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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Influence of inheritance and pedogenesis on heavy metal distribution in soils of Sicily,Italy显示文摘 | Palumbo B Angelone M Bellanca A | 2000 | Geoderma2000，95，： | 1 |
| 3 | Measuring trade show effectiveness: An effective exercise? 显示文摘 | Herbig P Hara B O Palumbo F | 1994 | Industrial Marketing Management1994，23，2： | 1 |
| 4 | Influence of inheritance and pedogenesis on heavy metal distribution in soils of Sicily, Italy显示文摘 | Palumbo B Angelone M Bellanca A | 2000 | Geoderma2000，95，： | 1 |
| 5 | High temperature solar thermal processing of Zn(s) and CO from ZnO(s) and C(gr) using Ti2O3 and TiO2显示文摘 | Palumbo R D Campbell M B Grafe T | 1992 | Energy Int J1992，17，3： | 1 |
| 6 | A statewide analysisof RNs, intention to leave their position显示文摘 | Rambur B Palumbo MV McIntosh B | 2003 | Nurs Outlook2003，51，4： | 1 |
| 7 | Influence of inheritance and pedogenesis on heavy metals in soils of Sicily, italy 显示文摘 | PALUMBO B ANGELONE M BELLANCA A | 2000 | Geoderma2000，95，： | 1 |
| 8 | Progressive la- cunar stroke: Review of mechanisms, prognostic fea- tures, and putative treatments 显示文摘 | Del B A Palumbo V I_mnassa M | 2012 | Int J Stroke2012，7，4： | 1 |
| 9 | Differences between international and domestic trade show exhibitors 显示文摘 | Palumbo F O'Hara B Herbig P | 1998 | Academy of Marketing Studies Journal1998，2，2： | 1 |
| 10 | Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial 显示文摘 | Palumbo A B ringhen S Caravita T et a l | 2006 | Lancet2006，367，9513： | 1 |
| 11 | Psychological aspects oforthognathic treatment显示文摘 | Palumbo B Cassese R Fusetti S | 2006 | Minerva Stomatol2006，55，12： | 1 |
| 12 | Cells migra- ting to sites of tissue damage in response to the danger signal HMGBI require NF- kappaB activation显示文摘 | PALUMBO R GALVEZ B G PUSTERLA T | 2007 | J Cell Biol2007，179，1： | 1 |
| 13 | Association be- tween brain natriuretic peptide and extracellular water in hemo- dialysis patients 显示文摘 | Fagugll RM Palumbo B Rieeardi D | 2003 | Nephron Clin Pract2003，95，2： | 1 |
| 14 | Influence of inheritance and pedogenesis on heavy metal distribution in soils of Sicily,Italy显示文摘 | Palumbo B Angelone M Bellanca A | 2000 | Geoderma2000，95，： | 1 |
| 15 | Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments 显示文摘 | Del B Palumbo V Lamassa M | 2012 | Int J Stroke2012，7，4： | 1 |
| 16 | Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer's dis- ease ? 显示文摘 | Palumbo B Siepi D Sabalich I | 2008 | Funct Neurol2008，23，2： | 1 |
| 17 | Antigen identification starting from the genome: a 'Reverse Vaccinology' approach ap- plied to MenB显示文摘 | Palumbo E Fiaschi L Brunelli B etal | 2012 | Methods Mol Biol2012，799，： | 1 |
| 18 | ' The development ofdirect-to-consumer prescription drug advertising regulation 显示文摘 | FRANCIS B PALUMBO C MULLINS D | 2002 | Food Drug Cosmet Law J2002，57，3： | 1 |
| 19 | Differences in trade show behavior between north American-focused firms and worldwide-oriented firms显示文摘 | Herbig P Palumbo F O' Hara B(1996) | 1996 | International Journal of Commerce and Management1996，，： | 1 |
| 20 | Differences in trade show be- havior between manufacturers and service-oriented firms显示文摘 | Herbig P Palumbo F (YHara B | 1996 | Journal of Professional Service Marketing1996，14，2： | 1 |
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