosystem exchange显示文摘 | Falge E Baldocchi D Olson R | 2001 | Agricultural and Forest Meteorology2001，107，： | 1 |
| 14 | Stratification of sudden death risk in patients receiving long-term amiodarone treatment for sustained ventricular tachycardia or ventricular fibrillation显示文摘 | WOELFEL A SIMPSON R J | 1993 | Am J Cardiol1993，71，10： | 1 |
| 15 | Finite faults and inversion theory with applications to the 1979 Imperial valley earthquake 显示文摘 | Olson A H Apsel R | 1982 | Bulletin of the Seismological Society of America1982，72，： | 1 |
| 16 | Signaling pathways in skeletal muscle remodeling显示文摘 | BASSEL - DUBY R OLSON E N | 2006 | Annu Rev of Biochem2006，75，： | 1 |
| 17 | In vivo quantitative relationship between plastid division proteins FtsZ1 and FtsZ2 and identification of ARC6 and ARC3 in a native FtsZ complex显示文摘 | McAndrew R S Olson B J Kadirjan-Kalbaeh D K | 2008 | Biochemical Journal2008，412，2： | 1 |
| 18 | Electrochemical oxygen transfer during direct current arc welding 显示文摘 | Kim J H Frost R H Olson D L | 1998 | Welding Journal1998，77，12： | 1 |
| 19 | Spatial and temporal distributtons of prochlorophyte picoplankton in the North Atlantic Ocean显示文摘 | Olson R L Chisholm S W Zettler E R | 1990 | Deep Sea Research1990，37，： | 1 |
| 20 | Influence of solidificationkinetics on aluminium weld grain refinement 显示文摘 | Dvomak M J Frost R H Olson I) L | 1991 | Welding Jour-nal1991，70，10： | 1 |
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