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| 1 | Laparoscopic hemicolectomy in a patient with situs inversustotalis显示文摘As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirror-image anatomy permitted safe operation using techniques not otherwise differing from those in ordinary cases. Thus, curative laparoscopic surgery for colon cancer in the presence of situs inversus is feasible and safe. | Yushi Fujiwara Yosuke Fukunaga Masayuki Higashino Shinya Tanimura Masashi Takemura Yoshinori Tanaka Harushi Osugi | 2007 | World Journal of Gastroenterology2007，13，37： | 6 |
| 2 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 3 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 4 | Utility of endoscopic ultrasonography in assessing the indications for endoscopic surgery of submucosal esophageal tumors 显示文摘 | Takada N Higashino M Osugi H | 1999 | Surg Endosc1999，13，3： | 2 |
| 5 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 6 | Pre-Injury magnesium treatment prevents traumatic brain injury- induced hippocampal ERK activation, neuronal loss, and cognitive dysfunction in the radial-arm maze test 显示文摘 | Enomoto T Osugi T Satoh H | 2005 | J Neurotrauma2005，22，7： | 1 |
| 7 | Quantitaative de-termination of duodenogastric reflux, prevalence of Helicobacter-phlori infection and concentrations of interleukin-8 显示文摘 | FUKUHARA K OSUGI H TAKADA N | 2003 | World JSurg2003，27，5： | 1 |
| 8 | Laparoscopic gastrectomy for gastric cancer: experience with more than 600 cases显示文摘 | S. Tanimura M. Higashino Y. Fukunaga M. Takemura Y. Tanaka Y. Fujiwara H. Osugi | 2008 | Surgical Endoscopy2008，，5： | 1 |
| 9 | Reconstructive procedure after distal gastrectomy for gastric cancer that best prevents duodenogastroesophageal reflux显示文摘 | Fukuhara K Osugi H Takada N | 2002 | World J Surg2002，26，12： | 1 |
| 10 | Low-dose paclitaxel therapy as second-line chemotherapy for patients who previously received TS-1 therapy 显示文摘 | Takemura M Osugi H Lee S | 2004 | Gan To Kagaku Ryoho2004，31，13： | 1 |
| 11 | Cardiacospecific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart 显示文摘 | Osugi T Oshima Y Fujio Y | 2002 | J Biol Chem2002，277，8： | 1 |
| 12 | Antithymocyte globulin and cyclosporine for treatment of 44 children with hepatitis associated aplastic anemia 显示文摘 | Osugi Y Yagasaki H Sako M Kosaka Y Taga T Ito T | 2007 | Haematologica2007，92，12： | 1 |
| 13 | Oral fluoropyrimidine anticaneer drug TS-1 for gastric cancer patients with peritoneal dissemination 显示文摘 | Osugi H Takemura M | 2002 | Oneol Bep2002，9，4： | 1 |
| 14 | Evaluation of color removal and degradation of a reactive textile azo dye on nanoporous TiO2 thin-film electrodes显示文摘 | CARNEIRO P A MARLY E OSUGI M E | 2004 | Electrochimica Acta2004，49，： | 1 |
| 15 | Thoracoscopic esophagectomy for intrathoracic esophageal cancer显示文摘 | Osugi H Takemura M Lee S | 2005 | Ann Thorac Cardicrvasc Surg2005，11，4： | 1 |
| 16 | Reconstructive procedure after distal gastrectomy for gastric cancer that best prevents duodenogastroesophageal reflux 显示文摘 | Fukuhara K Osugi H Takada N | 2002 | World J Surg2002，26，12： | 1 |
| 17 | Endogenous Wnt/beta - catenin signaling is required for cardiac differentiation in human embryonic stem cells显示文摘 | Paige SL Osugi T Afanasiev OK el al | 2010 | Plos One2010，5，11： | 1 |
| 18 | Study on critical dimension of printable phase defects using an EUV microscope显示文摘 | Kinoshita H Yoshizumi T Osugi M | 2009 | Microelec- iron Eng2009，86，： | 1 |
| 19 | Treatment with Candesartan Ombined with Angiotensin-converting Enzyme Inhibitor for Immunosuppressive Treatment-resistant Nephrotic Syndrome after Allogeneic Stem Cell Transplantation显示文摘 | OSUGI Y YAMADA H HOSOI G | 2006 | Int J Hematol2006，83，5： | 1 |
| 20 | Reconstructive procedure after distal gastrectomy to prevent remnant gastritis显示文摘 | Osugi H Fukuhara K Takada N | 2004 | Hepatogastroenterology2004，51，58： | 1 |
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