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| 1 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 2 | Recent management of urinary stone disease in a pediatric population显示文摘The incidence of stone disease has been increasing and the risk of recurrent stone formation is high in a pediatric population. It is crucial to use the most effective method with the primary goal of complete stone removal to prevent recurrence from residual fragments. While extracorporeal shock wave lithotripsy(ESWL) is still considered first line therapy in many clinics for urinary tract stones in children, endoscopic techniques are widely preferred due to miniaturization of instruments and evolution of surgical techniques. The standard procedures to treat urinary stone disease in children are the same as those used in an adult population. These include ESWL, ureterorenoscopy, percutaneous nephrolithotomy(standard PCNL or mini-perc), laparoscopic and open surgery. ESWL is currently the procedure of choice for treating most upper urinary tract calculi in a pediatric population. In recent years, endourological management of pediatric urinary stone disease is preferred in many centers with increasing experience in endourological techniques and decreasing sizes of surgical equipment. The management of pediatric stone disease has evolved with improvements in the technique and a decrease in the size of surgical instru-ments. Recently, endoscopic methods have been safely and effectively used in children with minor complications. In this review, we aim to summarize the recent management of urolithiasis in children. | Ozgu Aydogdu Ayhan Karakose Orcun Celik Yusuf Ziya Atesci | 2014 | World Journal of Clinical Pediatrics2014，3，1： | 5 |
| 3 | Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats显示文摘我们在一个试验性的老鼠模型把 intratesticular 臭氧治疗的功效与 intraperitoneal 臭氧治疗作比较。为这个目的, 24 只老鼠加 intratesticular 臭氧(O 信息技术) 包括假冒操作, torsion/detorsion,加 intraperitoneal 臭氧(O-IP ) 的 torsion/detorsion,和 torsion/detorsion 被划分成四个组。O-IP 臭氧组收到了臭氧的 4 mg kg −1 intraperitoneal 注射,并且 O 信息技术组 epididymally 收到了一样的注射。在在 detorsion 以后的 4 h,老鼠被牺牲, orchiectomy 材料组织病理学说地被估计。在到 Sertoli 房间的生精的小管和损坏的精子发生组织病理学说地用 Johnsen 得分系统在睾丸被评估。我 -- 在睾丸织物的 NOS 和电子 NOS 活动也被评估。Torsion-detorsion 引起了一个减少的 Johnsen 分数并且增加了 spermatogonial 和 Sertoli 房间的 apoptosis。阻止的臭氧注射在 Johnsen 分数和 i 增加 -- NOS 水平。O-IP 组的电子 NOS 水平比 O-IP 组,和 i 的显著地低 --O 信息技术组的 NOS 水平比 O-IP 组的显著地低。本地臭氧治疗是比在改进 IRI 相关的阴囊的扭转的全身的臭氧治疗更有效的。我们的学习是第一证明臭氧治疗的 intratesticular 实现的功效比 intraperitoneal 臭氧治疗的高。 | Fatih Mete Huseyin Tarhan Orcun Celik Ilker Akarken Kamil Vural Rahmi Gokhan Ekin Isil Aydemir Yusuf Ozlem Ilbey | 2017 | Asian Journal of Andrology2017，19，1： | 5 |
| 4 | Triorchidism: a rare genital abnormality显示文摘 | Orcun Celik Salih Budak Ozgur Cakmak Huseyin Tarhan Okan Nabi Yalbuzdag Aziz Peker Yusuf Ozlem Ilbey | 2014 | Asian Journal of Andrology2014，16，6： | 4 |
| 5 | Visual acuity and endothelial cell density with respect to the graft thickness in Descemet's stripping automated endothelial keratoplasty: one year results显示文摘AIM: To evaluate the visual acuity and endothelial cell density according to the thickness in Descemet's stripping automated endothelial keratoplasty(DSAEK)one year after surgery.METHODS: DSAEK patients' data were reviewed. Thirty seven eyes of 37 patients who underwent DSAEK for pseudophakic bullous keratopathy(PBK) were included in this study. Graft thickness was measured with optical coherence tomography(OCT) 12 mo after DSAEK. Eyes were divided into 3 groups based on the graft thickness:thick(>200 μm), medium-thick(150-200 μm) and thin(<150 μm). Best corrected visual acuity(BCVA),endothelial cells density(ECD) and complications were assessed and comparisons were done between groups.RESULTS: Median thickness of postoperative grafts was 188(range 73-317 μm). There was no significant difference in age, sex, preoperative BCVA, or follow-up period between DSAEK groups. At postoperative 12 mo,mean BCVA was 0.28±0.10 in thick graft group, 0.52±0.08 in medium-thick graft group, and 0.72 ±0.06 in thin graft group. Thin grafts showed better postoperative BCVA as compared with the medium-thick and thick grafts(P =0.001). Thick graft group had 1637.44 ±88.19-mm2,medium thick graft had 1764.50±34.28-mm2 and thin graft group had 1845.30 ±65.62-mm2. Thin graft group had better ECD at 12 mo after surgery(P =0.001).CONCLUSION: Thin grafts after DSAEK ensure better visual rehabilitation. Eyes with thin grafts had significantly lesser loss of ECD compared to eyes withmedium-thick and thick grafts one year after surgery. | Banu Torun Acar Mehmet Orcun Akdemir Suphi Acar | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 3 |
