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| 1 | COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘 | Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen | 2014 | Journal of Molecular Cell Biology2014，8，6： | 15 |
| 2 | Enhanced debromination of 4-bromophenol by the UV/sulfite process:Efficiency and mechanism显示文摘Halogenated aromatic compounds have attracted increasing concerns due to their toxicity and persistency in the environment, and dehalogenation is one of the promising treatment and detoxification methods. Herein, we systematically studied the debromination efficiency and mechanism of para-bromophenol(4-BP) by a recently developed UV/sulfite process. 4-BP underwent rapid degradation with the kinetics accelerated with the increasing sulfite concentration, pH(6.1–10) and temperature, whereas inhibited by dissolved oxygen and organic solvents. The apparent activation energy was estimated to be 27.8 kJ/mol. The degradation mechanism and pathways of 4-BP were explored by employing N_2O and nitrate as the electron scavengers and liquid chromatography/mass spectrometry to identify the intermediates. 4-BP degradation proceeded via at least two pathways including direct photolysis and hydrated electron-induced debromination. The contributions of both pathways were distinguished by quantifying the quantum yields of 4-BP via direct photolysis and hydrated electron production in the system. 4-BP could be readily completely debrominated with all the substituted Br released as Br-, and the degradation pathways were also proposed. This study would shed new light on the efficient dehalogenation of brominated aromatics by using the UV/sulfite process. | Bihuang Xie Xuchun Li Xianfeng Huang Zhe Xu Weiming Zhang Bingcai Pan | 2017 | Journal of Environmental Sciences2017，29，4： | 12 |
| 3 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 4 | Preparation of polymer-supported hydrated ferric oxide based on Donnan membrane effect and its application for arsenic removal显示文摘In the present study a novel technique was proposed to prepare a polymer-supported hydrated ferric oxide (D201-HFO) based on Donnan membrane effect by using a strongly basic anion exchanger D201 as the host material and FeCl3-HCl-NaCl solution as the reaction environment. D201-HFO was found to exhibit higher capacity for arsenic removal than a commercial sorbent Purolite ArsenX. Furthermore, it presents favorable adsorption selectivity for arsenic removal from aqueous solution, as well as satis- factory kinetics. Fixed-bed column experiments showed that arsenic sorption on D201-HFO could re- sult in concentration of this toxic metalloid element below 10 μg/L, which was the new maximum con- centration limit set recently by the European Commission and imposed by the US EPA and China. Also, the spent D201-HFO is amenable to efficient regeneration by NaOH-NaCl solution. | ZHANG QingJian PAN BingCai CHEN XinQing ZHANG WeiMing PAN BingJun ZHANG QuanXing L.LV X.S.ZHAO | 2008 | Science China Chemistry2008，51，4： | 4 |
| 5 | Amperometric detection of gold by differential pulse voltammetry using a DNA biosensor显示文摘A DNA biosensor with [Ru(DA-bpy)3]Cl2(DA-bpy:4,4'-diamino-2,2'-bipyridine) (RuL) as the electrochemical probe was prepared on pyrolytic graphite electrode (PGE) through the supramolecular interaction between RuL complex and DNA template. Cyclic voltammetry of RuL-DNA film showed a pair of stable and reversible peaks corresponding to the Ru(III)/Ru(II) redox potential of -0.165 V versus Ag|AgCl in pH 7.4 0.1 mol·L-1 Tris-HCl. The electron transfer was expected across the double-strand DNA by an 'electron tunneling' mechanism. When the DNA biosensor was immerged in gold (III) buffer solution, the current peak signal (I) of the RuL-DNA supramolecular depressed and △I was linear in the concentration range of Au ion from 1 × 10-7 to 2 × 10-5 mol·L-1 with a regression coefficient of 0.9879. The detection limit was 5 × 10-8 mol·L-1. The developed procedures were applied to the analysis of synthetic samples of real materials with good sensitivity and selectivity. | GAN Ning WANG Zhiying XU Weiming PAN Jianguo | 2007 | Rare Metals2007，26，2： | 2 |
| 6 | Heavy metal removal from water/wastewater by nanosized metal oxides: A review显示文摘 | Ming Hua Shujuan Zhang Bingcai Pan Weiming Zhang Lu Lv Quanxing Zhang | 2011 | Journal of Hazardous Materials2011，，： | 2 |
| 7 | Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo显示文摘Major histocompatibility complex(MHC)class I chain-related protein A(MICA),which is a ligand for human NKG2D,is expressed by a variety of epithelial tumor cells and promotes the activation of natural killer(NK),CD81 and cd-T cells.Although ectopic expression of MICA on tumor cells elicits anti-tumor responses,soluble MICA downregulates the activities of lymphocytes.In this study,we showed that recombinant,immobilized MICA(iMICA)molecules coated on plastic wells weakly promote peripheral NK cell activation,secretion of interferon(IFN)-c and degranulation without inducing apoptosis.In addition,iMICA synergized with IL-15 and soluble 4-1BB ligand(s4-1BBL)to expand NK cells 25-to 42-fold in a 13-day culture,whereas NK cells stimulated only with IL-15 and s4-1BBL expanded 10-to 16-fold.In contrast toNKcells expanded by IL-15 and s4-1BBL stimulation,NKcells expanded long term in the presence of iMICA exhibited increased cytotoxicity against leukemia cells.These results suggest that large numbers ofNKcells with high cytotoxicity can be generated by stimulation with IL-15 and s4-1BBL in the presence of iMICA and that these cells can be used for adoptive cancer immunotherapy. | Weijuan Gong Weiming Xiao Li Qian Chunxiang Gong Maozhi Hu Xianyuan Pan Mingchun Ji | 2010 | Cellular & Molecular Immunology2010，7，6： | 2 |
