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| 1 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 2 | Adjuvant radiochemotherapy for gastric cancer:should weuse prognostic factors to select patients?显示文摘Radiotherapy has a not well-established role in the pre-operative and in the post-operative setting in gastric cancer(GC) patients. Randomized trials report controversial outcomes and impact on survival. In the D2 loco-regional node resection era, after a wellperformed radical surgery, local treatment using radiotherapy combined to chemotherapy should be considered for locally advanced GC. Prognostic factors could help the better selection of subgroups that present high risk of loco-regional recurrence. Then, the addition of radiotherapy could improve the diseasefree survival and also quality of life. There are no large prospective studies that have assessed specific factors predicting for recurrence or survival, but only retrospective series, some of them including high number of patients with homogeneous characteristics. In locally advanced GC adding radiotherapy to the postoperative chemotherapy seems to improve outcomes and quality of life. Prognostic factors such as T-stage, N-status, nodal ratio, and other histological factors should be considered to submit patients to postoperative combined treatment. Larger prospective series are necessary to investigate the role of combined chemoradiation after radical D2-resection, especially in locally advanced GC. Further prospective investigations are needed to suggest prognostic factors that have significant impact on survival and recurrence, improving the management and outcomes, particularly in locally advanced GC patients. | Linda Agolli Riccardo Maurizi Enrici Mattia Falchetto Osti | 2016 | World Journal of Gastroenterology2016，22，3： | 3 |
| 3 | Impact of number of run-off vessels on interwoven nitinol mesh stents patency in the femoropopliteal segment显示文摘Objective To evaluate the impact of run-off vessels number on the outcomes of Supera stent(Abbott Vascular,Santa Clara,Calif,USA)for treatment of femoropopliteal occlusive disease.Methods We retrospectively evaluated the medical records of 188 consecutive patients(mean age 68.2±9.6 years,100 males)undergone angiography and woven mesh stent implantation in femoral or popliteal arteries or both arterial segments,in our institution between January 12014 and January 12018.Target lesion revascularization and major adverse limb events at 12-month were evaluated comparing patients with 1-,2-or 3-run-off vessels in the foot.Results Interventional success was achieved in 100%.Stent implantation involved in the femoral site in 56 patients(30.3%),the femoropopliteal in 92 patients(48.9%)and the popliteal site in 40 patients(21.3%).A significant improvement of ankle-brachial index(0.29±0.6 vs.0.88±0.3,P<0.001)and Rutherford class(5.3±0.8 vs.0.7±1.9,P<0.01)were observed before discharge.The median follow-up duration was 12.3 months(inter quartile range:11.0 to 13.9).During the follow-up period,52 patients(27.6%)had clinical events.Primary patency at 12 months was 72.4%.The primary patency significantly increased when the runoff status.Comparing the number of events among patients with different number of run-off vessels,a significant difference(P<0.001)was observed for patients having one(24.0%)and two run-off vessels(15.0%).Conclusions The outcomes of Supera stent in femoropopliteal occlusive disease depend strictly on the number of run-off vessels. | Gianluca Rigatelli Marco Zuin Fabio Dell’Avvocata Dobrin Vassilev Stefano Barison Sabrina Osti Alberto Mazza Alberto Sacco | 2020 | Journal of Geriatric Cardiology2020，17，9： | 2 |
| 4 | Dextran cross-linked gelatin microspheres as a drug delivery system显示文摘 | Cortesi R Esposito E Osti M | 1999 | European Journal of Pharmaceutical Sciences1999，47，2： | 1 |
| 5 | Ultrasound of thyroid, parathyroid glands and neck lymph nodes显示文摘 | Solbiati L Osti V Cova L | 2001 | Eur Rad2001，11，12： | 1 |
| 6 | Neoadjuvant chemoradiation for locally advanced carcinoma of the rectum 显示文摘 | Osti MF Valeriani M Masoni L | 2004 | Tumori2004，90，3： | 1 |
| 7 | Annular tears and disc degeneration in the lumbar spine,a post-modem study of 135 discs显示文摘 | Osti OL Vernon-Robeas B Moore R | | 0，，： | 1 |
| 8 | Radiofrequency thermal ablationof hepatic metastases显示文摘 | Luigi Solbiati Tiziana Ierace Massimo Tonolini Valeria Osti Luca Cova | 2001 | European Journal of Ultrasound2001，，2： | 1 |
| 9 | MRI and discography of annular tears and intervertebral disc degeneration:a prospective clinical comparison显示文摘 | Osti OL Fraser RD | 1992 | J Bone Joint Surg(Br)1992，74，3： | 1 |
| 10 | Annular tears and disc degeneration in the lumbar spine: a post-mortem study of 135 discs显示文摘 | Osti OL Vernon-Roberts B Moore R | 1992 | J Bone Joint Surg Br1992，74，5： | 1 |
| 11 | Changes in end plate vascul arity following an outer annulus tear显示文摘 | 3,Moore RJ Osti OL Vernon-Roberts B | 1992 | Spine,1992，17，3： | 1 |
| 12 | Dextran cross-linked gelatin microspheres as a drug delivery-system显示文摘 | Rita Cortesi Elisabetta Esposito Maria Osti Giacomo Squarzoni Enea Menegatti Stanley Spencer Davis Claudio Nastruzzi | 1999 | Eur J Pharm Biopharm1999，47，： | 1 |
| 13 | Ultrasound of thyroid, para thyroid glands and neck lymph nodes 显示文摘 | Solbiati L Osti V Cova L | 2001 | Eur R adiol2001，11，： | 1 |
| 14 | Exclusive electron intra operative radiotherapy in early-stage breast cancer: amonoinsti tutional experience显示文摘 | MATTIA F OSTI A CARNEVALE S | 2013 | Anti Res2013，33，3： | 1 |
| 15 | Ostcoarthrosis of the facet joints resulting from anular rim lesions in sheep lumbar discs显示文摘 | Crotti TN Osti OL | 1999 | Spine1999，24，6： | 1 |
| 16 | Neoadjuvant chomoradiation for locally advanced carcinoma of the rectum显示文摘 | Osti MF Valedani M Masoni L | 2004 | Tumori2004，90，3： | 1 |
| 17 | MRI and discography of annular tears and intervertebral disc degeneration 显示文摘 | Fraser RD | 1992 | J Bone Joint Surg [Br]1992，74，： | 1 |
| 18 | Vibration welding of nylon 6 to nylon 66显示文摘 | Bates P J Dyck C Osti M | 2004 | Polymer Engineering and Science2004，44，4： | 1 |
| 19 | Annular tears and disc degene ration in the lumbar spine显示文摘 | 6,Osti OL Vernon-Roberts B Moore R | 1992 | J Bone Joint Surg,1992，74，： | 1 |
| 20 | Anulus tears and interverte- bral disc degeneration 显示文摘 | Osti OL Roberts BV Frepath P | 1990 | Spine1990，15，8： | 1 |
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