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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | High-sensitivity troponin I and amino-terminal pro-B-type natriuretic peptide predict heart failure and mortality in the generalpopulation 显示文摘 | Paul M Omar F Christopher G | 2014 | ClinChem2014，60，9： | 1 |
| 3 | Identification and characterization of a novel anti-viral peptide against avian influenza virus H9N2显示文摘 | Rajik M Jahanshiri F Omar AR | | 0，，： | 1 |
| 4 | Nanoclay reinforced HDPE as a matrix for wood-plastic composites显示文摘 | Omar F Laurent M M | 2008 | Composites Science and Technology2008，68，： | 1 |
| 5 | The influence of bone type on the gene expression in normal bone and at the bone-implant interface: experiments in animal model显示文摘 | Omar O Suska F Lenneras M | 2011 | Clin Implant Dent Relat Res2011，13，2： | 1 |
| 6 | Molecular diversity of lactic acid bacteria from cassava sour starch (Colombia)显示文摘 | OMAR B AMPE F N RAINBAULT M | 2000 | System Appl Microbiol2000，23，： | 1 |
| 7 | Relationship between endogenous free polyamine content and ethylene evolution during fruit growth and ripening of Japanese pear (Pyrus pyrifolia Nakai )显示文摘 | OMAR F M TANABE K ITAI A TAMURA F LTAMURA H | 2005 | J Japan Soc Hort Sci2005，74，3： | 1 |
| 8 | Design, synthesis and antiinflammatory activity of some 1,3,4 oxadiazole de rivatives显示文摘 | Omar F A Mahfouz N M Rahman M A | 1996 | Eur J Med Chem1996，31，6： | 1 |
| 9 | RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status显示文摘 | Omar M F Ito K Nga M E | 2012 | Pathol Oncol Res2012，18，4： | 1 |
| 10 | Utilization of Interventional Radiology in the Postoperative Management of Patients after Surgery for Locally Advanced and Recurrent Rectal Cancer显示文摘 | Llaguna Omar H Calvo Benjamin F Stitzenberg Karyn B Deal Allison M Burke Charles T Dixon Robert G Stavas Joseph M Meyers Michael O | 2011 | The American Surgeon2011，，8： | 1 |
| 11 | Utility of certain π-acceptors for the spectrophoto- metric determination of some penicillins 显示文摘 | Askal Hassan F Saleh Gamal A Omar Nabil M | 1991 | Analyst1991，116，4： | 1 |
| 12 | Serum copper levels in obesity:a study of 32 cases显示文摘 | Omar S Abdennebi M Ben Mami F | 2001 | Tunis Med2001，79，67： | 1 |
| 13 | Application of supereritical CO2 in lipid extraction - A review 显示文摘 | Sahena F Zaidul I S M Jinap S Kafim A A Abbas K A Norulaini N A N Omar A K M | 2009 | Journal of Food Engineering2009，95，2： | 1 |
| 14 | Sistemas transcurrentes de escala litosferica en el Sur del Peru显示文摘 | Thierry S Javier J Victor C William M Conrado B Michel F Pierrick R Harmuth A Jorge A Luis C Alexander F Ivanoff I Omar L Mirian M Paola M Francis O Yovani O Adan P and Rildo R | | 0，，05： | 1 |
| 15 | Dynamic Wavelet-based Tool for Gearbox Diagnosis显示文摘 | Omar F K Gaouda A M | 2012 | Mechanical Systems and Signal Processing2012，26，： | 1 |
| 16 | Sequense omalysis of Malaysian infectious bursal disease virus isolate and the use of reverse franscriptase nested polymerase chain reaction enymelinked irmnunosorbent assay for the detection of VP2 by pervariable region显示文摘 | Phong S F M Hair-Bejo Omar A IL | 2003 | Avian Dis2003，47，1： | 1 |
| 17 | Logo recognition system using angular radial transform descriptors显示文摘 | Wahdan O M Omar K Nasrudin M F | 2011 | Journal of Computer Science2011，7，9： | 1 |
| 18 | Storage of hydrogen, methane, and carbon dioxide in highly porous covalent organic frameworks for clean energy applications 显示文摘 | Hiroyasu F Omar M Y | 2009 | Journals of American Chemical Society2009，131，： | 1 |
| 19 | Nanoclay reiforced HDPE as a matrix for wood-plastic composites 显示文摘 | OMAR F LAURENT M M | 2008 | Compos Sci Technol2008，68，： | 1 |
| 20 | Assessing implications of land - use and land - cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | Alejandro F S Miguel M R Omar R M | 2007 | Biological Conservation2007，138，12： | 1 |
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