| 6 | Comparison of contrast sensitivity and visual acuity between deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus显示文摘AIM: To evaluate postoperative visual acuity and contrast sensitivity results following deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in patients with keratoconus (KC). METHODS: All the patients' records with KC who had PK or DALK surgery between May 2010 and May 2011 were retrospectively reviewed. Sixty patients who underwent successful corneal transplantation for KC: 30 eyes underwent DALK and 30 eyes underwent PK were included in this study. Preoperative and postoperative mean logarithm of the minimum angle of resolution (logMAR) uncorrected visual acuity (UCVA), logMAR best spectacle-corrected visual acuity (BSCVA) and intraocular pressure (IOP) were evaluated. Contrast sensitivity tests (CS) were done preoperative and 2 months after all sutures had removed. All surgeries were performed under regional anesthesia (retrobulbar anesthesia) by 1 surgeon (B.K.) who was experienced in penetrating and lamellar keratoplasty techniques. RESULTS: The mean age of the DALK group was 29.67±4.95 (range 18-40) years and the PK group was 28.7±3.53 (range 18-39) years. Preoperatively there was no significant difference in the logMAR UCVA, logMAR BSCVA and IOP between the DALK (1.281±0.56; 0.97±0.85; 12.07±2.12mmHg) and PK (1.34±0.21; 0.98±0.21; 13±2.12mmHg) groups. One-year after surgery there was no significant difference in the mean logMAR UCVA and IOP between the DALK (0.46±0.37; 11.73±2.1mmHg) and PK (0.38±0.21; 12±2.12mmHg) groups. The mean contrast sensitivity was evaluated by CC-100 Topcon LCD at 1.5, 2.52, 4.23, 7.10 and 11.91 cycles per degree (cs/deg) spatial frequencies before and 2 months after the all sutures had removed. CONCLUSION: All patients with keratoconus in both DALK and PK groups performed good visual function postoperatively. The mean contrast sensitivity increased considerably at all spatial frequencies compared with preoperative levels in the DALK and PK groups. The mean post-operative evaluation of contrast sensitivity measurements was not significantly different between the two groups. | Mehmet Orcun Akdemir Baran Kandemir Isil Bahar Sayman Cem Selvi OmerKamil Dogan | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
| 7 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?显示文摘AIM: To study the levels of adiponectin in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) in comparison with control group.METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age,gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method.RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14±3.4 μg/mL vs12.4±9.4 μg/mL,respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r: -0.33, P<0.01),HOMA (r: -0.26, P<0.05), proinsulin (r: -0.32, P<0.01),AST (r: -0.25, P<0.05), ALT (r: -0.26, P<0.05) or GGT (r: -0.22, P<0.05). In multiple regression analysis models,adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI.CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics. | Haluk Sargin Mehmet Sargin Hülya Gozu Asuman Orcun Gülcan Baloglu Murat Ozisik Mesut Seker Oya Uygur-Bayramicli | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 8 | Prognostic significance of primary tumor localization in stage Ⅱ and Ⅲ colon cancer显示文摘IM To investigate the effects of tumor localization on disease free survival(DFS) and overall survival(OS) in patients with stage Ⅱ-Ⅲ colon cancer.METHODS This retrospective study included 942 patients with stage Ⅱ and Ⅲ colon cancer, which were followed up in our clinics between 1995 and 2017. The tumors from the caecum to splenic flexure were defined as right colon cancer(RCC) and those from splenic flexure to the sigmoid colon as left colon cancer(LCC).RESULTS The median age of the patients was 58 years(range: 19-94 years). Male patients constituted 54.2%. The rates of RCC and LCC were 48.4%(n = 456) and 51.6%(n = 486), respectively. During the median follow-up of 90 mo(range: 6-252 mo), 14.6% of patients developed recurrence and 9.1% of patients died. In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, DFS