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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Estrogen receptor-[alpha] signaling in osteoblast progenitors stimulates cortical bone accrual显示文摘 | Almeida Maria Iyer Srividhya Martin-Millan Marta Bartell Shoshana M Han Li Ambrogini Elena Onal Melda Xiong Jinhu Weinstein Robert S Jilka Robert L O’Brien Charles A Manolagas Stavros C | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 3 | Intravitreal bevacizumab for treatment of uveitic macular edema显示文摘 | Cordero Coma M Sobrin L Onal S Christen W Foster CS | 2007 | Ophthalmology2007，114，： | 1 |
| 4 | Matrix-embedded cells control osteoclast formation显示文摘 | Xiong J Onal M Jilka R L | 2011 | Nature Medicine2011，17，10： | 1 |
| 5 | Flotation of Aladag- oxide lead-zinc ores显示文摘 | ONAL G BULUT G G L A KANGAL 0 PEREK K T ARSLAN F | 2005 | Minerals Engineering2005，18，2： | 1 |
| 6 | Intravitreal bevacizumab for treatment of uveitic macular edema显示文摘 | Cordero Coma M Sobrin L Onal S Ohristen W Foster CS | 2007 | Ophthalmology2007，114，： | 1 |
| 7 | Effect of enzymatic pretreatment on the mechanical properties of jute fiber-reinforced polyester com- posites 显示文摘 | Karaduman Y Gokcan D Onal L | 2013 | Journal of Composite Materials2013，47，10： | 1 |
| 8 | Intravitreal bevacizumab for treatment of uveitic macular edema 显示文摘 | CORDERO COMA M SOBRIN L ONAL S | 2007 | Ophthalmology2007，114，8： | 1 |
| 9 | Long term outcome and prognostic factors in patients with cervical carcinoma~ a retro- spective study显示文摘 | Atahan I L Onal C Ozyar E | 2007 | Int J Gynecol Cancer2007，17，4： | 1 |
| 10 | Contribution of fabric characteristics and laundering to shrinkage of weft knitted fabric显示文摘 | Onal L Candan C | 2003 | Textile Research Journal2003，，3： | 1 |
| 11 | Intravitreal bevacizumab for treatment of uveitic macular edema 显示文摘 | Cordero CM Sobrin L Onal S | 2007 | Ophthalmology2007，114，8： | 1 |
| 12 | Predicting the seam strength of notched webbings for parachute assemblies using the taguchi's design of experiment and artificial neural net- works 显示文摘 | Onal L Zeydan M Korkmaz M | 2009 | Textile Research Journal2009，79，5： | 1 |
| 13 | Endobronchial schwannoma with massive hemoptysis显示文摘 | Onal M Ernam D Atikcan S Memis L | 2009 | Tuberk Toraks2009，57，1： | 1 |
| 14 | Intravitreal bevacizumab for treatment of uveitic macular edema显示文摘 | Cordero Coma M Sobrin L Onal S | 2007 | Ophthalmology2007，114，： | 1 |
| 15 | Comparative study on the characteristics of knitted fabrics made of vortex-spun viscose yarns 显示文摘 | ORTLEK H G ONAL L | 2008 | Fibers and Polymers2008，9，2： | 1 |
| 16 | Mechanical properties of surface modified jute fiber/polypropylene nonwoven composites显示文摘 | Sayeed M M A Rawal A Onal L | 2014 | Polym Compos2014，35，6： | 1 |
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