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| 1 | Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer显示文摘AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study. | Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata | 2010 | World Journal of Gastroenterology2010，16，10： | 14 |
| 2 | Performances of glaucoma operations with Kahook Dual Blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients显示文摘AIM:To compare surgical outcomes of phacoemulsification combined with glaucoma surgical techniques performed with either Kahook Dual Blade(KDB)or iStent for Japanese patients with either primary open angle glaucoma or exfoliation glaucoma.METHODS:We retrospectively evaluated the surgical outcomes of 129 eyes of 84 Japanese patients with glaucoma who underwent KDB or 44 eyes of 34 patients who underwent phacoemulsification with iStent procedures combined with cataract surgery.The primary outcome was surgical success or failure[with surgical failure being indicated by<20%reduction from preoperative intraocular pressure(IOP)or IOP>18 mm Hg as criterion A;IOP>14 mm Hg as criterion B on two consecutive study visits;or reoperation requirement].In addition,we assessed the number of postoperative glaucoma medications and the resulting complications.RESULTS:The probability of success was significantly higher in the KDB group than in the iStent group for criterion A(60.2%vs 46.4%,P=0.019).In the KDB group,the mean preoperative IOP of 19.8±7.3 mm Hg decreased significantly to 13.0±3.1 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.5±1.4 decreased significantly to 1.6±1.6(P<0.01)12 mo postoperatively.In the iStent group,the mean preoperative IOP of 17.8±2.9 mm Hg significantly decreased to 14.3±2.3 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.2±1.1 decreased significantly to 0.9±1.4(P<0.01)12 mo postoperatively.The overall IOP reduction percentage was higher in the KDB group(26.2%)than in the iStent group(19.0%)12 mo postoperatively(P=0.03).Hyphema occurred significantly more frequently in the KDB group(16.3%)than in the iStent group(2.3%,P=0.017).CONCLUSION:KDB and iStent procedures combined with cataract surgery both result in significant IOP and glaucoma medication reductions after the 12-month followup.The patients in the KDB group have a higher success rate for the target IOP of less than 18 mm Hg and a higher complication rate than those in the iStent group. | Kentaro Iwasaki Yoshihiro Takamura Yusuke Orii Shogo Arimura Masaru Inatani | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 3 | Differential immunophenotypic analy- sis of dendritic cell tumours显示文摘 | Orii T Takeda H Kawata S | 2010 | J Clin Pathol2010，63，6： | 1 |
| 4 | Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma显示文摘 | Zhai YL Nikaido T Orii A | 1999 | Genecol Oncol1999，75，： | 1 |
| 5 | Assessmentof liver graft function after cold preservation using ^31P and ^23Na magnetic resonance spectroscopy显示文摘 | Orii T OhkohchiN Satomi S | 1992 | Transplantation1992，53，： | 1 |
| 6 | Nippon suisan gakkaishi显示文摘 | SHIOMI K ORII M YAMANAKA H | | 19s70，53，： | 1 |
| 7 | Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD 显示文摘 | Orii F Ashida T Nomura M | 2002 | Biochem Biophys Res Commun2002，296，5： | 1 |
| 8 | Two-dimensional speckle tracking echocardiography for the prediction of reversible myocardial dysfunc- tion after acute myocardial infarction:comparison with magnetic reso- nance imaging 显示文摘 | Orii M Hirata K Tanimoto T | 2015 | Echocardiography2015，32，5： | 1 |
| 9 | Simultaneous high-performance liquidchromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamicacid, cinnamaldehyde and glycyrrhizin in Kampo medicines显示文摘 | Okamura N Miki H Orii H | 1999 | J Pharm Biomed Anal1999，19，34： | 1 |
| 10 | Tranilast inhibits the proliferation of uterine leiomyoma cells in vitro through G1 arrest associated with the induction of p21 ( wafl ) and p53 显示文摘 | Shime H Kariya M Orii A | 2002 | J Clin Endocrinol Metab2002，87，12： | 1 |
| 11 | 显示文摘 | Shime H Kariya M Orii A | 2002 | J Clin Endocrinol Metab2002，87，12： | 1 |
| 12 | Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis显示文摘 | Honda M Orii F Ayabe T | | 0，，： | 1 |
| 13 | Three‐dimensional Underwater Shape Measurement of Tuna Longline Using Ultrasonic Positioning System and ORBCOMM Buoy显示文摘 | MIYAMOTO Y UCHIDA K ORII R | 2006 | Fisheries Science2006，72，1： | 1 |
| 14 | Distribution of the stem cells (neoblasts) in the planarian Dugesia japonica 显示文摘 | Orii H Sakurai T Watanabe K | 2005 | Dev Genes Evol2005，215，3： | 1 |
| 15 | Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis 显示文摘 | Honda M Orii F Ayabe - T | 2000 | Gastroentcrology2000，118，5： | 1 |
| 16 | Sited-directed mutagenesis of bacterial hemoglobin:The role of glutamine (ET) in oxygenbinding in the distal heme pocket显示文摘 | Dikshit K L Orii Y Navani N | 1998 | Archives of Biochemistry and Biophysics1998，349，1： | 1 |
| 17 | Analysis of Nitrification in Agricultural Soil an dImprovement of Nitrogen Circulation with Autotrophic A mmonia - Oxidizing Bacteria 显示文摘 | Matsuno T H orii S Sato T | 2013 | Applied Biochemistry and Biotechnalogy2013，169，3： | 1 |
| 18 | Identification and origin of the germline stem cells as revealed by the expression of nanos-related gene in planarians显示文摘 | Sato K Shibata N Orii H | | 0，，09： | 1 |
| 19 | Expression of vasa (vas)-related genes in germline cells and totipotent somatic stem cells of planarians显示文摘 | Shibata N Umesono Y Orii H | | 0，，01： | 1 |
| 20 | Defming the pathway for Tatmediated delivery of beta-glucuronidase in cultured cells and MPS VII mice显示文摘 | Orii KO Grubb JH Vogler C | 2005 | Mol Ther2005，12，： | 1 |
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