was similar in terms of primary tumor localization(stage Ⅱ; P = 0.547 and P = 0.481, respectively; stage Ⅲ; P = 0.976 and P = 0.978, respectively). In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization(stage Ⅱ; P = 0.381 and P = 0.947, respectively; stage Ⅲ; P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC(26 ± 6.2 mo) and LCC(34 ± 4.9 mo) cases was eight months(P = 0.092).CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage Ⅱ or Ⅲ colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients. | Abdullah Sakin Serdar Arici Saban Secmeler Orcun Can Caglayan Geredeli Nurgul Yasar Cumhur Demir Osman Gokhan Demir Sener Cihan | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 1 |
| 9 | Serum concentrations of CA125, CA15-3, CA19-9 and CEA in normal pregnancy : a longitudinal study显示文摘 | Ercan S Kaymaz O Yiicel N Orcun A | 2012 | Arch Gynecol Obstet2012，285，： | 1 |
| 10 | Effects of ejaculation on serum prostate-specific antigen levels 显示文摘 | Demir K Tarhan F Orcun A | 2014 | Turk Uroloji Dergisi2014，40，： | 1 |
| 11 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nonalcoholic male patients显示文摘 | Sargin H Sargin M Gozu H Orcun A Baloglu G Ozisik M Seker M Uygur-Bayramicli O | | 0，，： | 1 |
| 12 | Complications of urologic laparoscopic surgery: A center surgeon’s experience involving 601 procedures including the learning curve显示文摘 | Yigit Akin Mutlu Ates Orcun Celik Murat Ucar Selcuk Yucel Tibet Erdogru | 2012 | Kaohsiung Journal of Medical Sciences2012，，： | 1 |
| 13 | A rare case: paratesticular leiomyosarcoma显示文摘 | Orcun Celik Gonca Unlu | 2013 | Asian Journal of Andrology2013，15，6： | 1 |
| 14 | Study on reduction of air consumption on air-jet weaving machines显示文摘 | KTEPE A-zer BOZKAN Orcun | 2008 | Textile Research Journal2008，78，9： | 1 |
| 15 | Study on reduction ofair consumption on weaving machines 显示文摘 | GOKTEPE Ozer BOZKAN Orcun | 2008 | TextileResearch Journal2008，78，9： | 1 |
| 16 | Study on reduction of air-consumption on air-jet weaving machines显示文摘 | GOKTEPE Ozer BOZKAN Orcun | 2008 | Textile Research Journal2008，78，9： | 1 |
| 17 | scheduling of batch processes with operational uncertainties显示文摘 | Orcun S Ahinel IK Hortascu O | 1996 | Compution Chem Eng1996，20，： | 1 |
| 18 | In-vivo corneal biomechanical analysis of unilateral keratoconus显示文摘AIM: To evaluate and compare corneal biomechanical findings measured by ocular response analyzer,topographic and pachymetric findings in patients with unilateral keratoconus patients and healthy controls.· METHODS: This is an observational, case-control study. Patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye were compared with sex and age matched with controls healthy subjects. All subjects were evaluated with rotating scheimpflug imaging system. The receiver-operating-characteristic curves were analyzed to evaluate the sensitivity and specificity of the parameters.·RESULTS: Twenty-seven patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye were compared with 40 eyes of 40 normal subjects. Corneal hysteresis(CH) was 8.0 ±1.7 mm Hg in keratoconus group, 8.3 ±1.6 mm Hg in forme fruste keratoconus group, and 9.8 ±1.6 mm Hg in control groups(P =0.54 between keratoconus and forme fruste keratoconus groups, P <0.01 between control group and other groups).Corneal resistance factor(CRF) was 7.1 ±2.2 mm Hg in keratoconus group, 7.8 ±1.2 mm Hg in forme fruste keratoconus group and 9.9 ±1.5 mm Hg in control group(P <0.001 between control group and other groups).Using receiver-operating-characteristic analysis, the area under curve values of the parameters to distinguish forme fruste keratoconus from control subjects were: CH(0.768), CRF(0.866). Best cut-off points were 9.3 mm Hg and 8.8 mm Hg for CH and CRF respectively.·CONCLUSION: Ocular response analyzer parameters(CH and CRF) are found to be significantly lower in forme fruste keratoconus patients compared to normal control subjects. | Orhan Ayar Mehmet Cuneyt Ozmen Orkun Muftuoglu Mehmet Orcun Akdemir Mustafa Koc Kemal Ozulken | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 0 |
| 19 | Extragonadal germ cell tumor with the "burned-out" phenomenon presented a multiple retroperitoneal masses: a case report显示文摘 | Salih Budak Orcun Celik Hakan Turk Tufan Suelozgen Yusuf Ozlem Ilbey | 2015 | Asian Journal of Andrology2015，17，1： | 0 |
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