| 8 | Recyclable polymer-based nano-hydrous manganese dioxide for highly efficient Tl(I) removal from water显示文摘Tl(I)in water even at a trace level is fatal to human beings and the ecosystem.Here we fabricated a new polymer-supported nanocomposite(HMO-001)for efficient Tl(I)removal by encapsulating nanosized hydrous manganese dioxide(HMO)within a polystyrene cation exchanger(D-001).The resultant HMO-001 exhibited more preferable removal of Tl(I)than D-001 and IRC-748,an iminodiacetic chelating polymer,particularly in the presence of competing Ca(II)ions at greater levels in solution.Such preference was ascribed to the Donnan membrane effect caused by D-001 as well as the specific interaction between Tl(I)and HMO.The adsorbed Tl(I)was partially oxidized into insoluble Tl(III)by HMO at acidic pH,while negligible oxidation was observed at circumneutral pH.The exhausted HMO-001 was amenable to efficient regeneration by binary NaOH-NaClO solution for at least 10-cycle batch runs without any significant capacity loss.Fixed-bed column test of Tl(I)-contained industrial effluent and natural water further validated that Tl(I)retention on HMO-001 resulted in a conspicuous concentration drop from 1.3 mg/L to a value lower than 0.14 mg/L(maximum concentration level for industrial effluent regulated by US EPA)and from 1–4?g/L to a value lower than 0.1?g/L(drinking water standard regulated by China Health Ministry),respectively. | PAN BingCai WAN ShunLi ZHANG ShuJuan GUO QingWei XU ZhengCheng LV Lu ZHANG WeiMing | 2014 | Science China Chemistry2014，57，5： | 2 |
| 9 | Precise methods for conducted EMI modeling,analysis,and prediction显示文摘Focusing on the state-of-the-art conducted EMI prediction, this paper presents a noise source lumped circuit modeling and identification method, an EMI modeling method based on multiple slope approximation of switching transitions, and dou-ble Fourier integral method modeling PWM conversion units to achieve an accurate modeling of EMI noise source. Meanwhile, a new sensitivity analysis method, a general coupling model for steel ground loops, and a partial element equivalent circuit method are proposed to identify and characterize conducted EMI coupling paths. The EMI noise and propagation modeling provide an accurate prediction of conducted EMI in the entire frequency range (0―10 MHz) with good practicability and generality. Finally a new measurement approach is presented to identify the surface current of large dimensional metal shell. The proposed analytical modeling methodology is verified by experimental results. | MA WeiMing ZHAO ZhiHua MENG Jin PAN QiJun ZHANG Lei | 2008 | Science China(Technological Sciences)2008，51，6： | 2 |
| 10 | A new critical formula and mathematical model of double-tap interphase reactor in a six- phase tap-changer diode rectifier 显示文摘 | PAN Qijun MA Weiming LIU Dezhi | 2007 | IEEE Transactions on In- dustrial Electronics2007，54，1： | 1 |
| 11 | Adsorption equilibrium and heat of phenol onto aminated polymeric resins from aqueous solution 显示文摘 | Zhang Weiming Du Qiong Pan Bingcai | 2009 | Colloids Surf A : Physicochem Eng Aspects2009，346，： | 1 |
| 12 | Acid and organic resistant nano-hydrated zirconium oxide (HZO)/polystyrene hybrid adsorbent for arsenic removal from water显示文摘 | Zhigang Li Yanyang Zhang Jingsheng Xu Bingcai Pan Liang Chen Haojie Dong Weiming Zhang | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 13 | Sorption enhancement of 1-naphthol onto a hydrophilic hyper-cross-linked polymer resin显示文摘 | Weiming Zhang Changhong Hong Bingcai Pan Qingjian Zhang Peijuan Jiang Kun Jia | 2008 | Journal of Hazardous Materials2008，，1： | 1 |
| 14 | Application of the Polanyi potential theory to phthalates adsorption from aqueous solution with hyper-cross-linked polymer resins显示文摘 | Xu Zhengwen Zhang Weiming Pan Bingcai | | 0，，02： | 1 |
| 15 | Assessment on the removal of dimethyl phthalate from aqueous phase using a hydrophilic hyper-cross-linked polymer resin NDA-702 显示文摘 | Weiming Zhang Bingcai Pan Lu Lv | 2007 | Journal of Colloid and Interface Science2007，311，2： | 1 |
| 16 | Hydrogen embrittlement of Pt3Zr compound from first-principles 显示文摘 | Yong Pan Weiming Guan Ming Wen | 2014 | Journal of Alloys and Compounds2014，，585： | 1 |
| 17 | A new critical for- mula and mathematical model of double-tap interphase reactor in a six-phase tap-changer diode rectifier 显示文摘 | PAN Qijun MA Weiming LIU Dezhi | 2007 | IEEE Transactions on Industrial Electronics2007，54，1： | 1 |
| 18 | Adsorption equilibrium and heat of phenol onto aminated polymeric rosins from aqueous solution显示文摘 | Zhang Weiming Du Qiong Pan Bingcai | 2009 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2009，346，13： | 1 |
| 19 | Adsorption equilibrium and heat of phenol onto aminated polymeric resins from aqueous solution显示文摘 | Weiming Zhang Qiong Du Bingcai Pan | 2009 | Colloids and Surfaces A:Physicochem Eng Aspects2009，346，： | 1 |
| 20 | Highly efficient removal of heavy metals by polymer-supported nanosized hydrated Fe(III) oxides: Behavior and XPS study显示文摘 | Bingjun Pan Hui Qiu Bingcai Pan Guangze Nie Lili Xiao Lu Lv Weiming Zhang Quanxing Zhang Shourong Zheng | 2009 | Water Research2009，，3： | 1 |
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